Invoke Despair

Target opponent sacrifices a creature of their choice. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Daggerdrome Imp

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Vampire's Kiss

Target player loses 2 life and you gain 2 life. Create two Blood tokens. (They're artifacts with "{1}, {T}, Discard a card, Sacrifice this token: Draw a card.")

Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

Subterranean Hangar

This land enters tapped.
{T}: Put a storage counter on this land.
{T}, Remove any number of storage counters from this land: Add {B} for each storage counter removed this way.

Ill-Gotten Inheritance

At the beginning of your upkeep, this enchantment deals 1 damage to each opponent and you gain 1 life.
{5}{B}, Sacrifice this enchantment: It deals 4 damage to target opponent and you gain 4 life.

Gruesome Deformity

Enchant creature
Enchanted creature has intimidate. (It can't be blocked except by artifact creatures and/or creatures that share a color with it.)

Sorin the Mirthless

+1: Look at the top card of your library. You may reveal that card and put it into your hand. If you do, you lose life equal to its mana value.
−2: Create a 2/3 black Vampire creature token with flying and lifelink.
−7: Sorin deals 13 damage to any target. You gain 13 life.

Underworld Dreams

Whenever an opponent draws a card, this enchantment deals 1 damage to that player.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Caged Sun

As this artifact enters, choose a color.
Creatures you control of the chosen color get +1/+1.
Whenever a land's ability causes you to add one or more mana of the chosen color, add an additional one mana of that color.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Asmodeus the Archfiend

Binding Contract — If you would draw a card, exile the top card of your library face down instead.
{B}{B}{B}: Draw seven cards.
{B}: Return all cards exiled with Asmodeus to their owner's hand and you lose that much life.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Hellish Rebuke

Until end of turn, permanents your opponents control gain "When this permanent deals damage to the player who cast Hellish Rebuke, sacrifice this permanent. You lose 2 life."

Battlefield Butcher

{5}, {T}: Each opponent loses 2 life. This ability costs {1} less to activate for each creature card in your graveyard.

Essence Harvest

Target player loses X life and you gain X life, where X is the greatest power among creatures you control.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Infectious Horror

Whenever this creature attacks, each opponent loses 2 life.

Aspect of Lamprey

Enchant creature you control
When this Aura enters, target opponent discards two cards.
Enchanted creature has lifelink.

Swamp

Liliana of the Dark Realms

+1: Search your library for a Swamp card, reveal it, put it into your hand, then shuffle.
−3: Target creature gets +X/+X or -X/-X until end of turn, where X is the number of Swamps you control.
−6: You get an emblem with "Swamps you control have '{T}: Add {B}{B}{B}{B}.'"

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Zof Bloodbog

Zof Consumption

Each opponent loses 4 life and you gain 4 life.

Zof Consumption // Zof Bloodbog

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature of their choice and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis.

The Book of Vile Darkness

At the beginning of your end step, if you lost 2 or more life this turn, create a 2/2 black Zombie creature token.
{T}, Exile The Book of Vile Darkness and artifacts you control named Eye of Vecna and Hand of Vecna: Create Vecna, a legendary 8/8 black Zombie God creature token with indestructible and all triggered abilities of the exiled cards.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Blitzwing, Adaptive Assailant

Living metal (During your turn, this Vehicle is also a creature.)
At the beginning of combat on your turn, choose flying or indestructible at random. Blitzwing gains that ability until end of turn.
Whenever Blitzwing deals combat damage to a player, convert it.

Blitzwing, Cruel Tormentor

More Than Meets the Eye {3}{B} (You may cast this card converted for {3}{B}.)
At the beginning of your end step, target opponent loses life equal to the life that player lost this turn. If no life is lost this way, convert Blitzwing.

Blitzwing, Cruel Tormentor // Blitzwing, Adaptive Assailant

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Takenuma, Abandoned Mire

{T}: Add {B}.
Channel — {3}{B}, Discard this card: Mill three cards, then return a creature or planeswalker card from your graveyard to your hand. This ability costs {1} less to activate for each legendary creature you control.

Polluted Mire

This land enters tapped.
{T}: Add {B}.
Cycling {2} ({2}, Discard this card: Draw a card.)

Erebos's Intervention

Choose one —
• Target creature gets -X/-X until end of turn. You gain X life.
• Exile up to twice X target cards from graveyards.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Bloodhunter Bat

Flying
When this creature enters, target player loses 2 life and you gain 2 life.

Falthis, Shadowcat Familiar

Commanders you control have menace and deathtouch.
Partner (You can have two commanders if both have partner.)

Sovereign's Bite

Target player loses 3 life and you gain 3 life.

Fate Unraveler

Whenever an opponent draws a card, this creature deals 1 damage to that player.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Herald of Hadar

Circle of Death — {5}{B}: Roll a d20.
1—9 | Each opponent loses 2 life.
10—19 | Each opponent loses 2 life and you gain 2 life.
20 | Each opponent loses 2 life and you gain 2 life. Create two Treasure tokens. (They're artifacts with "{T}, Sacrifice this token: Add one mana of any color.")

Blood Artist

Whenever this creature or another creature dies, target player loses 1 life and you gain 1 life.

Enslave

Enchant creature
You control enchanted creature.
At the beginning of your upkeep, enchanted creature deals 1 damage to its owner.

Professor Onyx

Magecraft — Whenever you cast or copy an instant or sorcery spell, each opponent loses 2 life and you gain 2 life.
+1: You lose 1 life. Look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
−3: Each opponent sacrifices a creature with the greatest power among creatures that player controls.
−8: Each opponent may discard a card. If they don't, they lose 3 life. Repeat this process six more times.

Sedgemoor Witch

Menace
Ward—Pay 3 life. (Whenever this creature becomes the target of a spell or ability an opponent controls, counter it unless that player pays 3 life.)
Magecraft — Whenever you cast or copy an instant or sorcery spell, create a 1/1 black and green Pest creature token with "When this token dies, you gain 1 life."

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Shadows' Lair

(Transforms from Grasping Shadows.)
{T}: Add {B}.
{B}, {T}, Remove a dread counter from this land: You draw a card and you lose 1 life.

Grasping Shadows

Whenever a creature you control attacks alone, it gains deathtouch and lifelink until end of turn. Put a dread counter on this enchantment. Then if there are three or more dread counters on it, transform it.

Grasping Shadows // Shadows' Lair

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Creeping Bloodsucker

At the beginning of your upkeep, this creature deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Nashi, Moon Sage's Scion

Ninjutsu {3}{B} ({3}{B}, Return an unblocked attacker you control to hand: Put this card onto the battlefield from your hand tapped and attacking.)
Whenever Nashi deals combat damage to a player, exile the top card of each player's library. Until end of turn, you may play one of those cards. If you cast a spell this way, pay life equal to its mana value rather than paying its mana cost.

Corrupt

Corrupt deals damage to any target equal to the number of Swamps you control. You gain life equal to the damage dealt this way.

Soulcage Fiend

When this creature dies, each player loses 3 life.

Ayara, First of Locthwain

Whenever Ayara or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Court of Ambition

When this enchantment enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Bojuka Bog

This land enters tapped.
When this land enters, exile target player's graveyard.
{T}: Add {B}.

Wall of Limbs

Defender (This creature can't attack.)
Whenever you gain life, put a +1/+1 counter on this creature.
{5}{B}{B}, Sacrifice this creature: Target player loses X life, where X is this creature's power.

Razorlash Transmogrant

This creature can't block.
{4}{B}{B}: Return this card from your graveyard to the battlefield with a +1/+1 counter on it. This ability costs {4} less to activate if an opponent controls four or more nonbasic lands.

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Ragged Veins

Flash
Enchant creature
Whenever enchanted creature is dealt damage, its controller loses that much life.

Indulgent Tormentor

Flying
At the beginning of your upkeep, draw a card unless target opponent sacrifices a creature of their choice or pays 3 life.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Gray Merchant of Asphodel

When this creature enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Biting-Palm Ninja

Ninjutsu {2}{B}
This creature enters with a menace counter on it.
Whenever this creature deals combat damage to a player, you may remove a menace counter from it. When you do, that player reveals their hand and you choose a nonland card from it. Exile that card.