Defenestrate

Skyfisher Spider

Reach
When Skyfisher Spider enters, you may sacrifice another creature. When you do, destroy target nonland permanent.
When Skyfisher Spider dies, you may gain 1 life for each creature card in your graveyard. If you do, exile Skyfisher Spider from your graveyard.

Infernal Grasp

Destroy target creature. You lose 2 life.

Cut Down

Destroy target creature with total power and toughness 5 or less.

Deadly Derision

Destroy target creature or planeswalker. Create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Akawalli, the Seething Tower

Descend 4 — As long as there are four or more permanent cards in your graveyard, Akawalli, the Seething Tower gets +2/+2 and has trample.
Descend 8 — As long as there are eight or more permanent cards in your graveyard, Akawalli gets an additional +2/+2 and can't be blocked by more than one creature.

Battle-Rage Blessing

Target creature gains deathtouch and indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Tamiyo's Safekeeping

Target permanent you control gains hexproof and indestructible until end of turn. You gain 2 life. (A permanent with hexproof and indestructible can't be the target of spells or abilities your opponents control. Damage and effects that say "destroy" don't destroy it.)

Boseiju, Who Endures

{T}: Add {G}.
Channel — {1}{G}, Discard Boseiju, Who Endures: Destroy target artifact, enchantment, or nonbasic land an opponent controls. That player may search their library for a land card with a basic land type, put it onto the battlefield, then shuffle. This ability costs {1} less to activate for each legendary creature you control.

Bitter Triumph

As an additional cost to cast this spell, discard a card or pay 3 life.
Destroy target creature or planeswalker.

Hero's Downfall

Atraxa's Fall

Destroy target artifact, battle, enchantment, or creature with flying.

Foul Play

Destroy target creature with power 2 or less. Investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Glissa Sunslayer

First strike, deathtouch
Whenever Glissa Sunslayer deals combat damage to a player, choose one —
• You draw a card and you lose 1 life.
• Destroy target enchantment.
• Remove up to three counters from target permanent.

Powerstone Fracture

As an additional cost to cast this spell, sacrifice an artifact or creature.
Destroy target creature or planeswalker.

Go for the Throat

Gaea's Gift

Put a +1/+1 counter on target creature you control. It gains reach, trample, hexproof, and indestructible until end of turn. (It can't be the target of spells or abilities your opponents control. Damage and effects that say "destroy" don't destroy it.)

Bone Splinters

As an additional cost to cast this spell, sacrifice a creature.
Destroy target creature.

Assassin's Ink

This spell costs {1} less to cast if you control an artifact and {1} less to cast if you control an enchantment.
Destroy target creature or planeswalker.

Annihilating Glare

As an additional cost to cast this spell, pay {4} or sacrifice an artifact or creature.
Destroy target creature or planeswalker.