Niv-Mizzet, Supreme

Flying, hexproof from monocolored
Each instant and sorcery card in your graveyard that's exactly two colors has jump-start. (You may cast that card from your graveyard by discarding a card in addition to paying its other costs. Then exile it.)

Jenson Carthalion, Druid Exile

Whenever you cast a multicolored spell, scry 1. If that spell was all colors, create a 4/4 white Angel creature token with flying and vigilance.
{5}, {T}: Add {W}{U}{B}{R}{G}.

Soulherder

Whenever a creature is exiled from the battlefield, put a +1/+1 counter on Soulherder.
At the beginning of your end step, you may exile another target creature you control, then return that card to the battlefield under its owner's control.

Growth Spiral

Draw a card. You may put a land card from your hand onto the battlefield.

Time Wipe

Return a creature you control to its owner's hand, then destroy all creatures.

General Ferrous Rokiric

Hexproof from monocolored
Whenever you cast a multicolored spell, create a 4/4 red and white Golem artifact creature token.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Aurelia, the Warleader

Flying, vigilance, haste
Whenever Aurelia attacks for the first time each turn, untap all creatures you control. After this phase, there is an additional combat phase.

Aragorn, the Uniter

Whenever you cast a white spell, create a 1/1 white Human Soldier creature token.
Whenever you cast a blue spell, scry 2.
Whenever you cast a red spell, Aragorn, the Uniter deals 3 damage to target opponent.
Whenever you cast a green spell, target creature gets +4/+4 until end of turn.

Guildpact Paragon

Whenever you cast a spell that's exactly two colors, look at the top six cards of your library. You may reveal a card that's exactly two colors from among them and put it into your hand. Put the rest on the bottom of your library in a random order.

Invasion of Ravnica

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Ravnica enters, exile target nonland permanent an opponent controls that isn't exactly two colors.

Invasion of Ravnica // Guildpact Paragon

Dovin's Veto

This spell can't be countered.
Counter target noncreature spell.

Faeburrow Elder

Vigilance
Faeburrow Elder gets +1/+1 for each color among permanents you control.
{T}: For each color among permanents you control, add one mana of that color.

Assassin's Trophy

Destroy target permanent an opponent controls. Its controller may search their library for a basic land card, put it onto the battlefield, then shuffle.

Boros Charm

Choose one —
• Boros Charm deals 4 damage to target player or planeswalker.
• Permanents you control gain indestructible until end of turn.
• Target creature gains double strike until end of turn.

Niv-Mizzet Reborn

Flying
When Niv-Mizzet Reborn enters, reveal the top ten cards of your library. For each color pair, choose a card that's exactly those colors from among them. Put the chosen cards into your hand and the rest on the bottom of your library in a random order.

Pippin, Guard of the Citadel

Vigilance, ward {1}
{T}: Another target creature you control gains protection from the card type of your choice until end of turn. (It can't be blocked, targeted, dealt damage, enchanted, or equipped by anything of that type.)

Trostani, Three Whispers

{1}{G}: Target creature gains deathtouch until end of turn.
{G/W}: Target creature gains vigilance until end of turn.
{2}{W}: Target creature gains double strike until end of turn.

Knight of Autumn

When Knight of Autumn enters, choose one —
• Put two +1/+1 counters on Knight of Autumn.
• Destroy target artifact or enchantment.
• You gain 4 life.

Rakdos Charm

Choose one —
• Exile target player's graveyard.
• Destroy target artifact.
• Each creature deals 1 damage to its controller.

Knight of New Alara

Each other multicolored creature you control gets +1/+1 for each of its colors.

Rakdos, Patron of Chaos

Flying, trample
At the beginning of your end step, target opponent may sacrifice two nonland, nontoken permanents of their choice. If they don't, you draw two cards.

Dragon Arch

{2}, {T}: You may put a multicolored creature card from your hand onto the battlefield.

Uro, Titan of Nature's Wrath

When Uro enters, sacrifice it unless it escaped.
Whenever Uro enters or attacks, you gain 3 life and draw a card, then you may put a land card from your hand onto the battlefield.
Escape—{G}{G}{U}{U}, Exile five other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)

Saheeli, the Sun's Brilliance

{U}{R}, {T}: Create a token that's a copy of another target creature or artifact you control, except it's an artifact in addition to its other types. It gains haste. Sacrifice it at the beginning of the next end step.

Terminate

Destroy target creature. It can't be regenerated.

Kutzil, Malamet Exemplar

Your opponents can't cast spells during your turn.
Whenever one or more creatures you control each with power greater than its base power deals combat damage to a player, draw a card.

Baleful Strix

Flying, deathtouch
When Baleful Strix enters, draw a card.

Coiling Oracle

When Coiling Oracle enters, reveal the top card of your library. If it's a land card, put it onto the battlefield. Otherwise, put that card into your hand.

Niv-Mizzet, Guildpact

Flying, hexproof from multicolored
Whenever Niv-Mizzet, Guildpact deals combat damage to a player, it deals X damage to any target, target player draws X cards, and you gain X life, where X is the number of different color pairs among permanents you control that are exactly two colors.