Damnation

Destroy all creatures. They can't be regenerated.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Nirkana Revenant

Whenever you tap a Swamp for mana, add an additional {B}.
{B}: Nirkana Revenant gets +1/+1 until end of turn.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Dauthi Voidwalker

Shadow (This creature can block or be blocked by only creatures with shadow.)
If a card would be put into an opponent's graveyard from anywhere, instead exile it with a void counter on it.
{T}, Sacrifice Dauthi Voidwalker: Choose an exiled card an opponent owns with a void counter on it. You may play it this turn without paying its mana cost.

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When Gixian Puppeteer dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Creeping Bloodsucker

At the beginning of your upkeep, Creeping Bloodsucker deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Howling Golem

Whenever Howling Golem attacks or blocks, each player draws a card.

Horn of Greed

Whenever a player plays a land, that player draws a card.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Damnable Pact

Target player draws X cards and loses X life.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Blood Pact

Target player draws two cards and loses 2 life.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Sign in Blood

Throne of Eldraine

As Throne of Eldraine enters, choose a color.
{T}: Add four mana of the chosen color. Spend this mana only to cast monocolored spells of that color.
{3}, {T}: Draw two cards. Spend only mana of the chosen color to activate this ability.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Temple Bell

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Swamp

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Howling Mine

At the beginning of each player's draw step, if Howling Mine is untapped, that player draws an additional card.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature and you return up to one target creature card from your graveyard to your hand.

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Elixir of Immortality

{2}, {T}: You gain 5 life. Shuffle Elixir of Immortality and your graveyard into their owner's library.

Vampire Nighthawk

Font of Mythos

At the beginning of each player's draw step, that player draws two additional cards.

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Marauding Blight-Priest

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Zenith Chronicler

Whenever a player casts their first multicolored spell each turn, each other player draws a card.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Clockwork Fox

When Clockwork Fox leaves the battlefield, you draw two cards and each opponent draws a card.

Decanter of Endless Water

You have no maximum hand size.
{T}: Add one mana of any color.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Otherworld Atlas

{T}: Put a charge counter on Otherworld Atlas.
{T}: Each player draws a card for each charge counter on Otherworld Atlas.

Thought Vessel

Infernal Grasp

Destroy target creature. You lose 2 life.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Venser's Journal

You have no maximum hand size.
At the beginning of your upkeep, you gain 1 life for each card in your hand.

Sol Ring

Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Whip of Erebos

Creatures you control have lifelink.
{2}{B}{B}, {T}: Return target creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step. If it would leave the battlefield, exile it instead of putting it anywhere else. Activate only as a sorcery.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Veinwitch Coven

Menace
Whenever you gain life, you may pay {B}. If you do, return target creature card from your graveyard to your hand.