Gonti's Machinations

Whenever you lose life for the first time each turn, you get {E}. (You get an energy counter. Damage causes loss of life.)
Pay {E}{E}, Sacrifice Gonti's Machinations: Each opponent loses 3 life. You gain life equal to the life lost this way.

Caress of Phyrexia

Target player draws three cards, loses 3 life, and gets three poison counters.

Zof Bloodbog

Zof Bloodbog enters tapped.
{T}: Add {B}.

Zof Consumption

Each opponent loses 4 life and you gain 4 life.

Zof Consumption // Zof Bloodbog

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Dark Favor

Enchant creature
When Dark Favor enters, you lose 1 life.
Enchanted creature gets +3/+1.

Arrogant Outlaw

When Arrogant Outlaw enters, if an opponent lost life this turn, each opponent loses 2 life and you gain 2 life.

Ambition's Cost

You draw three cards and you lose 3 life.

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Venser's Journal

You have no maximum hand size.
At the beginning of your upkeep, you gain 1 life for each card in your hand.

Obscura Storefront

When Obscura Storefront enters, sacrifice it. When you do, search your library for a basic Plains, Island, or Swamp card, put it onto the battlefield tapped, then shuffle and you gain 1 life.

Absorb Vis

Target player loses 4 life and you gain 4 life.
Basic landcycling {1}{B} ({1}{B}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Decanter of Endless Water

You have no maximum hand size.
{T}: Add one mana of any color.

Diamond Mare

As Diamond Mare enters, choose a color.
Whenever you cast a spell of the chosen color, you gain 1 life.

Vampire Scrivener

Flying
Whenever you gain life during your turn, put a +1/+1 counter on Vampire Scrivener.
Whenever you lose life during your turn, put a +1/+1 counter on Vampire Scrivener.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Lich's Tomb

You don't lose the game for having 0 or less life.
Whenever you lose life, sacrifice a permanent for each 1 life you lost. (Damage causes loss of life.)

Archetype of Finality

Creatures you control have deathtouch.
Creatures your opponents control lose deathtouch and can't have or gain deathtouch.

Faith of the Devoted

Whenever you cycle or discard a card, you may pay {1}. If you do, each opponent loses 2 life and you gain 2 life.

Braidwood Cup

Ancient Craving

Circle of Affliction

As Circle of Affliction enters, choose a color.
Whenever a source of the chosen color deals damage to you, you may pay {1}. If you do, target player loses 1 life and you gain 1 life.

Sorin the Mirthless

+1: Look at the top card of your library. You may reveal that card and put it into your hand. If you do, you lose life equal to its mana value.
−2: Create a 2/3 black Vampire creature token with flying and lifelink.
−7: Sorin the Mirthless deals 13 damage to any target. You gain 13 life.

Feast of Sanity

Whenever you discard a card, Feast of Sanity deals 1 damage to any target and you gain 1 life.

Spellbook

Agonizing Remorse

Target opponent reveals their hand. You choose a nonland card from it or a card from their graveyard. Exile that card. You lose 1 life.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Riveteers Overlook

When Riveteers Overlook enters, sacrifice it. When you do, search your library for a basic Swamp, Mountain, or Forest card, put it onto the battlefield tapped, then shuffle and you gain 1 life.

Ruin Raider

Raid — At the beginning of your end step, if you attacked this turn, reveal the top card of your library and put that card into your hand. You lose life equal to the card's mana value.

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Blood Pact

Target player draws two cards and loses 2 life.

Demon's Horn

Whenever a player casts a black spell, you may gain 1 life.

Caustic Tar

Enchant land
Enchanted land has "{T}: Target player loses 3 life."

Abattoir Ghoul

First strike
Whenever a creature dealt damage by Abattoir Ghoul this turn dies, you gain life equal to that creature's toughness.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Skirge Familiar

Vengeful Warchief

Whenever you lose life for the first time each turn, put a +1/+1 counter on Vengeful Warchief. (Damage causes loss of life.)

Audacious Thief

Whenever Audacious Thief attacks, you draw a card and you lose 1 life.

Dark Tutelage

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Druidic Satchel

{2}, {T}: Reveal the top card of your library. If it's a creature card, create a 1/1 green Saproling creature token. If it's a land card, put that card onto the battlefield under your control. If it's a noncreature, nonland card, you gain 2 life.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Angelheart Vial

Whenever you're dealt damage, you may put that many charge counters on Angelheart Vial.
{2}, {T}, Remove four charge counters from Angelheart Vial: You gain 2 life and draw a card.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Chainer's Torment

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I, II — Chainer's Torment deals 2 damage to each opponent and you gain 2 life.
III — Create an X/X black Nightmare Horror creature token, where X is half your life total, rounded up. It deals X damage to you.

Pain Seer

Inspired — Whenever Pain Seer becomes untapped, reveal the top card of your library and put that card into your hand. You lose life equal to that card's mana value.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Campfire

{1}, {T}: You gain 2 life.
{2}, {T}, Exile Campfire: Put all commanders you own from the command zone and from your graveyard into your hand. Then shuffle your graveyard into your library.

Flensermite

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Treacherous Blessing

When Treacherous Blessing enters, draw three cards.
Whenever you cast a spell, you lose 1 life.
When Treacherous Blessing becomes the target of a spell or ability, sacrifice it.

Brokers Hideout

When Brokers Hideout enters, sacrifice it. When you do, search your library for a basic Forest, Plains, or Island card, put it onto the battlefield tapped, then shuffle and you gain 1 life.

Night's Whisper

Blood Scrivener

If you would draw a card while you have no cards in hand, instead you draw two cards and you lose 1 life.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Swamp

Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

Cabaretti Courtyard

When Cabaretti Courtyard enters, sacrifice it. When you do, search your library for a basic Mountain, Forest, or Plains card, put it onto the battlefield tapped, then shuffle and you gain 1 life.

Ghastly Death Tyrant

When Ghastly Death Tyrant enters, choose one —
• Disintegration Ray — Destroy target enchantment an opponent controls. You lose life equal to its mana value.
• Death Ray — Creatures you control gain deathtouch until end of turn.

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Phyrexian Delver

When Phyrexian Delver enters, return target creature card from your graveyard to the battlefield. You lose life equal to that card's mana value.

Vislor Turlough

Deal with the Black Guardian — When Vislor Turlough enters, you may have an opponent gain control of it. If you do, it's goaded for as long as they control it.
At the beginning of your end step, draw a card, then you lose life equal to the number of cards in your hand.
Doctor's companion (You can have two commanders if the other is the Doctor.)