Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control, then sacrifices a third of the lands they control. Round up each time.

Runehorn Hellkite

Flying
{5}{R}, Exile Runehorn Hellkite from your graveyard: Each player discards their hand, then draws seven cards.

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Skull Rend

Skull Rend deals 2 damage to each opponent. Those players each discard two cards at random.

Avatar of Woe

If there are ten or more creature cards total in all graveyards, this spell costs {6} less to cast.
Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
{T}: Destroy target creature. It can't be regenerated.

Burning Earth

Whenever a player taps a nonbasic land for mana, Burning Earth deals 1 damage to that player.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

Mogis, God of Slaughter

Indestructible
As long as your devotion to black and red is less than seven, Mogis isn't a creature.
At the beginning of each opponent's upkeep, Mogis deals 2 damage to that player unless they sacrifice a creature.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis, Unshackled.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Manabarbs

Whenever a player taps a land for mana, Manabarbs deals 1 damage to that player.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Star of Extinction

Destroy target land. Star of Extinction deals 20 damage to each creature and each planeswalker.

Gibbering Descent

At the beginning of each player's upkeep, that player loses 1 life and discards a card.
Hellbent — Skip your upkeep step if you have no cards in hand.
Madness {2}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Liliana of the Dark Realms

+1: Search your library for a Swamp card, reveal it, put it into your hand, then shuffle.
−3: Target creature gets +X/+X or -X/-X until end of turn, where X is the number of Swamps you control.
−6: You get an emblem with "Swamps you control have '{T}: Add {B}{B}{B}{B}.'"

Geier Reach Sanitarium

{T}: Add {C}.
{2}, {T}: Each player draws a card, then discards a card.

Finale of Promise

You may cast up to one target instant card and/or up to one target sorcery card from your graveyard each with mana value X or less without paying their mana costs. If a spell cast this way would be put into your graveyard, exile it instead. If X is 10 or more, copy each of those spells twice. You may choose new targets for the copies.

Burning Inquiry

Each player draws three cards, then discards three cards at random.

Terminate

Destroy target creature. It can't be regenerated.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Spellshock

Whenever a player casts a spell, Spellshock deals 2 damage to that player.

Delirium Skeins

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Hypnotic Specter

Flying
Whenever Hypnotic Specter deals damage to an opponent, that player discards a card at random.

Skullcage

At the beginning of each opponent's upkeep, Skullcage deals 2 damage to that player unless they have exactly three or exactly four cards in hand.

Dragon Mage

Flying
Whenever Dragon Mage deals combat damage to a player, each player discards their hand, then draws seven cards.

Pain Magnification

Whenever an opponent is dealt 3 or more damage by a single source, that player discards a card.

Tsabo Tavoc

First strike, protection from legendary creatures
{B}{B}, {T}: Destroy target legendary creature. It can't be regenerated.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Rix Maadi, Dungeon Palace

{T}: Add {C}.
{1}{B}{R}, {T}: Each player discards a card. Activate only as a sorcery.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Polluted Bonds

Whenever a land enters the battlefield under an opponent's control, that player loses 2 life and you gain 2 life.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Reforge the Soul

Each player discards their hand, then draws seven cards.
Miracle {1}{R} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Wrecking Ball

Magus of the Wheel

{1}{R}, {T}, Sacrifice Magus of the Wheel: Each player discards their hand, then draws seven cards.

Cunning Lethemancer

At the beginning of your upkeep, each player discards a card.

Shrieking Affliction

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 3 life.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Fell Specter

Flying
When Fell Specter enters the battlefield, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Victimize

Choose two target creature cards in your graveyard. Sacrifice a creature. If you do, return the chosen cards to the battlefield tapped.

Phyrexian Purge

This spell costs 3 life more to cast for each target.
Destroy any number of target creatures.

Bontu's Last Reckoning

Destroy all creatures. Lands you control don't untap during your next untap step.

Agonizing Demise

Kicker {1}{R} (You may pay an additional {1}{R} as you cast this spell.)
Destroy target nonblack creature. It can't be regenerated. If this spell was kicked, Agonizing Demise deals damage equal to that creature's power to the creature's controller.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature, then sacrifices a land.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Rakdos Charm

Choose one —
• Exile target player's graveyard.
• Destroy target artifact.
• Each creature deals 1 damage to its controller.

Bedevil

Destroy target artifact, creature, or planeswalker.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature.

Sire of Insanity

At the beginning of each end step, each player discards their hand.

Abrade

Choose one —
• Abrade deals 3 damage to target creature.
• Destroy target artifact.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Dreadbore

Suffering

Pain

Pain // Suffering

Neheb, the Worthy

First strike
Other Minotaurs you control have first strike.
As long as you have one or fewer cards in hand, Minotaurs you control get +2/+0.
Whenever Neheb, the Worthy deals combat damage to a player, each player discards a card.

Oppression

Whenever a player casts a spell, that player discards a card.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Mindslicer

When Mindslicer dies, each player discards their hand.

Angrath's Rampage

Choose one —
• Target player sacrifices an artifact.
• Target player sacrifices a creature.
• Target player sacrifices a planeswalker.

Chandra, Torch of Defiance

+1: Exile the top card of your library. You may cast that card. If you don't, Chandra, Torch of Defiance deals 2 damage to each opponent.
+1: Add {R}{R}.
−3: Chandra, Torch of Defiance deals 4 damage to target creature.
−7: You get an emblem with "Whenever you cast a spell, this emblem deals 5 damage to any target."