Niv-Mizzet, Guildpact

Flying, hexproof from multicolored
Whenever Niv-Mizzet, Guildpact deals combat damage to a player, it deals X damage to any target, target player draws X cards, and you gain X life, where X is the number of different color pairs among permanents you control that are exactly two colors.

Sultai Charm

Choose one —
• Destroy target monocolored creature.
• Destroy target artifact or enchantment.
• Draw two cards, then discard a card.

Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Abrupt Decay

This spell can't be countered.
Destroy target nonland permanent with mana value 3 or less.

Faeburrow Elder

Vigilance
Faeburrow Elder gets +1/+1 for each color among permanents you control.
{T}: For each color among permanents you control, add one mana of that color.

General Ferrous Rokiric

Hexproof from monocolored
Whenever you cast a multicolored spell, create a 4/4 red and white Golem artifact creature token.

Culling Ritual

Destroy each nonland permanent with mana value 2 or less. Add {B} or {G} for each permanent destroyed this way.

Deathrite Shaman

{T}: Exile target land card from a graveyard. Add one mana of any color.
{B}, {T}: Exile target instant or sorcery card from a graveyard. Each opponent loses 2 life.
{G}, {T}: Exile target creature card from a graveyard. You gain 2 life.

O-Kagachi Made Manifest

O-Kagachi Made Manifest is all colors.
Flying, trample
Whenever O-Kagachi Made Manifest attacks, defending player chooses a nonland card in your graveyard. Return that card to your hand. O-Kagachi Made Manifest gets +X/+0 until end of turn, where X is the mana value of that card.

The Kami War

(As this Saga enters and after your draw step, add a lore counter.)
I — Exile target nonland permanent an opponent controls.
II — Return up to one other target nonland permanent to its owner's hand. Then each opponent discards a card.
III — Exile this Saga, then return it to the battlefield transformed under your control.

The Kami War // O-Kagachi Made Manifest

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Putrefy

Destroy target artifact or creature. It can't be regenerated.

Naya Hushblade

As long as you control another multicolored permanent, Naya Hushblade gets +1/+1 and has shroud. (It can't be the target of spells or abilities.)

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Jund Hackblade

As long as you control another multicolored permanent, Jund Hackblade gets +1/+1 and has haste.

Obscura Charm

Choose one —
• Return target multicolored permanent card with mana value 3 or less from your graveyard to the battlefield tapped.
• Counter target instant or sorcery spell.
• Destroy target creature or planeswalker with mana value 3 or less.

Notion Thief

Flash
If an opponent would draw a card except the first one they draw in each of their draw steps, instead that player skips that draw and you draw a card.

Void Rend

This spell can't be countered.
Destroy target nonland permanent.

Pillar of the Paruns

{T}: Add one mana of any color. Spend this mana only to cast a multicolored spell.

Knight of New Alara

Each other multicolored creature you control gets +1/+1 for each of its colors.

Glass of the Guildpact

Multicolored creatures you control get +1/+1.

Grixis Grimblade

As long as you control another multicolored permanent, Grixis Grimblade gets +1/+1 and has deathtouch. (Any amount of damage it deals to a creature is enough to destroy that creature.)

Crackling Doom

Crackling Doom deals 2 damage to each opponent. Each opponent sacrifices a creature with the greatest power among creatures that player controls.

Eerie Ultimatum

Return any number of permanent cards with different names from your graveyard to the battlefield.

Esper Stormblade

As long as you control another multicolored permanent, Esper Stormblade gets +1/+1 and has flying.

Bedevil

Destroy target artifact, creature, or planeswalker.

Maelstrom Nexus

The first spell you cast each turn has cascade. (When you cast your first spell, exile cards from the top of your library until you exile a nonland card that costs less. You may cast it without paying its mana cost. Put the exiled cards on the bottom in a random order.)

Niv-Mizzet, Parun

This spell can't be countered.
Flying
Whenever you draw a card, Niv-Mizzet, Parun deals 1 damage to any target.
Whenever a player casts an instant or sorcery spell, you draw a card.

Villainous Wealth

Target opponent exiles the top X cards of their library. You may cast any number of spells with mana value X or less from among them without paying their mana costs.

Hero of Precinct One

Whenever you cast a multicolored spell, create a 1/1 white Human creature token.

Goblin Electromancer

Instant and sorcery spells you cast cost {1} less to cast.

Lilah, Undefeated Slickshot

Prowess (Whenever you cast a noncreature spell, this creature gets +1/+1 until end of turn.)
Whenever you cast a multicolored instant or sorcery spell from your hand, exile that spell instead of putting it into your graveyard as it resolves. If you do, it becomes plotted. (You may cast it as a sorcery on a later turn without paying its mana cost.)