Consuming Sepulcher

At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Tithing Blade

When Tithing Blade enters the battlefield, each opponent sacrifices a creature.
Craft with creature {4}{B} ({4}{B}, Exile this artifact, Exile a creature you control or a creature card from your graveyard: Return this card transformed under its owner's control. Craft only as a sorcery.)

Tithing Blade // Consuming Sepulcher

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Ghost Council of Orzhova

When Ghost Council of Orzhova enters the battlefield, target opponent loses 1 life and you gain 1 life.
{1}, Sacrifice a creature: Exile Ghost Council of Orzhova. Return it to the battlefield under its owner's control at the beginning of the next end step.

Nezumi Road Captain

Menace
Vehicles you control have menace. (They can't be blocked except by two or more creatures.)

Okiba Reckoner Raid

(As this Saga enters and after your draw step, add a lore counter.)
I, II — Each opponent loses 1 life and you gain 1 life.
III — Exile this Saga, then return it to the battlefield transformed under your control.

Okiba Reckoner Raid // Nezumi Road Captain

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Nightshade Harvester

Whenever a land enters the battlefield under an opponent's control, that player loses 1 life. Put a +1/+1 counter on Nightshade Harvester.

Ob Nixilis of the Black Oath

+2: Each opponent loses 1 life. You gain life equal to the life lost this way.
−2: Create a 5/5 black Demon creature token with flying. You lose 2 life.
−8: You get an emblem with "{1}{B}, Sacrifice a creature: You gain X life and draw X cards, where X is the sacrificed creature's power."
Ob Nixilis of the Black Oath can be your commander.

Agent of the Iron Throne

Commander creatures you own have "Whenever an artifact or creature you control is put into a graveyard from the battlefield, each opponent loses 1 life."

Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature enters the battlefield under your control, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Astarion, the Decadent

Deathtouch, lifelink
At the beginning of your end step, choose one —
• Feed — Target opponent loses life equal to the amount of life they lost this turn.
• Friends — You gain life equal to the amount of life you gained this turn.

Corpse Knight

Whenever another creature enters the battlefield under your control, each opponent loses 1 life.

Foul-Tongue Shriek

Target opponent loses 1 life for each attacking creature you control. You gain that much life.

Wispdrinker Vampire

Flying
Whenever another creature with power 2 or less enters the battlefield under your control, each opponent loses 1 life and you gain 1 life.
{5}{W}{B}: Creatures you control with power 2 or less gain deathtouch and lifelink until end of turn.

Trespasser's Curse

Enchant player
Whenever a creature enters the battlefield under enchanted player's control, that player loses 1 life and you gain 1 life.

Retreat to Hagra

Landfall — Whenever a land enters the battlefield under your control, choose one —
• Target creature gets +1/+0 and gains deathtouch until end of turn.
• Each opponent loses 1 life and you gain 1 life.

Cruel Celebrant

Whenever Cruel Celebrant or another creature or planeswalker you control dies, each opponent loses 1 life and you gain 1 life.

Elas il-Kor, Sadistic Pilgrim

Deathtouch
Whenever another creature enters the battlefield under your control, you gain 1 life.
Whenever another creature you control dies, each opponent loses 1 life.

Suffer the Past

Exile X target cards from target player's graveyard. For each card exiled this way, that player loses 1 life and you gain 1 life.

Sanctum Seeker

Whenever a Vampire you control attacks, each opponent loses 1 life and you gain 1 life.

Death Cultist

Sacrifice Death Cultist: Target player loses 1 life and you gain 1 life.

Wicked Visitor

Whenever an enchantment you control is put into a graveyard from the battlefield, each opponent loses 1 life.

Marauding Blight-Priest

Mardu Shadowspear

Whenever Mardu Shadowspear attacks, each opponent loses 1 life.
Dash {1}{B} (You may cast this spell for its dash cost. If you do, it gains haste, and it's returned from the battlefield to its owner's hand at the beginning of the next end step.)

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Plague Belcher

Menace
When Plague Belcher enters the battlefield, put two -1/-1 counters on target creature you control.
Whenever another Zombie you control dies, each opponent loses 1 life.

Mind Drain

Target opponent discards two cards, mills a card, and loses 1 life. You gain 1 life. (To mill a card, a player puts the top card of their library into their graveyard.)

The Meathook Massacre

When The Meathook Massacre enters the battlefield, each creature gets -X/-X until end of turn.
Whenever a creature you control dies, each opponent loses 1 life.
Whenever a creature an opponent controls dies, you gain 1 life.

Mirkwood Bats

Flying
Whenever you create or sacrifice a token, each opponent loses 1 life.

Wayward Servant

Whenever another Zombie enters the battlefield under your control, each opponent loses 1 life and you gain 1 life.

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Hierophant's Chalice

When Hierophant's Chalice enters the battlefield, target opponent loses 1 life and you gain 1 life.
{T}: Add {C}.

Hooded Blightfang

Deathtouch
Whenever a creature you control with deathtouch attacks, each opponent loses 1 life and you gain 1 life.
Whenever a creature you control with deathtouch deals damage to a planeswalker, destroy that planeswalker.

Relic Vial

{2}, {T}, Sacrifice a creature: Draw a card.
As long as you control a Cleric, Relic Vial has "Whenever a creature you control dies, each opponent loses 1 life and you gain 1 life."

Gruesome Fate

Each opponent loses 1 life for each creature you control.

Kalastria Healer

Rally — Whenever Kalastria Healer or another Ally enters the battlefield under your control, each opponent loses 1 life and you gain 1 life.

Maggot Carrier

When Maggot Carrier enters the battlefield, each player loses 1 life.

Mage Hunters' Onslaught

Destroy target creature or planeswalker.
Whenever a creature blocks this turn, its controller loses 1 life.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Leechridden Swamp

({T}: Add {B}.)
Leechridden Swamp enters the battlefield tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Bastion of Remembrance

When Bastion of Remembrance enters the battlefield, create a 1/1 white Human Soldier creature token.
Whenever a creature you control dies, each opponent loses 1 life and you gain 1 life.

Denethor, Ruling Steward

At the beginning of your end step, if a creature died under your control this turn, create a 1/1 white Human Soldier creature token.
{2}, Sacrifice another creature: Each opponent loses 1 life and you gain 1 life.

Campaign of Vengeance

Whenever a creature you control attacks, defending player loses 1 life and you gain 1 life.

Pulse Tracker

Whenever Pulse Tracker attacks, each opponent loses 1 life.

Liability

Whenever a nontoken permanent is put into a player's graveyard from the battlefield, that player loses 1 life.

Gibbering Descent

At the beginning of each player's upkeep, that player loses 1 life and discards a card.
Hellbent — Skip your upkeep step if you have no cards in hand.
Madness {2}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Disemvowel

Destroy target creature. That creature's controller loses 1 life for each unique vowel in the creature's name. (The vowels are A, E, I, O, U, and Y.)

One Ring to Rule Them All

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — The Ring tempts you, then each player mills cards equal to your Ring-bearer's power.
II — Destroy all nonlegendary creatures.
III — Each opponent loses 1 life for each creature card in that player's graveyard.

Vicious Conquistador

Whenever Vicious Conquistador attacks, each opponent loses 1 life.

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

One Thousand Lashes

Enchant creature
Enchanted creature can't attack or block, and its activated abilities can't be activated.
At the beginning of the upkeep of enchanted creature's controller, that player loses 1 life.

Nadier's Nightblade

Whenever a token you control leaves the battlefield, each opponent loses 1 life and you gain 1 life.

Duskwielder

Boast — {1}: Target opponent loses 1 life and you gain 1 life. (Activate only if this creature attacked this turn and only once each turn.)

Underworld Coinsmith

Constellation — Whenever Underworld Coinsmith or another enchantment enters the battlefield under your control, you gain 1 life.
{W}{B}, Pay 1 life: Each opponent loses 1 life.

God-Pharaoh's Statue

Spells your opponents cast cost {2} more to cast.
At the beginning of your end step, each opponent loses 1 life.

Garrulous Sycophant

At the beginning of your end step, if you're the monarch, each opponent loses 1 life and you gain 1 life.

Wernog, Rider's Chaplain

When Wernog, Rider's Chaplain enters or leaves the battlefield, each opponent may investigate. Each opponent who doesn't loses 1 life. You investigate X times, where X is one plus the number of opponents who investigated this way.
Friends forever (You can have two commanders if both have friends forever.)

Marchesa's Decree

When Marchesa's Decree enters the battlefield, you become the monarch.
Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.

Lampad of Death's Vigil

{1}, Sacrifice a creature: Each opponent loses 1 life and you gain 1 life.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature.

Gríma Wormtongue

Your opponents can't gain life.
{T}, Sacrifice another creature: Target player loses 1 life. If the sacrificed creature was legendary, amass Orcs 2.

Forerunner of the Coalition

When Forerunner of the Coalition enters the battlefield, you may search your library for a Pirate card, reveal it, then shuffle and put that card on top.
Whenever another Pirate enters the battlefield under your control, each opponent loses 1 life.

Soot Imp

Flying
Whenever a player casts a nonblack spell, that player loses 1 life.

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Hissing Miasma

Whenever a creature attacks you, its controller loses 1 life.

Curse of Wizardry

As Curse of Wizardry enters the battlefield, choose a color.
Whenever a player casts a spell of the chosen color, that player loses 1 life.

Grim Guardian

Constellation — Whenever Grim Guardian or another enchantment enters the battlefield under your control, each opponent loses 1 life.

Night Market Lookout

Whenever Night Market Lookout becomes tapped, each opponent loses 1 life and you gain 1 life.

Subversion

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.