Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Phyrexian Obliterator

Trample
Whenever a source deals damage to Phyrexian Obliterator, that source's controller sacrifices that many permanents of their choice.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Sensei's Divining Top

{1}: Look at the top three cards of your library, then put them back in any order.
{T}: Draw a card, then put Sensei's Divining Top on top of its owner's library.

Professor's Warning

Choose one —
• Put a +1/+1 counter on target creature.
• Target creature gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Pact of the Serpent

Choose a creature type. Target player draws X cards and loses X life, where X is the number of creatures they control of the chosen type.

Font of Mythos

At the beginning of each player's draw step, that player draws two additional cards.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Snow-Covered Swamp

Rise of the Dark Realms

Put all creature cards from all graveyards onto the battlefield under your control.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

War Room

{T}: Add {C}.
{3}, {T}, Pay life equal to the number of colors in your commanders' color identity: Draw a card.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Scheming Symmetry

Choose two target players. Each of them searches their library for a card, then shuffles and puts that card on top.

Geier Reach Sanitarium

{T}: Add {C}.
{2}, {T}: Each player draws a card, then discards a card.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Magus of the Coffers

{2}, {T}: Add {B} for each Swamp you control.

Undying Malice

Until end of turn, target creature gains "When this creature dies, return it to the battlefield tapped under its owner's control with a +1/+1 counter on it."

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Not Dead After All

Until end of turn, target creature you control gains "When this creature dies, return it to the battlefield tapped under its owner's control, then create a Wicked Role token attached to it." (Enchanted creature gets +1/+1. When this Aura is put into a graveyard, each opponent loses 1 life.)

Snuff Out

If you control a Swamp, you may pay 4 life rather than pay this spell's mana cost.
Destroy target nonblack creature. It can't be regenerated.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Ophiomancer

At the beginning of each upkeep, if you control no Snakes, create a 1/1 black Snake creature token with deathtouch.

Damnation

Destroy all creatures. They can't be regenerated.

Sol Ring

Bubbling Muck

Until end of turn, whenever a player taps a Swamp for mana, that player adds an additional {B}.

Library of Leng

You have no maximum hand size.
If an effect causes you to discard a card, discard it, but you may put it on top of your library instead of into your graveyard.

Jet Medallion

Black spells you cast cost {1} less to cast.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Blood on the Snow

Choose one —
• Destroy all creatures.
• Destroy all planeswalkers.
Then return a creature or planeswalker card with mana value X or less from your graveyard to the battlefield, where X is the amount of {S} spent to cast this spell. ({S} is mana from a snow source.)

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Mikokoro, Center of the Sea

{T}: Add {C}.
{2}, {T}: Each player draws a card.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Culling the Weak

As an additional cost to cast this spell, sacrifice a creature.
Add {B}{B}{B}{B}.

Indulgent Tormentor

Flying
At the beginning of your upkeep, draw a card unless target opponent sacrifices a creature of their choice or pays 3 life.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Cabal Coffers

Invoke Despair

Target opponent sacrifices a creature of their choice. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Professor Onyx

Magecraft — Whenever you cast or copy an instant or sorcery spell, each opponent loses 2 life and you gain 2 life.
+1: You lose 1 life. Look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
−3: Each opponent sacrifices a creature with the greatest power among creatures that player controls.
−8: Each opponent may discard a card. If they don't, they lose 3 life. Repeat this process six more times.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Eliminate

Destroy target creature or planeswalker with mana value 3 or less.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Otherworld Atlas

{T}: Put a charge counter on Otherworld Atlas.
{T}: Each player draws a card for each charge counter on Otherworld Atlas.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Cabal Ritual

Add {B}{B}{B}.
Threshold — Add {B}{B}{B}{B}{B} instead if seven or more cards are in your graveyard.

Night's Whisper

Howling Mine

At the beginning of each player's draw step, if Howling Mine is untapped, that player draws an additional card.

Dark Ritual

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Roaming Throne

Ward {2}
As Roaming Throne enters, choose a creature type.
Roaming Throne is the chosen type in addition to its other types.
If a triggered ability of another creature you control of the chosen type triggers, it triggers an additional time.

Mesmeric Orb

Whenever a permanent becomes untapped, that permanent's controller mills a card.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Chain of Smog

Target player discards two cards. That player may copy this spell and may choose a new target for that copy.

Commander's Plate

Equipped creature gets +3/+3 and has protection from each color that's not in your commander's color identity.
Equip commander {3}
Equip {5}

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Zenith Chronicler

Whenever a player casts their first multicolored spell each turn, each other player draws a card.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Go for the Throat

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.