Yawgmoth, Thran Physician

Protection from Humans
Pay 1 life, Sacrifice another creature: Put a -1/-1 counter on up to one target creature and draw a card.
{B}{B}, Discard a card: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Talisman of Progress

{T}: Add {C}.
{T}: Add {W} or {U}. Talisman of Progress deals 1 damage to you.

Castle Ardenvale

Castle Ardenvale enters the battlefield tapped unless you control a Plains.
{T}: Add {W}.
{2}{W}{W}, {T}: Create a 1/1 white Human creature token.

Hallowed Fountain

({T}: Add {W} or {U}.)
As Hallowed Fountain enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Castle Locthwain

Castle Locthwain enters the battlefield tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Evolving Wilds

{T}, Sacrifice Evolving Wilds: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Arcane Sanctum

Arcane Sanctum enters the battlefield tapped.
{T}: Add {W}, {U}, or {B}.

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Mana Crypt

At the beginning of your upkeep, flip a coin. If you lose the flip, Mana Crypt deals 3 damage to you.
{T}: Add {C}{C}.

Bastion of Remembrance

When Bastion of Remembrance enters the battlefield, create a 1/1 white Human Soldier creature token.
Whenever a creature you control dies, each opponent loses 1 life and you gain 1 life.

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Island

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Spire of Industry

{T}: Add {C}.
{T}, Pay 1 life: Add one mana of any color. Activate only if you control an artifact.

Viscera Seer

Sacrifice a creature: Scry 1. (Look at the top card of your library. You may put that card on the bottom of your library.)

Elas il-Kor, Sadistic Pilgrim

Deathtouch
Whenever another creature enters the battlefield under your control, you gain 1 life.
Whenever another creature you control dies, each opponent loses 1 life.

Erebos, Bleak-Hearted

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature.
Whenever another creature you control dies, you may pay 2 life. If you do, draw a card.
{1}{B}, Sacrifice another creature: Target creature gets -2/-1 until end of turn.

Auriok Champion

Protection from black and from red
Whenever another creature enters the battlefield, you may gain 1 life.

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Ajani, Strength of the Pride

+1: You gain life equal to the number of creatures you control plus the number of planeswalkers you control.
−2: Create a 2/2 white Cat Soldier creature token named Ajani's Pridemate with "Whenever you gain life, put a +1/+1 counter on Ajani's Pridemate."
0: If you have at least 15 life more than your starting life total, exile Ajani, Strength of the Pride and each artifact and creature your opponents control.

Void Rend

This spell can't be countered.
Destroy target nonland permanent.

Counterspell

The One Ring

Indestructible
When The One Ring enters the battlefield, if you cast it, you gain protection from everything until your next turn.
At the beginning of your upkeep, you lose 1 life for each burden counter on The One Ring.
{T}: Put a burden counter on The One Ring, then draw a card for each burden counter on The One Ring.

Swamp

Karlov of the Ghost Council

Whenever you gain life, put two +1/+1 counters on Karlov of the Ghost Council.
{W}{B}, Remove six +1/+1 counters from Karlov of the Ghost Council: Exile target creature.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Serra Paragon

Flying
Once during each of your turns, you may play a land from your graveyard or cast a permanent spell with mana value 3 or less from your graveyard. If you do, it gains "When this permanent is put into a graveyard from the battlefield, exile it and you gain 2 life."

Labyrinth of Skophos

{T}: Add {C}.
{4}, {T}: Remove target attacking or blocking creature from combat.

Bloodstained Mire

{T}, Pay 1 life, Sacrifice Bloodstained Mire: Search your library for a Swamp or Mountain card, put it onto the battlefield, then shuffle.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Inventors' Fair

At the beginning of your upkeep, if you control three or more artifacts, you gain 1 life.
{T}: Add {C}.
{4}, {T}, Sacrifice Inventors' Fair: Search your library for an artifact card, reveal it, put it into your hand, then shuffle. Activate only if you control three or more artifacts.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Soul Warden

Whenever another creature enters the battlefield, you gain 1 life.

Essence Pulse

You gain 2 life. Each creature gets -X/-X until end of turn, where X is the amount of life you gained this turn.

Sol Ring

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Command Tower

Suture Priest

Whenever another creature enters the battlefield under your control, you may gain 1 life.
Whenever a creature enters the battlefield under an opponent's control, you may have that player lose 1 life.

Ghostway

Exile each creature you control. Return those cards to the battlefield under their owner's control at the beginning of the next end step.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Glass-Cast Heart

Whenever one or more Vampires you control attack, create a Blood token. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this artifact: Draw a card.")
{B}, {T}, Pay 1 life: Create a 1/1 white and black Vampire creature token with lifelink.
{B}{B}, {T}, Sacrifice Glass-Cast Heart and thirteen Blood tokens: Each opponent loses 13 life and you gain 13 life.

Sevinne's Reclamation

Return target permanent card with mana value 3 or less from your graveyard to the battlefield. If this spell was cast from a graveyard, you may copy this spell and may choose a new target for the copy.
Flashback {4}{W} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Welcoming Vampire

Flying
Whenever one or more other creatures with power 2 or less enter the battlefield under your control, draw a card. This ability triggers only once each turn.

Flooded Strand

{T}, Pay 1 life, Sacrifice Flooded Strand: Search your library for a Plains or Island card, put it onto the battlefield, then shuffle.

Watery Grave

({T}: Add {U} or {B}.)
As Watery Grave enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Prairie Stream

({T}: Add {W} or {U}.)
Prairie Stream enters the battlefield tapped unless you control two or more basic lands.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Temple of Silence

Temple of Silence enters the battlefield tapped.
When Temple of Silence enters the battlefield, scry 1.
{T}: Add {W} or {B}.

Black Market Connections

At the beginning of your precombat main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Temple of Enlightenment

Temple of Enlightenment enters the battlefield tapped.
When Temple of Enlightenment enters the battlefield, scry 1.
{T}: Add {W} or {U}.

Temple of Deceit

Temple of Deceit enters the battlefield tapped.
When Temple of Deceit enters the battlefield, scry 1.
{T}: Add {U} or {B}.

Raffine's Tower

({T}: Add {W}, {U}, or {B}.)
Raffine's Tower enters the battlefield tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Cruel Celebrant

Whenever Cruel Celebrant or another creature or planeswalker you control dies, each opponent loses 1 life and you gain 1 life.

Creeping Inn

Whenever Creeping Inn attacks, you may exile a creature card from your graveyard. If you do, each opponent loses X life and you gain X life, where X is the number of creature cards exiled with Creeping Inn.
{4}: Creeping Inn phases out.

Hostile Hostel

{T}: Add {C}.
{1}, {T}, Sacrifice a creature: Put a soul counter on Hostile Hostel. Then if there are three or more soul counters on it, remove those counters, transform it, then untap it. Activate only as a sorcery.

Hostile Hostel // Creeping Inn

Sword of Forge and Frontier

Equipped creature gets +2/+2 and has protection from red and from green.
Whenever equipped creature deals combat damage to a player, exile the top two cards of your library. You may play those cards this turn. You may play an additional land this turn.
Equip {2}

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

High Market

{T}: Add {C}.
{T}, Sacrifice a creature: You gain 1 life.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Fabled Passage

{T}, Sacrifice Fabled Passage: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle. Then if you control four or more lands, untap that land.

Dire Tactics

Exile target creature. If you don't control a Human, you lose life equal to that creature's toughness.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Pristine Talisman

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Polluted Delta

{T}, Pay 1 life, Sacrifice Polluted Delta: Search your library for an Island or Swamp card, put it onto the battlefield, then shuffle.

Solemn Simulacrum

When Solemn Simulacrum enters the battlefield, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When Solemn Simulacrum dies, you may draw a card.

Sword of Light and Shadow

Equipped creature gets +2/+2 and has protection from white and from black.
Whenever equipped creature deals combat damage to a player, you gain 3 life and you may return up to one target creature card from your graveyard to your hand.
Equip {2}

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Night's Whisper

Soul's Attendant

Whenever another creature enters the battlefield, you may gain 1 life.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature and you return up to one target creature card from your graveyard to your hand.

Heliod, Sun-Crowned

Indestructible
As long as your devotion to white is less than five, Heliod isn't a creature.
Whenever you gain life, put a +1/+1 counter on target creature or enchantment you control.
{1}{W}: Another target creature gains lifelink until end of turn.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Isolated Chapel

Isolated Chapel enters the battlefield tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Attended Healer

Whenever you gain life for the first time each turn, create a 1/1 white Cat creature token.
{2}{W}: Another target Cleric gains lifelink until end of turn.

Liliana, Dreadhorde General

Whenever a creature you control dies, draw a card.
+1: Create a 2/2 black Zombie creature token.
−4: Each player sacrifices two creatures.
−9: Each opponent chooses a permanent they control of each permanent type and sacrifices the rest.

Oloro, Ageless Ascetic

At the beginning of your upkeep, you gain 2 life.
Whenever you gain life, you may pay {1}. If you do, draw a card and each opponent loses 1 life.
At the beginning of your upkeep, if Oloro, Ageless Ascetic is in the command zone, you gain 2 life.

Plains

Sunken Hollow

({T}: Add {U} or {B}.)
Sunken Hollow enters the battlefield tapped unless you control two or more basic lands.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Elesh Norn, Grand Cenobite

Vigilance
Other creatures you control get +2/+2.
Creatures your opponents control get -2/-2.

Regal Bloodlord

Flying
At the beginning of each end step, if you gained life this turn, create a 1/1 black Bat creature token with flying.

Redemption Choir

Lifelink
Coven — Whenever Redemption Choir enters the battlefield or attacks, if you control three or more creatures with different powers, return target permanent card with mana value 3 or less from your graveyard to the battlefield.

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Indulging Patrician

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your end step, if you gained 3 or more life this turn, each opponent loses 3 life.

Ayli, Eternal Pilgrim

Deathtouch
{1}, Sacrifice another creature: You gain life equal to the sacrificed creature's toughness.
{1}{W}{B}, Sacrifice another creature: Exile target nonland permanent. Activate only if you have at least 10 life more than your starting life total.