Have

Treasonous Ogre

Dethrone (Whenever this creature attacks the player with the most life or tied for most life, put a +1/+1 counter on it.)
Pay 3 life: Add {R}.

Dregs of Sorrow

Destroy X target nonblack creatures. Draw X cards.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Hit the Mother Lode

Discover 10. If the discovered card's mana value is less than 10, create a number of tapped Treasure tokens equal to the difference. (To discover 10, exile cards from the top of your library until you exile a nonland card with mana value 10 or less. Cast it without paying its mana cost or put it into your hand. Put the rest on the bottom in a random order.)

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Getting

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Curse of Fool's Wisdom

Enchant player
Whenever enchanted player draws a card, they lose 2 life and you gain 2 life.
Madness {3}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Damnable Pact

Target player draws X cards and loses X life.

Blood Crypt

({T}: Add {B} or {R}.)
As Blood Crypt enters, you may pay 2 life. If you don't, it enters tapped.

Hall of the Bandit Lord

Hall of the Bandit Lord enters tapped.
{T}, Pay 3 life: Add {C}. If that mana is spent on a creature spell, it gains haste.

Verdant Catacombs

{T}, Pay 1 life, Sacrifice Verdant Catacombs: Search your library for a Swamp or Forest card, put it onto the battlefield, then shuffle.

Barbarian Ring

{T}: Add {R}. Barbarian Ring deals 1 damage to you.
Threshold — {R}, {T}, Sacrifice Barbarian Ring: It deals 2 damage to any target. Activate only if seven or more cards are in your graveyard.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Thought Vessel

Lightning Bolt

Lightning Bolt deals 3 damage to any target.

Profane Command

Choose two —
• Target player loses X life.
• Return target creature card with mana value X or less from your graveyard to the battlefield.
• Target creature gets -X/-X until end of turn.
• Up to X target creatures gain fear until end of turn. (They can't be blocked except by artifact creatures and/or black creatures.)

Cabal Pit

{T}: Add {B}. Cabal Pit deals 1 damage to you.
Threshold — {B}, {T}, Sacrifice Cabal Pit: Target creature gets -2/-2 until end of turn. Activate only if seven or more cards are in your graveyard.

Wheel of Misfortune

Each player secretly chooses a number 0 or greater, then all players reveal those numbers simultaneously and determine the highest and lowest numbers revealed this way. Wheel of Misfortune deals damage equal to the highest number to each player who chose that number. Each player who didn't choose the lowest number discards their hand, then draws seven cards.

Ifnir Deadlands

{T}: Add {C}.
{T}, Pay 1 life: Add {B}.
{2}{B}{B}, {T}, Sacrifice a Desert: Put two -1/-1 counters on target creature an opponent controls. Activate only as a sorcery.

Erebos's Intervention

Choose one —
• Target creature gets -X/-X until end of turn. You gain X life.
• Exile up to twice X target cards from graveyards.

Night's Whisper

Mount Doom

{T}, Pay 1 life: Add {B} or {R}.
{1}{B}{R}, {T}: Mount Doom deals 1 damage to each opponent.
{5}{B}{R}, {T}, Sacrifice Mount Doom and a legendary artifact: Choose up to two creatures, then destroy the rest. Activate only as a sorcery.

Swamp

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap Staff of Compleation.

Sol Ring

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Grapeshot

Grapeshot deals 1 damage to any target.
Storm (When you cast this spell, copy it for each spell cast before it this turn. You may choose new targets for the copies.)

Battle at the Bridge

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
Target creature gets -X/-X until end of turn. You gain X life.

Infernal Grasp

Destroy target creature. You lose 2 life.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Tinybones, Bauble Burglar

Whenever an opponent discards a card, exile it from their graveyard with a stash counter on it.
During your turn, you may play cards you don't own with stash counters on them from exile, and mana of any type can be spent to cast those spells.
{3}{B}, {T}: Each opponent discards a card. Activate only as a sorcery.

Diabolic Revelation

Search your library for up to X cards, put those cards into your hand, then shuffle.

Have Somewhere But Can’t Find

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Boseiju, Who Shelters All

Boseiju, Who Shelters All enters tapped.
{T}, Pay 2 life: Add {C}. If that mana is spent on an instant or sorcery spell, that spell can't be countered.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Street Wraith

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
Cycling—Pay 2 life. (Pay 2 life, Discard this card: Draw a card.)

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Greed

Apex of Power

Exile the top seven cards of your library. Until end of turn, you may cast spells from among them.
If this spell was cast from your hand, add ten mana of any one color.

Mana Confluence

{T}, Pay 1 life: Add one mana of any color.

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Blood Pact

Target player draws two cards and loses 2 life.

Asmodeus the Archfiend

Binding Contract — If you would draw a card, exile the top card of your library face down instead.
{B}{B}{B}: Draw seven cards.
{B}: Return all cards exiled with Asmodeus the Archfiend to their owner's hand and you lose that much life.

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Treasure

{T}, Sacrifice this artifact: Add one mana of any color.

Talisman of Indulgence

{T}: Add {C}.
{T}: Add {B} or {R}. Talisman of Indulgence deals 1 damage to you.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

March of Wretched Sorrow

As an additional cost to cast this spell, you may exile any number of black cards from your hand. This spell costs {2} less to cast for each card exiled this way.
March of Wretched Sorrow deals X damage to target creature or planeswalker and you gain X life.

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Dark Tutelage

Greven, Predator Captain

Menace
Greven, Predator Captain gets +X/+0, where X is the amount of life you've lost this turn.
Whenever Greven attacks, you may sacrifice another creature. If you do, you draw cards equal to that creature's power and you lose life equal to that creature's toughness.

Electrodominance

Electrodominance deals X damage to any target. You may cast a spell with mana value X or less from your hand without paying its mana cost.

Fire Covenant

As an additional cost to cast this spell, pay X life.
Fire Covenant deals X damage divided as you choose among any number of target creatures.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Crackle with Power

Crackle with Power deals five times X damage to each of up to X targets.

Sign in Blood

Rowan, Scion of War

Menace
{T}: Spells you cast this turn that are black and/or red cost {X} less to cast, where X is the amount of life you lost this turn. Activate only as a sorcery.

Ribbons

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Each opponent loses X life.

Cut // Ribbons

Hell to Pay

Hell to Pay deals X damage to target creature. Create a number of tapped Treasure tokens equal to the amount of excess damage dealt to that creature this way.

City of Brass

Whenever City of Brass becomes tapped, it deals 1 damage to you.
{T}: Add one mana of any color.

Mountain

Shapeshifter

Changeling (This token is every creature type.)

Tavern Swindler

{T}, Pay 3 life: Flip a coin. If you win the flip, you gain 6 life.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Temple of Malice

This land enters tapped.
When this land enters, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{T}: Add {B} or {R}.

Comet Storm

Multikicker {1} (You may pay an additional {1} any number of times as you cast this spell.)
Choose any target, then choose another target for each time this spell was kicked. Comet Storm deals X damage to each of them.

Storm King's Thunder

When you next cast an instant or sorcery spell this turn, copy that spell X times. You may choose new targets for the copies.

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Suffer the Past

Exile X target cards from target player's graveyard. For each card exiled this way, that player loses 1 life and you gain 1 life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Snuff Out

If you control a Swamp, you may pay 4 life rather than pay this spell's mana cost.
Destroy target nonblack creature. It can't be regenerated.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Jeska's Will

Choose one. If you control a commander as you cast this spell, you may choose both instead.
• Add {R} for each card in target opponent's hand.
• Exile the top three cards of your library. You may play them this turn.

Soul Channeling

Enchant creature
Pay 2 life: Regenerate enchanted creature.

Sulfurous Springs

{T}: Add {C}.
{T}: Add {B} or {R}. Sulfurous Springs deals 1 damage to you.

Bloodstained Mire

{T}, Pay 1 life, Sacrifice Bloodstained Mire: Search your library for a Swamp or Mountain card, put it onto the battlefield, then shuffle.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Drakuseth, Maw of Flames

Flying
Whenever Drakuseth attacks, it deals 4 damage to any target and 3 damage to each of up to two other targets.

Mana Vault

Mana Vault doesn't untap during your untap step.
At the beginning of your upkeep, you may pay {4}. If you do, untap Mana Vault.
At the beginning of your draw step, if Mana Vault is tapped, it deals 1 damage to you.
{T}: Add {C}{C}{C}.

Stormfist Crusader

Menace
At the beginning of your upkeep, each player draws a card and loses 1 life.

Rakdos Charm

Choose one —
• Exile target player's graveyard.
• Destroy target artifact.
• Each creature deals 1 damage to its controller.

Myr Convert

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
{T}, Pay 2 life: Add one mana of any color.