Exotic Disease

Domain — Target player loses X life and you gain X life, where X is the number of basic land types among lands you control.

Diregraf Ghoul

Evolved Sleeper

{B}: Evolved Sleeper becomes a Human Cleric with base power and toughness 2/2.
{1}{B}: If Evolved Sleeper is a Cleric, put a deathtouch counter on it and it becomes a Phyrexian Human Cleric with base power and toughness 3/3.
{1}{B}{B}: If Evolved Sleeper is a Phyrexian, put a +1/+1 counter on it, then you draw a card and you lose 1 life.

Tendrils of Agony

Target player loses 2 life and you gain 2 life.
Storm (When you cast this spell, copy it for each spell cast before it this turn. You may choose new targets for the copies.)

Glint-Sleeve Siphoner

Menace
Whenever Glint-Sleeve Siphoner enters or attacks, you get {E} (an energy counter).
At the beginning of your upkeep, you may pay {E}{E}. If you do, you draw a card and you lose 1 life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Corrupt

Corrupt deals damage to any target equal to the number of Swamps you control. You gain life equal to the damage dealt this way.

Pain Seer

Inspired — Whenever Pain Seer becomes untapped, reveal the top card of your library and put that card into your hand. You lose life equal to that card's mana value.

Fruit of Tizerus

Target player loses 2 life.
Escape—{3}{B}, Exile three other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)

Great Unclean One

Reverberating Summons — At the beginning of your end step, each opponent loses 2 life. Then for each opponent who has less life than you, create a 1/3 black Demon creature token named Plaguebearer of Nurgle.

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When Gixian Puppeteer dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Calculating Lich

Menace
Whenever a creature attacks one of your opponents, that player loses 1 life.

Vampire's Kiss

Target player loses 2 life and you gain 2 life. Create two Blood tokens. (They're artifacts with "{1}, {T}, Discard a card, Sacrifice this artifact: Draw a card.")

Reckless Spite

Destroy two target nonblack creatures. You lose 5 life.

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Vermin Gorger

{T}, Sacrifice another creature: Each opponent loses 2 life and you gain 2 life.

Gutterbones

Gutterbones enters tapped.
{1}{B}: Return Gutterbones from your graveyard to your hand. Activate only during your turn and only if an opponent lost life this turn.

Isareth the Awakener

Deathtouch
Whenever Isareth the Awakener attacks, you may pay {X}. When you do, return target creature card with mana value X from your graveyard to the battlefield with a corpse counter on it. If that creature would leave the battlefield, exile it instead of putting it anywhere else.

Covenant of Blood

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Covenant of Blood deals 4 damage to any target and you gain 4 life.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Gelatinous Cube

Engulf — When Gelatinous Cube enters, exile target non-Ooze creature an opponent controls until Gelatinous Cube leaves the battlefield.
Dissolve — {X}{B}: Put target creature card with mana value X exiled with Gelatinous Cube into its owner's graveyard.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters, each player loses a third of their life, rounded up.

Infernal Grasp

Destroy target creature. You lose 2 life.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Savage Gorger

Flying
At the beginning of your end step, if an opponent lost life this turn, put a +1/+1 counter on Savage Gorger. (Damage causes loss of life.)

Smiting Helix

Smiting Helix deals 3 damage to any target and you gain 3 life.
Flashback {R}{W} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Preacher of the Schism

Deathtouch
Whenever Preacher of the Schism attacks the player with the most life or tied for most life, create a 1/1 white Vampire creature token with lifelink.
Whenever Preacher of the Schism attacks while you have the most life or are tied for most life, you draw a card and you lose 1 life.

Overseer of the Damned

Flying
When Overseer of the Damned enters, you may destroy target creature.
Whenever a nontoken creature an opponent controls dies, create a tapped 2/2 black Zombie creature token.

Ophiomancer

At the beginning of each upkeep, if you control no Snakes, create a 1/1 black Snake creature token with deathtouch.

Parasitic Grasp

Cleave {1}{B}{B} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Parasitic Grasp deals 3 damage to target [Human] creature. You gain 3 life.

Soul Feast

Target player loses 4 life and you gain 4 life.

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Bloodsoaked Champion

Bloodsoaked Champion can't block.
Raid — {1}{B}: Return Bloodsoaked Champion from your graveyard to the battlefield. Activate only if you attacked this turn.

Drana, Liberator of Malakir

Flying, first strike
Whenever Drana, Liberator of Malakir deals combat damage to a player, put a +1/+1 counter on each attacking creature you control.

Fatal Push

Destroy target creature if it has mana value 2 or less.
Revolt — Destroy that creature if it has mana value 4 or less instead if a permanent you controlled left the battlefield this turn.

Distress

Target player reveals their hand. You choose a nonland card from it. That player discards that card.

Blood Scrivener

If you would draw a card while you have no cards in hand, instead you draw two cards and you lose 1 life.

Guul Draz Vampire

As long as an opponent has 10 or less life, Guul Draz Vampire gets +2/+1 and has intimidate. (It can't be blocked except by artifact creatures and/or creatures that share a color with it.)

Basilica Screecher

Flying
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Essence Harvest

Target player loses X life and you gain X life, where X is the greatest power among creatures you control.

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Sovereign's Bite

Target player loses 3 life and you gain 3 life.

Swift End

Destroy target creature or planeswalker. You lose 2 life. (Then exile this card. You may cast the creature later from exile.)

Murderous Rider

Lifelink
When Murderous Rider dies, put it on the bottom of its owner's library.

Murderous Rider // Swift End

Vicious Conquistador

Whenever Vicious Conquistador attacks, each opponent loses 1 life.

Hideous End

Destroy target nonblack creature. Its controller loses 2 life.

Ulcerate

Target creature gets -3/-3 until end of turn. You lose 3 life.

Sedgemoor Witch

Menace
Ward—Pay 3 life. (Whenever this creature becomes the target of a spell or ability an opponent controls, counter it unless that player pays 3 life.)
Magecraft — Whenever you cast or copy an instant or sorcery spell, create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."

Blightwing Bandit

Flying, deathtouch
Whenever you cast your first spell during each opponent's turn, look at the top card of that player's library, then exile it face down. You may play that card for as long as it remains exiled, and mana of any type can be spent to cast it.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Faerie Dreamthief

Flying
When Faerie Dreamthief enters, surveil 1. (Look at the top card of your library. You may put it into your graveyard.)
{2}{B}, Exile Faerie Dreamthief from your graveyard: You draw a card and you lose 1 life.

Shard of the Nightbringer

Flying
Drain Life — When Shard of the Nightbringer enters, if you cast it, target opponent loses half their life, rounded up. You gain life equal to the life lost this way.

High Fae Negotiator

Bargain (You may sacrifice an artifact, enchantment, or token as you cast this spell.)
Flying
When High Fae Negotiator enters, if it was bargained, each opponent loses 3 life and you gain 3 life.

Asylum Visitor

At the beginning of each player's upkeep, if that player has no cards in hand, you draw a card and you lose 1 life.
Madness {1}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Drana, the Last Bloodchief

Flying
Whenever Drana, the Last Bloodchief attacks, defending player chooses a nonlegendary creature card in your graveyard. You return that card to the battlefield with an additional +1/+1 counter on it. The creature is a Vampire in addition to its other types.

Homicide Investigator

Whenever one or more nontoken creatures you control die, investigate. This ability triggers only once each turn. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Lay Bare the Heart

Target opponent reveals their hand. You choose a nonlegendary, nonland card from it. That player discards that card.