Leyline of Sanctity

If this card is in your opening hand, you may begin the game with it on the battlefield.
You have hexproof. (You can't be the target of spells or abilities your opponents control.)

Serum Powder

{T}: Add {C}.
Any time you could mulligan and this card is in your hand, you may exile all the cards from your hand, then draw that many cards. (You can do this in addition to taking mulligans.)

Leyline of the Meek

If this card is in your opening hand, you may begin the game with it on the battlefield.
Creature tokens get +1/+1.

Leyline of Lightning

If this card is in your opening hand, you may begin the game with it on the battlefield.
Whenever you cast a spell, you may pay {1}. If you do, this enchantment deals 1 damage to target player or planeswalker.

Panglacial Wurm

Trample
While you're searching your library, you may cast this card from your library.

Leyline of Lifeforce

If this card is in your opening hand, you may begin the game with it on the battlefield.
Creature spells can't be countered.

Leyline of Singularity

If this card is in your opening hand, you may begin the game with it on the battlefield.
All nonland permanents are legendary.

Leyline of Anticipation

If this card is in your opening hand, you may begin the game with it on the battlefield.
You may cast spells as though they had flash.

Leyline of Abundance

If this card is in your opening hand, you may begin the game with it on the battlefield.
Whenever you tap a creature for mana, add an additional {G}.
{6}{G}{G}: Put a +1/+1 counter on each creature you control.

Progenitus

Protection from everything
If Progenitus would be put into a graveyard from anywhere, reveal Progenitus and shuffle it into its owner's library instead.

Leyline of Combustion

If this card is in your opening hand, you may begin the game with it on the battlefield.
Whenever you and/or at least one permanent you control becomes the target of a spell or ability an opponent controls, this enchantment deals 2 damage to that player.

Leyline of Vitality

If this card is in your opening hand, you may begin the game with it on the battlefield.
Creatures you control get +0/+1.
Whenever a creature you control enters, you may gain 1 life.

Leyline of Punishment

If this card is in your opening hand, you may begin the game with it on the battlefield.
Players can't gain life.
Damage can't be prevented.

Leyline of the Void

If this card is in your opening hand, you may begin the game with it on the battlefield.
If a card would be put into an opponent's graveyard from anywhere, exile it instead.