Slash the Ranks

Destroy all creatures and planeswalkers except for commanders.

Kirtar's Wrath

Destroy all creatures. They can't be regenerated.
Threshold — If seven or more cards are in your graveyard, instead destroy all creatures, then create two 1/1 white Spirit creature tokens with flying. Creatures destroyed this way can't be regenerated.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Day of Judgment

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Wrath of God

Destroy all creatures. They can't be regenerated.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Sephara, Sky's Blade

You may pay {W} and tap four untapped creatures you control with flying rather than pay this spell's mana cost.
Flying, lifelink
Other creatures you control with flying have indestructible. (Damage and effects that say "destroy" don't destroy them.)

Planar Cleansing

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.