Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Feral Ghoul

Menace
Whenever another creature you control dies, put a +1/+1 counter on Feral Ghoul.
When Feral Ghoul dies, each opponent gets a number of rad counters equal to its power.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Necrogoyf

Necrogoyf's power is equal to the number of creature cards in all graveyards.
At the beginning of each player's upkeep, that player discards a card.
Madness {1}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Throne of Eldraine

As Throne of Eldraine enters, choose a color.
{T}: Add four mana of the chosen color. Spend this mana only to cast monocolored spells of that color.
{3}, {T}: Draw two cards. Spend only mana of the chosen color to activate this ability.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Plaguecrafter

When Plaguecrafter enters, each player sacrifices a creature or planeswalker. Each player who can't discards a card.

Nezumi Informant

When Nezumi Informant enters, each opponent discards a card.

Cunning Lethemancer

At the beginning of your upkeep, each player discards a card.

Delirium Skeins

Mind Rake

Target player discards two cards.
Overload {1}{B} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Elderfang Disciple

When Elderfang Disciple enters, each opponent discards a card.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Stronghold Rats

Shadow (This creature can block or be blocked by only creatures with shadow.)
Whenever Stronghold Rats deals combat damage to a player, each player discards a card.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Fell Specter

Flying
When Fell Specter enters, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Liliana's Specter

Flying
When Liliana's Specter enters, each opponent discards a card.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Doomsday Confluence

Choose X. You may choose the same mode more than once.
• Each player sacrifices a nonartifact creature.
• Create a 3/3 black Dalek artifact creature token with menace.
• Each opponent discards a card.

Virus Beetle

When Virus Beetle enters, each opponent discards a card.

The Raven Man

At the beginning of each end step, if a player discarded a card this turn, create a 1/1 black Bird creature token with flying and "This creature can't block."
{3}{B}, {T}: Each opponent discards a card. Activate only as a sorcery.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters, if it was kicked, target opponent discards two cards at random.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Infernal Grasp

Destroy target creature. You lose 2 life.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Hopeless Nightmare

When Hopeless Nightmare enters, each opponent discards a card and loses 2 life.
When Hopeless Nightmare is put into a graveyard from the battlefield, scry 2.
{2}{B}: Sacrifice Hopeless Nightmare.

Sign in Blood

Target player draws two cards and loses 2 life.

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Burglar Rat

When Burglar Rat enters, each opponent discards a card.

Oppression

Whenever a player casts a spell, that player discards a card.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.