Engineered Plague

As Engineered Plague enters the battlefield, choose a creature type.
All creatures of the chosen type get -1/-1.

Carnifex Demon

Flying
Carnifex Demon enters the battlefield with two -1/-1 counters on it.
{B}, Remove a -1/-1 counter from Carnifex Demon: Put a -1/-1 counter on each other creature.

Ascendant Evincar

Flying (This creature can't be blocked except by creatures with flying or reach.)
Other black creatures get +1/+1.
Nonblack creatures get -1/-1.

Caustic Crawler

Landfall — Whenever a land enters the battlefield under your control, you may have target creature get -1/-1 until end of turn.

Archfiend of Ifnir

Flying
Whenever you cycle or discard another card, put a -1/-1 counter on each creature your opponents control.
Cycling {2} ({2}, Discard this card: Draw a card.)

Etched Monstrosity

Etched Monstrosity enters the battlefield with five -1/-1 counters on it.
{W}{U}{B}{R}{G}, Remove five -1/-1 counters from Etched Monstrosity: Target player draws three cards.

Crovax, Ascendant Hero

Other white creatures get +1/+1.
Nonwhite creatures get -1/-1.
Pay 2 life: Return Crovax, Ascendant Hero to its owner's hand.

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Borrowed Malevolence

Escalate {2} (Pay this cost for each mode chosen beyond the first.)
Choose one or both —
• Target creature gets +1/+1 until end of turn.
• Target creature gets -1/-1 until end of turn.

Death's-Head Buzzard

Flying
When Death's-Head Buzzard dies, all creatures get -1/-1 until end of turn.

Channeler Initiate

When Channeler Initiate enters the battlefield, put three -1/-1 counters on target creature you control.
{T}, Remove a -1/-1 counter from Channeler Initiate: Add one mana of any color.

Dread of Night

Curse of Death's Hold

Enchant player
Creatures enchanted player controls get -1/-1.

Benalish Cavalry

Flanking (Whenever a creature without flanking blocks this creature, the blocking creature gets -1/-1 until end of turn.)

Ethereal Absolution

Creatures you control get +1/+1.
Creatures your opponents control get -1/-1.
{2}{W}{B}: Exile target card from an opponent's graveyard. If it was a creature card, you create a 1/1 white and black Spirit creature token with flying.

Crumbling Ashes

At the beginning of your upkeep, destroy target creature with a -1/-1 counter on it.

Corrosive Mentor

Black creatures you control have wither. (They deal damage to creatures in the form of -1/-1 counters.)

Doomwake Giant

Constellation — Whenever Doomwake Giant or another enchantment enters the battlefield under your control, creatures your opponents control get -1/-1 until end of turn.

Black Sun's Zenith

Put X -1/-1 counters on each creature. Shuffle Black Sun's Zenith into its owner's library.

Contagion Clasp

When Contagion Clasp enters the battlefield, put a -1/-1 counter on target creature.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Cower in Fear

Creatures your opponents control get -1/-1 until end of turn.

Cauldron Haze

Choose any number of target creatures. Each of those creatures gains persist until end of turn. (When it dies, if it had no -1/-1 counters on it, return it to the battlefield under its owner's control with a -1/-1 counter on it.)

Deathspore Thallid

At the beginning of your upkeep, put a spore counter on Deathspore Thallid.
Remove three spore counters from Deathspore Thallid: Create a 1/1 green Saproling creature token.
Sacrifice a Saproling: Target creature gets -1/-1 until end of turn.

Cadaverous Knight

Flanking (Whenever a creature without flanking blocks this creature, the blocking creature gets -1/-1 until end of turn.)
{1}{B}{B}: Regenerate Cadaverous Knight.

Blister Beetle

When Blister Beetle enters the battlefield, target creature gets -1/-1 until end of turn.

Crippling Blight

Enchant creature
Enchanted creature gets -1/-1 and can't block.

Dreamspoiler Witches

Flying
Whenever you cast a spell during an opponent's turn, you may have target creature get -1/-1 until end of turn.

Consumptive Goo

{2}{B}{B}: Target creature gets -1/-1 until end of turn. Put a +1/+1 counter on Consumptive Goo.

Contagion Engine

When Contagion Engine enters the battlefield, put a -1/-1 counter on each creature target player controls.
{4}, {T}: Proliferate twice. (Choose any number of permanents and/or players, then give each another counter of each kind already there. Then do it again.)

Cauldron of Souls

{T}: Choose any number of target creatures. Each of those creatures gains persist until end of turn. (When it dies, if it had no -1/-1 counters on it, return it to the battlefield under its owner's control with a -1/-1 counter on it.)

Blowfly Infestation

Whenever a creature dies, if it had a -1/-1 counter on it, put a -1/-1 counter on target creature.