Toothy, Imaginary Friend

Partner with Pir, Imaginative Rascal (When this creature enters, target player may put Pir into their hand from their library, then shuffle.)
Whenever you draw a card, put a +1/+1 counter on Toothy, Imaginary Friend.
When Toothy leaves the battlefield, draw a card for each +1/+1 counter on it.

Simic Growth Chamber

Simic Growth Chamber enters tapped.
When Simic Growth Chamber enters, return a land you control to its owner's hand.
{T}: Add {G}{U}.

Misty Rainforest

{T}, Pay 1 life, Sacrifice Misty Rainforest: Search your library for a Forest or Island card, put it onto the battlefield, then shuffle.

Rishkar, Peema Renegade

When Rishkar, Peema Renegade enters, put a +1/+1 counter on each of up to two target creatures.
Each creature you control with a counter on it has "{T}: Add {G}."

Growth Spiral

Draw a card. You may put a land card from your hand onto the battlefield.

Forgotten Ancient

Whenever a player casts a spell, you may put a +1/+1 counter on Forgotten Ancient.
At the beginning of your upkeep, you may move any number of +1/+1 counters from Forgotten Ancient onto other creatures.

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Rapid Hybridization

Destroy target creature. It can't be regenerated. That creature's controller creates a 3/3 green Frog Lizard creature token.

Karn's Bastion

{T}: Add {C}.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Temple of Mystery

Temple of Mystery enters tapped.
When Temple of Mystery enters, scry 1.
{T}: Add {G} or {U}.

Mutational Advantage

Permanents you control with counters on them gain hexproof and indestructible until end of turn. Prevent all damage that would be dealt to those permanents this turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Flooded Grove

{T}: Add {C}.
{G/U}, {T}: Add {G}{G}, {G}{U}, or {U}{U}.

Managorger Hydra

Trample
Whenever a player casts a spell, put a +1/+1 counter on Managorger Hydra.

Simic Signet

Kami of Whispered Hopes

If one or more +1/+1 counters would be put on a permanent you control, that many plus one +1/+1 counters are put on that permanent instead.
{T}: Add X mana of any one color, where X is Kami of Whispered Hopes's power.

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Master Biomancer

Each other creature you control enters with a number of additional +1/+1 counters on it equal to Master Biomancer's power and as a Mutant in addition to its other types.

Chasm Skulker

Whenever you draw a card, put a +1/+1 counter on Chasm Skulker.
When Chasm Skulker dies, create X 1/1 blue Squid creature tokens with islandwalk, where X is the number of +1/+1 counters on Chasm Skulker. (They can't be blocked as long as defending player controls an Island.)

Beast Within

Destroy target permanent. Its controller creates a 3/3 green Beast creature token.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Eternal Witness

When Eternal Witness enters, you may return target card from your graveyard to your hand.

Wave Goodbye

Return each creature without a +1/+1 counter on it to its owner's hand.

Thought Vessel

Hedge Maze

({T}: Add {G} or {U}.)
Hedge Maze enters tapped.
When Hedge Maze enters, surveil 1. (Look at the top card of your library. You may put it into your graveyard.)

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Jace, Wielder of Mysteries

If you would draw a card while your library has no cards in it, you win the game instead.
+1: Target player mills two cards. Draw a card.
−8: Draw seven cards. Then if your library has no cards in it, you win the game.

Pir, Imaginative Rascal

Partner with Toothy, Imaginary Friend (When this creature enters, target player may put Toothy into their hand from their library, then shuffle.)
If one or more counters would be put on a permanent your team controls, that many plus one of each of those kinds of counters are put on that permanent instead.

Evolution Sage

Landfall — Whenever a land you control enters, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Displacer Kitten

Avoidance — Whenever you cast a noncreature spell, exile up to one target nonland permanent you control, then return that card to the battlefield under its owner's control.

Herald of Secret Streams

Creatures you control with +1/+1 counters on them can't be blocked.

Yavimaya Coast

{T}: Add {C}.
{T}: Add {G} or {U}. Yavimaya Coast deals 1 damage to you.

Ozolith, the Shattered Spire

If one or more +1/+1 counters would be put on an artifact or creature you control, that many plus one +1/+1 counters are put on it instead.
{1}{G}, {T}: Put a +1/+1 counter on target artifact or creature you control. Activate only as a sorcery.
Cycling {2} ({2}, Discard this card: Draw a card.)

Hardened Scales

If one or more +1/+1 counters would be put on a creature you control, that many plus one +1/+1 counters are put on it instead.

Dreamroot Cascade

Dreamroot Cascade enters tapped unless you control two or more other lands.
{T}: Add {G} or {U}.

Hinterland Harbor

Hinterland Harbor enters tapped unless you control a Forest or an Island.
{T}: Add {G} or {U}.

Cyclonic Rift

Return target nonland permanent you don't control to its owner's hand.
Overload {6}{U} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Heroic Intervention

Permanents you control gain hexproof and indestructible until end of turn.

Brainstorm

Draw three cards, then put two cards from your hand on top of your library in any order.

Kodama of the West Tree

Reach
Modified creatures you control have trample. (Equipment, Auras you control, and counters are modifications.)
Whenever a modified creature you control deals combat damage to a player, search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Counterspell

Planar Incision

Exile target artifact or creature, then return it to the battlefield under its owner's control with a +1/+1 counter on it.

Rampant Growth

Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Simic Ascendancy

{1}{G}{U}: Put a +1/+1 counter on target creature you control.
Whenever one or more +1/+1 counters are put on a creature you control, put that many growth counters on Simic Ascendancy.
At the beginning of your upkeep, if Simic Ascendancy has twenty or more growth counters on it, you win the game.