Have

Officious Interrogation

This spell costs {W}{U} more to cast for each target beyond the first.
Choose any number of target players. Investigate X times, where X is the total number of creatures those players control.

Duggan, Private Detective

Duggan's power and toughness are each equal to the number of cards in your hand.
Whenever Duggan enters or attacks, investigate.
The Most Important Punch in History — {1}{G}, {T}: Duggan deals damage equal to twice its power to another target creature. Activate only once.

Don't Have

Lonis, Genetics Expert

Evolve (Whenever a creature you control enters, if that creature has greater power or toughness than this creature, put a +1/+1 counter on this creature.)
Whenever one or more +1/+1 counters are put on Lonis, investigate that many times.
Whenever you sacrifice a Clue, put a +1/+1 counter on another target creature you control.

Tamiyo's Journal

At the beginning of your upkeep, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
{T}, Sacrifice three Clues: Search your library for a card, put that card into your hand, then shuffle.

Displaced Dinosaurs

As a historic permanent you control enters, it becomes a 7/7 Dinosaur creature in addition to its other types. (Artifacts, legendaries, and Sagas are historic.)

Morska, Undersea Sleuth

You have no maximum hand size.
At the beginning of your upkeep, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
Whenever you draw your second card each turn, put two +1/+1 counters on Morska, Undersea Sleuth.

Spara's Headquarters

({T}: Add {G}, {W}, or {U}.)
Spara's Headquarters enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Getting

In Too Deep

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Enchant creature, planeswalker, or Clue
Enchanted permanent is a colorless Clue artifact with "{2}, Sacrifice this artifact: Draw a card" and loses all other abilities. (It's no longer a creature or planeswalker.)

Alquist Proft, Master Sleuth

Vigilance
When Alquist Proft, Master Sleuth enters, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
{X}{W}{U}{U}, {T}, Sacrifice a Clue: You draw X cards and gain X life.

Urza, Lord High Artificer

When Urza, Lord High Artificer enters, create a 0/0 colorless Construct artifact creature token with "This creature gets +1/+1 for each artifact you control."
Tap an untapped artifact you control: Add {U}.
{5}: Shuffle your library, then exile the top card. Until end of turn, you may play that card without paying its mana cost.

Yotian Dissident

Whenever an artifact you control enters, put a +1/+1 counter on target creature you control.

The Pride of Hull Clade

This spell costs {X} less to cast, where X is the total toughness of creatures you control.
Defender
{2}{U}{U}: Until end of turn, target creature you control gets +1/+0, gains "Whenever this creature deals combat damage to a player, draw cards equal to its toughness," and can attack as though it didn't have defender.

Five Hundred Year Diary

Five Hundred Year Diary enters tapped.
{T}: Add {U} for each Clue you control.
{2}, Sacrifice Five Hundred Year Diary: Draw a card.

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Ezrim, Agency Chief

Flying
When Ezrim, Agency Chief enters, investigate twice. (To investigate, create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
{1}, Sacrifice an artifact: Ezrim gains your choice of vigilance, lifelink, or hexproof until end of turn.

Seedborn Muse

Untap all permanents you control during each other player's untap step.

The Third Doctor

Trample
The Third Doctor gets +1/+1 for each noncreature token you control.
When The Third Doctor enters, create your choice of a Clue token, a Food token, or a Treasure token.