Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Elder Brain

Menace
Whenever Elder Brain attacks a player, exile all cards from that player's hand, then they draw that many cards. You may play lands and cast spells from among the exiled cards for as long as they remain exiled. If you cast a spell this way, you may spend mana as though it were mana of any color to cast it.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Beseech the Queen

({2/B} can be paid with any two mana or with {B}. This card's mana value is 6.)
Search your library for a card with mana value less than or equal to the number of lands you control, reveal it, put it into your hand, then shuffle.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Ambition's Cost

You draw three cards and you lose 3 life.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Jet Medallion

Black spells you cast cost {1} less to cast.

Lotus Petal

{T}, Sacrifice Lotus Petal: Add one mana of any color.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Dark Ritual

Praetor's Grasp

Search target opponent's library for a card and exile it face down. Then that player shuffles. You may look at and play that card for as long as it remains exiled.

Temporal Extortion

When you cast this spell, any player may pay half their life, rounded up. If a player does, counter Temporal Extortion.
Take an extra turn after this one.

Orcish Bowmasters

Flash
When Orcish Bowmasters enters the battlefield and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Ancient Tomb

{T}: Add {C}{C}. Ancient Tomb deals 2 damage to you.

Spellbook

No Mercy

Whenever a creature deals damage to you, destroy it.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Sensei's Divining Top

{1}: Look at the top three cards of your library, then put them back in any order.
{T}: Draw a card, then put Sensei's Divining Top on top of its owner's library.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Strip Mine

{T}: Add {C}.
{T}, Sacrifice Strip Mine: Destroy target land.

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

Pain's Reward

Each player may bid life. You start the bidding with a bid of any number. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and draws four cards.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Mana Vault

Mana Vault doesn't untap during your untap step.
At the beginning of your upkeep, you may pay {4}. If you do, untap Mana Vault.
At the beginning of your draw step, if Mana Vault is tapped, it deals 1 damage to you.
{T}: Add {C}{C}{C}.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters the battlefield, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Jeweled Lotus

{T}, Sacrifice Jeweled Lotus: Add three mana of any one color. Spend this mana only to cast your commander.

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Sol Ring

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Read the Bones

Scry 2, then draw two cards. You lose 2 life.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Black Market Connections

At the beginning of your precombat main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Chrome Mox

Imprint — When Chrome Mox enters the battlefield, you may exile a nonartifact, nonland card from your hand.
{T}: Add one mana of any of the exiled card's colors.

Stinging Study

You draw X cards and you lose X life, where X is the mana value of a commander you own on the battlefield or in the command zone.

Takenuma, Abandoned Mire

{T}: Add {B}.
Channel — {3}{B}, Discard Takenuma, Abandoned Mire: Mill three cards, then return a creature or planeswalker card from your graveyard to your hand. This ability costs {1} less to activate for each legendary creature you control.

Dauthi Voidwalker

Shadow (This creature can block or be blocked by only creatures with shadow.)
If a card would be put into an opponent's graveyard from anywhere, instead exile it with a void counter on it.
{T}, Sacrifice Dauthi Voidwalker: Choose an exiled card an opponent owns with a void counter on it. You may play it this turn without paying its mana cost.

Urza's Saga

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Urza's Saga gains "{T}: Add {C}."
II — Urza's Saga gains "{2}, {T}: Create a 0/0 colorless Construct artifact creature token with 'This creature gets +1/+1 for each artifact you control.'"
III — Search your library for an artifact card with mana cost {0} or {1}, put it onto the battlefield, then shuffle.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Diabolic Intent

As an additional cost to cast this spell, sacrifice a creature.
Search your library for a card, put that card into your hand, then shuffle.

Pact of the Serpent

Choose a creature type. Target player draws X cards and loses X life, where X is the number of creatures they control of the chosen type.

Sickening Dreams

As an additional cost to cast this spell, discard X cards.
Sickening Dreams deals X damage to each creature and each player.

Polluted Bonds

Whenever a land enters the battlefield under an opponent's control, that player loses 2 life and you gain 2 life.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Memory Jar

{T}, Sacrifice Memory Jar: Each player exiles all cards from their hand face down and draws seven cards. At the beginning of the next end step, each player discards their hand and returns to their hand each card they exiled this way.

Mana Crypt

At the beginning of your upkeep, flip a coin. If you lose the flip, Mana Crypt deals 3 damage to you.
{T}: Add {C}{C}.

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Anvil of Bogardan

Players have no maximum hand size.
At the beginning of each player's draw step, that player draws an additional card, then discards a card.

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Arcane Signet

Painful Lesson

Target player draws two cards and loses 2 life.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Swamp

Temple of the Dead

(Transforms from Aclazotz, Deepest Betrayal.)
{T}: Add {B}.
{2}{B}, {T}: Transform Temple of the Dead. Activate only if a player has one or fewer cards in hand and only as a sorcery.

Aclazotz, Deepest Betrayal

Flying, lifelink
Whenever Aclazotz attacks, each opponent discards a card. For each opponent who can't, you draw a card.
Whenever an opponent discards a land card, create a 1/1 black Bat creature token with flying.
When Aclazotz dies, return it to the battlefield tapped and transformed under its owner's control.

Aclazotz, Deepest Betrayal // Temple of the Dead

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.