Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Hedron Archive

{T}: Add {C}{C}.
{2}, {T}, Sacrifice Hedron Archive: Draw two cards.

Carrion Howler

Pay 1 life: Carrion Howler gets +2/-1 until end of turn.

Orzhov Keyrune

{T}: Add {W} or {B}.
{W}{B}: Orzhov Keyrune becomes a 1/4 white and black Thrull artifact creature with lifelink until end of turn.

Replicating Ring

{T}: Add one mana of any color.
At the beginning of your upkeep, put a night counter on Replicating Ring. Then if it has eight or more night counters on it, remove all of them and create eight colorless snow artifact tokens named Replicated Ring with "{T}: Add one mana of any color."

Everflowing Chalice

Multikicker {2} (You may pay an additional {2} any number of times as you cast this spell.)
Everflowing Chalice enters the battlefield with a charge counter on it for each time it was kicked.
{T}: Add {C} for each charge counter on Everflowing Chalice.

Charcoal Diamond

Charcoal Diamond enters the battlefield tapped.
{T}: Add {B}.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Soul of Eternity

Soul of Eternity's power and toughness are each equal to your life total.
Encore {7}{W}{W} ({7}{W}{W}, Exile this card from your graveyard: For each opponent, create a token copy that attacks that opponent this turn if able. They gain haste. Sacrifice them at the beginning of the next end step. Activate only as a sorcery.)

Temple of Silence

Temple of Silence enters the battlefield tapped.
When Temple of Silence enters the battlefield, scry 1.
{T}: Add {W} or {B}.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters the battlefield, each player loses a third of their life, rounded up.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Orzhov Cluestone

{T}: Add {W} or {B}.
{W}{B}, {T}, Sacrifice Orzhov Cluestone: Draw a card.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Pontiff of Blight

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Other creatures you control have extort. (If a creature has multiple instances of extort, each triggers separately.)

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature and you return up to one target creature card from your graveyard to your hand.

Storm Herd

Create X 1/1 white Pegasus creature tokens with flying, where X is your life total.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters the battlefield, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Serra Avatar

Serra Avatar's power and toughness are each equal to your life total.
When Serra Avatar is put into a graveyard from anywhere, shuffle it into its owner's library.

Markov Purifier

Lifelink
At the beginning of your end step, if you gained life this turn, you may pay {2}. If you do, draw a card.

Sigarda's Splendor

As Sigarda's Splendor enters the battlefield, note your life total.
At the beginning of your upkeep, draw a card if your life total is greater than or equal to the last noted life total for Sigarda's Splendor. Then note your life total.
Whenever you cast a white spell, you gain 1 life.

Arbiter of Knollridge

Vigilance
When Arbiter of Knollridge enters the battlefield, each player's life total becomes the highest life total among all players.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Mortify

Life Insurance

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever a nontoken creature dies, you lose 1 life and create a Treasure token.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Stonespeaker Crystal

{T}: Add {C}{C}.
{2}, {T}, Sacrifice Stonespeaker Crystal: Exile any number of target players' graveyards. Draw a card.

Blood Tribute

Kicker—Tap an untapped Vampire you control. (You may tap a Vampire you control in addition to any other costs as you cast this spell.)
Target opponent loses half their life, rounded up. If this spell was kicked, you gain life equal to the life lost this way.

Nykthos Paragon

Whenever you gain life, you may put that many +1/+1 counters on each creature you control. Do this only once each turn.

Pristine Talisman

Greed

Orzhov Signet

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Speaker of the Heavens

Vigilance, lifelink
{T}: Create a 4/4 white Angel creature token with flying. Activate only if you have at least 7 life more than your starting life total and only as a sorcery.

Suture Priest

Whenever another creature enters the battlefield under your control, you may gain 1 life.
Whenever a creature enters the battlefield under an opponent's control, you may have that player lose 1 life.

Orzhov Basilica

Orzhov Basilica enters the battlefield tapped.
When Orzhov Basilica enters the battlefield, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Dark Ritual

Deepwood Ghoul

Indulging Patrician

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your end step, if you gained 3 or more life this turn, each opponent loses 3 life.

Plains

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Sunscorch Regent and you gain 1 life.

Scoured Barrens

Scoured Barrens enters the battlefield tapped.
When Scoured Barrens enters the battlefield, you gain 1 life.
{T}: Add {W} or {B}.

Radiant Fountain

When Radiant Fountain enters the battlefield, you gain 2 life.
{T}: Add {C}.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Erebos's Intervention

Choose one —
• Target creature gets -X/-X until end of turn. You gain X life.
• Exile up to twice X target cards from graveyards.

Tainted Sigil

{T}, Sacrifice Tainted Sigil: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Shambling Vent

Shambling Vent enters the battlefield tapped.
{T}: Add {W} or {B}.
{1}{W}{B}: Shambling Vent becomes a 2/3 white and black Elemental creature with lifelink until end of turn. It's still a land.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Path of Ancestry

Path of Ancestry enters the battlefield tapped.
{T}: Add one mana of any color in your commander's color identity. When that mana is spent to cast a creature spell that shares a creature type with your commander, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Obscura Storefront

When Obscura Storefront enters the battlefield, sacrifice it. When you do, search your library for a basic Plains, Island, or Swamp card, put it onto the battlefield tapped, then shuffle and you gain 1 life.

Fracture

Destroy target artifact, enchantment, or planeswalker.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Despark

Exile target permanent with mana value 4 or greater.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Necromantic Selection

Destroy all creatures, then return a creature card put into a graveyard this way to the battlefield under your control. It's a black Zombie in addition to its other colors and types. Exile Necromantic Selection.

Marble Diamond

Marble Diamond enters the battlefield tapped.
{T}: Add {W}.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Fraying Omnipotence

Each player loses half their life, then discards half the cards in their hand, then sacrifices half the creatures they control. Round up each time.

Damnable Pact

Target player draws X cards and loses X life.

Soul Channeling

Enchant creature
Pay 2 life: Regenerate enchanted creature.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Death Grasp

Death Grasp deals X damage to any target. You gain X life.

Myriad Landscape

Myriad Landscape enters the battlefield tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Scourge of the Skyclaves

Kicker {4}{B}
When you cast this spell, if it was kicked, each player loses half their life, rounded up.
Scourge of the Skyclaves's power and toughness are each equal to 20 minus the highest life total among players.

Celestial Mantle

Enchant creature
Enchanted creature gets +3/+3.
Whenever enchanted creature deals combat damage to a player, double its controller's life total.

Sign in Blood

Target player draws two cards and loses 2 life.

Astarion, the Decadent

Deathtouch, lifelink
At the beginning of your end step, choose one —
• Feed — Target opponent loses life equal to the amount of life they lost this turn.
• Friends — You gain life equal to the amount of life you gained this turn.

Swamp

Felidar Sovereign

Vigilance, lifelink
At the beginning of your upkeep, if you have 40 or more life, you win the game.