Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Ulamog, the Ceaseless Hunger

When you cast this spell, exile two target permanents.
Indestructible
Whenever Ulamog, the Ceaseless Hunger attacks, defending player exiles the top twenty cards of their library.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Karlach, Fury of Avernus

Whenever you attack, if it's the first combat phase of the turn, untap all attacking creatures. They gain first strike until end of turn. After this phase, there is an additional combat phase.
Choose a Background (You can have a Background as a second commander.)

Animate Dead

Enchant creature card in a graveyard
When Animate Dead enters the battlefield, if it's on the battlefield, it loses "enchant creature card in a graveyard" and gains "enchant creature put onto the battlefield with Animate Dead." Return enchanted creature card to the battlefield under your control and attach Animate Dead to it. When Animate Dead leaves the battlefield, that creature's controller sacrifices it.
Enchanted creature gets -1/-0.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Luxury Suite

Luxury Suite enters the battlefield tapped unless you have two or more opponents.
{T}: Add {B} or {R}.

Night's Whisper

Millikin

{T}, Mill a card: Add {C}. (To mill a card, put the top card of your library into your graveyard.)

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Chainer, Nightmare Adept

Discard a card: You may cast a creature spell from your graveyard this turn. Activate only once each turn.
Whenever a nontoken creature enters the battlefield under your control, if you didn't cast it from your hand, it gains haste until your next turn.

Stinkweed Imp

Flying
Whenever Stinkweed Imp deals combat damage to a creature, destroy that creature.
Dredge 5 (If you would draw a card, you may mill five cards instead. If you do, return this card from your graveyard to your hand.)

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Another Chance

You may mill two cards. Then return up to two creature cards from your graveyard to your hand. (To mill two cards, put the top two cards of your library into your graveyard.)

Geothermal Bog

({T}: Add {B} or {R}.)
Geothermal Bog enters the battlefield tapped.

Charmbreaker Devils

At the beginning of your upkeep, return an instant or sorcery card at random from your graveyard to your hand.
Whenever you cast an instant or sorcery spell, Charmbreaker Devils gets +4/+0 until end of turn.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Blood Crypt

({T}: Add {B} or {R}.)
As Blood Crypt enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Reassembling Skeleton

{1}{B}: Return Reassembling Skeleton from your graveyard to the battlefield tapped.

Juri, Master of the Revue

Whenever you sacrifice a permanent, put a +1/+1 counter on Juri, Master of the Revue.
When Juri dies, it deals damage equal to its power to any target.

Mesmeric Orb

Whenever a permanent becomes untapped, that permanent's controller mills a card.

Bladewing, Deathless Tyrant

Flying, haste
Whenever Bladewing, Deathless Tyrant deals combat damage to a player or planeswalker, for each creature card in your graveyard, create a 2/2 black Zombie Knight creature token with menace.

Warstorm Surge

Whenever a creature enters the battlefield under your control, it deals damage equal to its power to any target.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Blackcleave Cliffs

Blackcleave Cliffs enters the battlefield tapped unless you control two or fewer other lands.
{T}: Add {B} or {R}.

Thriving Bluff

Thriving Bluff enters the battlefield tapped.
As Thriving Bluff enters the battlefield, choose a color other than red.
{T}: Add {R} or one mana of the chosen color.

Bedevil

Destroy target artifact, creature, or planeswalker.

Rakdos, Lord of Riots

You can't cast this spell unless an opponent lost life this turn.
Flying, trample
Creature spells you cast cost {1} less to cast for each 1 life your opponents have lost this turn.

Rakdos Signet

Chaos Warp

The owner of target permanent shuffles it into their library, then reveals the top card of their library. If it's a permanent card, they put it onto the battlefield.

Terminate

Destroy target creature. It can't be regenerated.

Altar of Dementia

Sacrifice a creature: Target player mills cards equal to the sacrificed creature's power.

Anger

Haste
As long as Anger is in your graveyard and you control a Mountain, creatures you control have haste.

Ancient Craving

You draw three cards and you lose 3 life.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Archpriest of Shadows

Backup 1 (When this creature enters the battlefield, put a +1/+1 counter on target creature. If that's another creature, it gains the following abilities until end of turn.)
Deathtouch
Whenever this creature deals combat damage to a player or battle, return target creature card from your graveyard to the battlefield.

Lord of the Void

Flying
Whenever Lord of the Void deals combat damage to a player, exile the top seven cards of that player's library, then put a creature card from among them onto the battlefield under your control.

The Core

(Transforms from Matzalantli.)
Fathomless descent — {T}: Add X mana of any one color, where X is the number of permanent cards in your graveyard.

Matzalantli, the Great Door

{T}: Draw a card, then discard a card.
{4}, {T}: Transform Matzalantli, the Great Door. Activate only if there are four or more permanent types among cards in your graveyard. (Artifact, battle, creature, enchantment, land, and planeswalker are permanent types.)

Matzalantli, the Great Door // The Core

Jeweled Lotus

{T}, Sacrifice Jeweled Lotus: Add three mana of any one color. Spend this mana only to cast your commander.

Final Parting

Search your library for two cards. Put one into your hand and the other into your graveyard. Then shuffle.

Mayhem Devil

Whenever a player sacrifices a permanent, Mayhem Devil deals 1 damage to any target.

Stalactite Stalker

Menace
At the beginning of your end step, if you descended this turn, put a +1/+1 counter on Stalactite Stalker. (You descended if a permanent card was put into your graveyard from anywhere.)
{2}{B}, Sacrifice Stalactite Stalker: Target creature gets -X/-X until end of turn, where X is Stalactite Stalker's power.

Black Sun's Zenith

Put X -1/-1 counters on each creature. Shuffle Black Sun's Zenith into its owner's library.

Nighthowler

Bestow {2}{B}{B} (If you cast this card for its bestow cost, it's an Aura spell with enchant creature. It becomes a creature again if it's not attached to a creature.)
Nighthowler and enchanted creature each get +X/+X, where X is the number of creature cards in all graveyards.

Incarnation Technique

Demonstrate (When you cast this spell, you may copy it. If you do, choose an opponent to also copy it.)
Mill five cards, then return a creature card from your graveyard to the battlefield.

Dragonskull Summit

Dragonskull Summit enters the battlefield tapped unless you control a Swamp or a Mountain.
{T}: Add {B} or {R}.

Mountain

Bitter Triumph

As an additional cost to cast this spell, discard a card or pay 3 life.
Destroy target creature or planeswalker.

Ruthless Invasion

({R/P} can be paid with either {R} or 2 life.)
Nonartifact creatures can't block this turn.

Demand Answers

As an additional cost to cast this spell, sacrifice an artifact or discard a card.
Draw two cards.

Angel of Suffering

Flying
If damage would be dealt to you, prevent that damage and mill twice that many cards.

Rakdos Charm

Choose one —
• Exile target player's graveyard.
• Destroy target artifact.
• Each creature deals 1 damage to its controller.

Bloodfell Caves

Bloodfell Caves enters the battlefield tapped.
When Bloodfell Caves enters the battlefield, you gain 1 life.
{T}: Add {B} or {R}.

Read the Bones

Scry 2, then draw two cards. You lose 2 life.

Blood for the Blood God!

This spell costs {1} less to cast for each creature that died this turn.
Discard your hand, then draw eight cards. Blood for the Blood God! deals 8 damage to each opponent. Exile Blood for the Blood God!

Sewer Nemesis

As Sewer Nemesis enters the battlefield, choose a player.
Sewer Nemesis's power and toughness are each equal to the number of cards in the chosen player's graveyard.
Whenever the chosen player casts a spell, that player mills a card.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Raphael, Fiendish Savior

Flying
Other Demons, Devils, Imps, and Tieflings you control get +1/+1 and have lifelink.
At the beginning of each end step, if a creature card was put into your graveyard from anywhere this turn, create a 1/1 red Devil creature token with "When this creature dies, it deals 1 damage to any target."

Everflowing Chalice

Multikicker {2} (You may pay an additional {2} any number of times as you cast this spell.)
Everflowing Chalice enters the battlefield with a charge counter on it for each time it was kicked.
{T}: Add {C} for each charge counter on Everflowing Chalice.

Azra Oddsmaker

At the beginning of combat on your turn, you may discard a card. If you do, choose a creature. Whenever that creature deals combat damage to a player this turn, you draw two cards.

Behold the Beyond

Discard your hand. Search your library for three cards, put them into your hand, then shuffle.

Wheel of Misfortune

Each player secretly chooses a number 0 or greater, then all players reveal those numbers simultaneously and determine the highest and lowest numbers revealed this way. Wheel of Misfortune deals damage equal to the highest number to each player who chose that number. Each player who didn't choose the lowest number discards their hand, then draws seven cards.

Sol Ring

Victimize

Choose two target creature cards in your graveyard. Sacrifice a creature. If you do, return the chosen cards to the battlefield tapped.

Astarion's Thirst

Exile target creature. Put X +1/+1 counters on a commander creature you control, where X is the power of the creature exiled this way.

Command Tower

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Swamp

Ancient Copper Dragon

Flying
Whenever Ancient Copper Dragon deals combat damage to a player, roll a d20. You create a number of Treasure tokens equal to the result.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Pawn of Ulamog

Whenever Pawn of Ulamog or another nontoken creature you control dies, you may create a 0/1 colorless Eldrazi Spawn creature token. It has "Sacrifice this creature: Add {C}."

Mortician Beetle

Whenever a player sacrifices a creature, you may put a +1/+1 counter on Mortician Beetle.

Myriad Landscape

Myriad Landscape enters the battlefield tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Criminal Past

Commander creatures you own have menace and "This creature gets +X/+0, where X is the number of creature cards in your graveyard." (A creature with menace can't be blocked except by two or more creatures.)