Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Avacyn, Angel of Hope

Flying, vigilance, indestructible
Other permanents you control have indestructible.

Hundred-Handed One

Vigilance
{3}{W}{W}{W}: Monstrosity 3. (If this creature isn't monstrous, put three +1/+1 counters on it and it becomes monstrous.)
As long as Hundred-Handed One is monstrous, it has reach and can block an additional ninety-nine creatures each combat.

Avatar of Hope

If you have 3 or less life, this spell costs {6} less to cast.
Flying
Avatar of Hope can block any number of creatures.