Go for the Throat

Don't Have

Dreg Recycler

{T}, Sacrifice an artifact or creature: Each opponent loses 1 life and you gain 1 life.

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Lich-Knights' Conquest

Sacrifice any number of artifacts, enchantments, and/or tokens. Return that many creature cards from your graveyard to the battlefield.

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Evolving Wilds

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Orzhov Signet

Teysa Karlov

If a creature dying causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.
Creature tokens you control have vigilance and lifelink.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Staff of the Storyteller

When Staff of the Storyteller enters, create a 1/1 white Spirit creature token with flying.
Whenever you create one or more creature tokens, put a story counter on Staff of the Storyteller.
{W}, {T}, Remove a story counter from Staff of the Storyteller: Draw a card.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Despark

Exile target permanent with mana value 4 or greater.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Viscera Seer

Sacrifice a creature: Scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Teysa, Opulent Oligarch

Deathtouch
At the beginning of your end step, investigate for each opponent who lost life this turn.
Whenever a Clue you control is put into a graveyard from the battlefield, create a 1/1 white and black Spirit creature token with flying. This ability triggers only once each turn.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Wispdrinker Vampire

Flying
Whenever another creature you control with power 2 or less enters, each opponent loses 1 life and you gain 1 life.
{5}{W}{B}: Creatures you control with power 2 or less gain deathtouch and lifelink until end of turn.

Pitiless Plunderer

Whenever another creature you control dies, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Bartolomé del Presidio

Sacrifice another creature or artifact: Put a +1/+1 counter on Bartolomé del Presidio.

Command Tower

Acolyte of Aclazotz

{T}, Sacrifice another creature or artifact: Each opponent loses 1 life and you gain 1 life.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Not Dead After All

Until end of turn, target creature you control gains "When this creature dies, return it to the battlefield tapped under its owner's control, then create a Wicked Role token attached to it." (Enchanted creature gets +1/+1. When this Aura is put into a graveyard, each opponent loses 1 life.)

Fracture

Destroy target artifact, enchantment, or planeswalker.

Teysa, Orzhov Scion

Sacrifice three white creatures: Exile target creature.
Whenever another black creature you control dies, create a 1/1 white Spirit creature token with flying.

Grimclimb Pathway

Brightclimb Pathway

Brightclimb Pathway // Grimclimb Pathway

Wojek Investigator

Flying, vigilance
At the beginning of your upkeep, investigate once for each opponent who has more cards in hand than you. (To investigate, create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Fanatical Offering

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Map token. (It's an artifact with "{1}, {T}, Sacrifice this artifact: Target creature you control explores. Activate only as a sorcery.")

Havengul Mystery

When this land transforms into Havengul Mystery, return target creature card from your graveyard to the battlefield.
When the creature put onto the battlefield with Havengul Mystery leaves the battlefield, transform Havengul Mystery.
{T}, Pay 1 life: Add {B}.

Havengul Laboratory

{T}: Add {C}.
{4}, {T}: Investigate. (Create a colorless Clue artifact token with "{2}, Sacrifice this artifact: Draw a card.")
At the beginning of your end step, if you sacrificed three or more Clues this turn, transform Havengul Laboratory.

Havengul Laboratory // Havengul Mystery

Grinding Station

{T}, Sacrifice an artifact: Target player mills three cards.
Whenever an artifact enters, you may untap Grinding Station.

Bone Splinters

As an additional cost to cast this spell, sacrifice a creature.
Destroy target creature.

Sol Ring

filler

Village Rites

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

Academy Manufactor

If you would create a Clue, Food, or Treasure token, instead create one of each.

Intangible Virtue

Creature tokens you control get +1/+1 and have vigilance.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Nadier's Nightblade

Whenever a token you control leaves the battlefield, each opponent loses 1 life and you gain 1 life.

Animate Dead

Enchant creature card in a graveyard
When Animate Dead enters, if it's on the battlefield, it loses "enchant creature card in a graveyard" and gains "enchant creature put onto the battlefield with Animate Dead." Return enchanted creature card to the battlefield under your control and attach Animate Dead to it. When Animate Dead leaves the battlefield, that creature's controller sacrifices it.
Enchanted creature gets -1/-0.

Wernog, Rider's Chaplain

When Wernog, Rider's Chaplain enters or leaves the battlefield, each opponent may investigate. Each opponent who doesn't loses 1 life. You investigate X times, where X is one plus the number of opponents who investigated this way.
Friends forever (You can have two commanders if both have friends forever.)

Thorough Investigation

Whenever you attack, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
Whenever you sacrifice a Clue, venture into the dungeon. (Enter the first room or advance to the next room.)

Search the Premises

Whenever a creature attacks you or a planeswalker you control, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Vito, Fanatic of Aclazotz

Flying
Whenever you sacrifice another permanent, you gain 2 life if this is the first time this ability has resolved this turn. If it's the second time, each opponent loses 2 life. If it's the third time, create a 4/3 white and black Vampire Demon creature token with flying.

Plains

Takenuma, Abandoned Mire

{T}: Add {B}.
Channel — {3}{B}, Discard Takenuma, Abandoned Mire: Mill three cards, then return a creature or planeswalker card from your graveyard to your hand. This ability costs {1} less to activate for each legendary creature you control.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Mortify

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Bygone Bishop

Flying
Whenever you cast a creature spell with mana value 3 or less, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Ashnod's Altar

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Homicide Investigator

Whenever one or more nontoken creatures you control die, investigate. This ability triggers only once each turn. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Inspiring Statuary

Nonartifact spells you cast have improvise. (Your artifacts can help cast those spells. Each artifact you tap after you're done activating mana abilities pays for {1}.)

Swamp

Persuasive Interrogators

When Persuasive Interrogators enters, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
Whenever you sacrifice a Clue, target opponent gets two poison counters. (A player with ten or more poison counters loses the game.)

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Beseech the Mirror

Bargain (You may sacrifice an artifact, enchantment, or token as you cast this spell.)
Search your library for a card, exile it face down, then shuffle. If this spell was bargained, you may cast the exiled card without paying its mana cost if that spell's mana value is 4 or less. Put the exiled card into your hand if it wasn't cast this way.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Novice Inspector

When Novice Inspector enters, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Dark Ritual

Corpse Knight

Whenever another creature you control enters, each opponent loses 1 life.

Disciple of the Vault

Whenever an artifact is put into a graveyard from the battlefield, you may have target opponent lose 1 life.

Vault of the Archangel

{T}: Add {C}.
{2}{W}{B}, {T}: Creatures you control gain deathtouch and lifelink until end of turn.

Fetid Heath

{T}: Add {C}.
{W/B}, {T}: Add {W}{W}, {W}{B}, or {B}{B}.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Agent of the Iron Throne

Commander creatures you own have "Whenever an artifact or creature you control is put into a graveyard from the battlefield, each opponent loses 1 life."

Sanctum of Stone Fangs

At the beginning of your first main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Ophiomancer

At the beginning of each upkeep, if you control no Snakes, create a 1/1 black Snake creature token with deathtouch.