Isolation Zone

When Isolation Zone enters, exile target creature or enchantment an opponent controls until Isolation Zone leaves the battlefield. (That permanent returns under its owner's control.)

Eternal Isolation

Put target creature with power 4 or greater on the bottom of its owner's library.

Temporal Isolation

Flash
Enchant creature
Enchanted creature has shadow. (It can block or be blocked by only creatures with shadow.)
Prevent all damage that would be dealt by enchanted creature.

Solitude

Flash
Lifelink
When Solitude enters, exile up to one other target creature. That creature's controller gains life equal to its power.
Evoke—Exile a white card from your hand.

Solitary Confinement

At the beginning of your upkeep, sacrifice Solitary Confinement unless you discard a card.
Skip your draw step.
You have shroud. (You can't be the target of spells or abilities.)
Prevent all damage that would be dealt to you.

Isolated Watchtower

{T}: Add {C}.
{2}, {T}: Scry 1, then you may reveal the top card of your library. If a basic land card is revealed this way, put it onto the battlefield tapped. Activate only if an opponent controls at least two more lands than you.

Solitary Sanctuary

When Solitary Sanctuary enters, tap target creature an opponent controls and put a stun counter on it. (If a permanent with a stun counter would become untapped, remove one from it instead.)
Whenever you tap an untapped creature an opponent controls, put a +1/+1 counter on target creature you control.

Fear of Isolation

As an additional cost to cast this spell, return a permanent you control to its owner's hand.
Flying

Isolation at Orthanc

Put target creature into its owner's library second from the top.

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.