This spell can't be countered.
Fry deals 5 damage to target creature or planeswalker that's white or blue.

Curse of Wizardry

As Curse of Wizardry enters the battlefield, choose a color.
Whenever a player casts a spell of the chosen color, that player loses 1 life.

Irini Sengir

Green enchantment spells and white enchantment spells cost {2} more to cast.

Aether Gust

Choose target spell or permanent that's red or green. Its owner puts it on the top or bottom of their library.

Dystopia

Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
At the beginning of each player's upkeep, that player sacrifices a green or white permanent.

Anarchy

Putrefaction

Whenever a player casts a green or white spell, that player discards a card.

Dark Betrayal

Perish

Destroy all green creatures. They can't be regenerated.

Thought Prison

Imprint — When Thought Prison enters the battlefield, you may have target player reveal their hand. If you do, choose a nonland card from it and exile that card.
Whenever a player casts a spell that shares a color or mana value with the exiled card, Thought Prison deals 2 damage to that player.

Nightcreep

Until end of turn, all creatures become black and all lands become Swamps.

Persecute

Choose a color. Target player reveals their hand and discards all cards of that color.

Rending Volley

This spell can't be countered.
Rending Volley deals 4 damage to target white or blue creature.

Circle of Affliction

As Circle of Affliction enters the battlefield, choose a color.
Whenever a source of the chosen color deals damage to you, you may pay {1}. If you do, target player loses 1 life and you gain 1 life.

Jace's Defeat

Counter target blue spell. If it was a Jace planeswalker spell, scry 2.

Deathmark

Red Elemental Blast

Choose one —
• Counter target blue spell.
• Destroy target blue permanent.

Blue Elemental Blast

Choose one —
• Counter target red spell.
• Destroy target red permanent.

Flashfreeze

Defiler of Souls

Flying
At the beginning of each player's upkeep, that player sacrifices a monocolored creature.

Hydroblast

Choose one —
• Counter target spell if it's red.
• Destroy target permanent if it's red.

Pyroblast

Choose one —
• Counter target spell if it's blue.
• Destroy target permanent if it's blue.

Dread of Night

Sudden Demise

Choose a color. Sudden Demise deals X damage to each creature of the chosen color.

Yawgmoth's Edict

Whenever an opponent casts a white spell, that player loses 1 life and you gain 1 life.

Heat Wave

Cumulative upkeep {R} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
Blue creatures can't block creatures you control.
Nonblue creatures can't block creatures you control unless their controller pays 1 life for each blocking creature they control.

Bereavement

Whenever a green creature dies, its controller discards a card.

Self-Inflicted Wound

Target opponent sacrifices a green or white creature. If that player does, they lose 2 life.

Gloom

White spells cost {3} more to cast.
Activated abilities of white enchantments cost {3} more to activate.

Noxious Grasp

Destroy target creature or planeswalker that's green or white. You gain 1 life.

Insight

Whenever an opponent casts a green spell, you draw a card.

Darkest Hour

Combust

This spell can't be countered.
Combust deals 5 damage to target white or blue creature. The damage can't be prevented.

Crosis, the Purger

Flying
Whenever Crosis, the Purger deals combat damage to a player, you may pay {2}{B}. If you do, choose a color, then that player reveals their hand and discards all cards of that color.