Grafted Skullcap

At the beginning of your draw step, draw an additional card.
At the beginning of your end step, discard your hand.

Dragon Mage

Flying
Whenever Dragon Mage deals combat damage to a player, each player discards their hand, then draws seven cards.

Gathan Raiders

Hellbent — Gathan Raiders gets +2/+2 as long as you have no cards in hand.
Morph—Discard a card. (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Taste for Mayhem

Enchant creature
Enchanted creature gets +2/+0.
Hellbent — Enchanted creature gets an additional +2/+0 as long as you have no cards in hand.

Blood Scrivener

If you would draw a card while you have no cards in hand, instead you draw two cards and you lose 1 life.

Asylum Visitor

At the beginning of each player's upkeep, if that player has no cards in hand, you draw a card and you lose 1 life.
Madness {1}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

One with Nothing

Tinybones, Trinket Thief

At the beginning of each end step, if an opponent discarded a card this turn, you draw a card and you lose 1 life.
{4}{B}{B}: Each opponent with no cards in hand loses 10 life.

Prickle Faeries

Flying
At the beginning of each opponent's upkeep, if that player has two or fewer cards in hand, Prickle Faeries deals 2 damage to them.

Invasion of Eldraine

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Eldraine enters, target opponent discards two cards.

Invasion of Eldraine // Prickle Faeries

Case of the Crimson Pulse

When this Case enters, discard a card, then draw two cards.
To solve — You have no cards in hand. (If unsolved, solve at the beginning of your end step.)
Solved — At the beginning of your upkeep, discard your hand, then draw two cards.

Cutthroat il-Dal

Hellbent — Cutthroat il-Dal has shadow as long as you have no cards in hand. (It can block or be blocked by only creatures with shadow.)

Fool's Tome

{2}, {T}: Draw a card. Activate only if you have no cards in hand.

Chandra Ablaze

+1: Discard a card. If a red card is discarded this way, Chandra Ablaze deals 4 damage to any target.
−2: Each player discards their hand, then draws three cards.
−7: Cast any number of red instant and/or sorcery cards from your graveyard without paying their mana costs.

Avaricious Dragon

Flying
At the beginning of your draw step, draw an additional card.
At the beginning of your end step, discard your hand.

Wit's End

Mindslicer

When Mindslicer dies, each player discards their hand.

Anthem of Rakdos

Whenever a creature you control attacks, it gets +2/+0 until end of turn and Anthem of Rakdos deals 1 damage to you.
Hellbent — As long as you have no cards in hand, if a source you control would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Twinstrike

Twinstrike deals 2 damage to each of two target creatures.
Hellbent — Destroy those creatures instead if you have no cards in hand.

Wheel of Misfortune

Each player secretly chooses a number 0 or greater, then all players reveal those numbers simultaneously and determine the highest and lowest numbers revealed this way. Wheel of Misfortune deals damage equal to the highest number to each player who chose that number. Each player who didn't choose the lowest number discards their hand, then draws seven cards.

Dark Withering

Destroy target nonblack creature.
Madness {B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Guul Draz Specter

Flying
Guul Draz Specter gets +3/+3 as long as an opponent has no cards in hand.
Whenever Guul Draz Specter deals combat damage to a player, that player discards a card.

Phial of Galadriel

If you would draw a card while you have no cards in hand, draw two cards instead.
If you would gain life while you have 5 or less life, you gain twice that much life instead.
{T}: Add one mana of any color.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Gobhobbler Rats

Hellbent — As long as you have no cards in hand, Gobhobbler Rats gets +1/+0 and has "{B}: Regenerate Gobhobbler Rats." (The next time it would be destroyed this turn, instead tap it, remove it from combat, and heal all damage on it.)

Sire of Insanity

At the beginning of each end step, each player discards their hand.

Connecting the Dots

Whenever a creature you control attacks, exile the top card of your library face down. (You can't look at it.)
{1}{R}, Discard your hand, Sacrifice Connecting the Dots: Put all cards exiled with Connecting the Dots into their owners' hands.

Demon's Jester

Flying
Hellbent — Demon's Jester gets +2/+1 as long as you have no cards in hand.

Null Brooch

{2}, {T}, Discard your hand: Counter target noncreature spell.

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Sarkhan, the Dragonspeaker

+1: Until end of turn, Sarkhan, the Dragonspeaker becomes a legendary 4/4 red Dragon creature with flying, indestructible, and haste. (He doesn't lose loyalty while he's not a planeswalker.)
−3: Sarkhan, the Dragonspeaker deals 4 damage to target creature.
−6: You get an emblem with "At the beginning of your draw step, draw two additional cards" and "At the beginning of your end step, discard your hand."

Paupers' Cage

At the beginning of each opponent's upkeep, if that player has two or fewer cards in hand, Paupers' Cage deals 2 damage to that player.

Stabwhisker the Odious

At the beginning of each opponent's upkeep, that player loses 1 life for each card fewer than three in their hand.

Nezumi Shortfang

{1}{B}, {T}: Target opponent discards a card. Then if that player has no cards in hand, flip Nezumi Shortfang.

Nezumi Shortfang // Stabwhisker the Odious

Shrieking Affliction

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 3 life.

Mindstorm Crown

At the beginning of your upkeep, draw a card if you had no cards in hand at the beginning of this turn. If you had a card in hand, Mindstorm Crown deals 1 damage to you.

Dangerous Wager

Sea Gate Wreckage

{T}: Add {C}. ({C} represents colorless mana.)
{2}{C}, {T}: Draw a card. Activate only if you have no cards in hand.

Nihilistic Glee

{2}{B}, Discard a card: Target opponent loses 1 life and you gain 1 life.
Hellbent — {1}, Pay 2 life: Draw a card. Activate only if you have no cards in hand.

Brink of Madness

At the beginning of your upkeep, if you have no cards in hand, sacrifice Brink of Madness and target opponent discards their hand.

Wheel of Fate

Suspend 4—{1}{R} (Rather than cast this card from your hand, pay {1}{R} and exile it with four time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)
Each player discards their hand, then draws seven cards.

Infernal Tutor

Reveal a card from your hand. Search your library for a card with the same name as that card, reveal it, put it into your hand, then shuffle.
Hellbent — If you have no cards in hand, instead search your library for a card, put it into your hand, then shuffle.

Gibbering Descent

At the beginning of each player's upkeep, that player loses 1 life and discards a card.
Hellbent — Skip your upkeep step if you have no cards in hand.
Madness {2}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Phyrexian Dragon Engine

Double strike
When Phyrexian Dragon Engine enters from your graveyard, you may discard your hand. If you do, draw three cards.
Unearth {3}{R}{R}
(Melds with Mishra, Claimed by Gix.)

Davriel, Rogue Shadowmage

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, Davriel, Rogue Shadowmage deals 2 damage to them.
−1: Target player discards a card.

Rix Maadi, Dungeon Palace

{T}: Add {C}.
{1}{B}{R}, {T}: Each player discards a card. Activate only as a sorcery.

Reforge the Soul

Each player discards their hand, then draws seven cards.
Miracle {1}{R} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Bloodhall Priest

Whenever Bloodhall Priest enters or attacks, if you have no cards in hand, Bloodhall Priest deals 2 damage to any target.
Madness {1}{B}{R} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Temple of the Dead

(Transforms from Aclazotz, Deepest Betrayal.)
{T}: Add {B}.
{2}{B}, {T}: Transform Temple of the Dead. Activate only if a player has one or fewer cards in hand and only as a sorcery.

Aclazotz, Deepest Betrayal

Flying, lifelink
Whenever Aclazotz attacks, each opponent discards a card. For each opponent who can't, you draw a card.
Whenever an opponent discards a land card, create a 1/1 black Bat creature token with flying.
When Aclazotz dies, return it to the battlefield tapped and transformed under its owner's control.

Aclazotz, Deepest Betrayal // Temple of the Dead

Hollowborn Barghest

At the beginning of your upkeep, if you have no cards in hand, each opponent loses 2 life.
At the beginning of each opponent's upkeep, if that player has no cards in hand, they lose 2 life.

Anvil of Bogardan

Players have no maximum hand size.
At the beginning of each player's draw step, that player draws an additional card, then discards a card.

Rakdos Pit Dragon

{R}{R}: Rakdos Pit Dragon gains flying until end of turn.
{R}: Rakdos Pit Dragon gets +1/+0 until end of turn.
Hellbent — Rakdos Pit Dragon has double strike as long as you have no cards in hand.

Magus of the Wheel

{1}{R}, {T}, Sacrifice Magus of the Wheel: Each player discards their hand, then draws seven cards.

Headless Specter

Flying
Hellbent — Whenever Headless Specter deals combat damage to a player, if you have no cards in hand, that player discards a card at random.

Immersturm Skullcairn

Immersturm Skullcairn enters tapped.
{T}: Add {B}.
{1}{B}{R}{R}, {T}, Sacrifice Immersturm Skullcairn: It deals 3 damage to target player. That player discards a card. Activate only as a sorcery.

Carnage Interpreter

When Carnage Interpreter enters, discard your hand, then investigate four times. (To investigate, create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
As long as you have one or fewer cards in hand, Carnage Interpreter gets +2/+2 and has menace.

Hellfire Mongrel

At the beginning of each opponent's upkeep, if that player has two or fewer cards in hand, Hellfire Mongrel deals 2 damage to that player.

Jagged Poppet

Whenever Jagged Poppet is dealt damage, discard that many cards.
Hellbent — Whenever Jagged Poppet deals combat damage to a player, if you have no cards in hand, that player discards cards equal to the damage.

Lavaborn Muse

At the beginning of each opponent's upkeep, if that player has two or fewer cards in hand, Lavaborn Muse deals 3 damage to that player.

Terminal Agony

Destroy target creature.
Madness {B}{R} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Tragic Fall

Target creature gets -3/-3 until end of turn.
Hellbent — That creature gets -13/-13 until end of turn instead if you have no cards in hand.

Curse of Obsession

Enchant player
At the beginning of enchanted player's draw step, that player draws two additional cards.
At the beginning of enchanted player's end step, that player discards their hand.

Ghirapur Orrery

Each player may play an additional land on each of their turns.
At the beginning of each player's upkeep, if that player has no cards in hand, that player draws three cards.