Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature.
• Each opponent sacrifices a creature token.
• Each opponent sacrifices a planeswalker.

Lazotep Convert

You may have Lazotep Convert enter the battlefield as a copy of any creature card in a graveyard, except it's a 4/4 black Zombie in addition to its other colors and types.

Invasion of Amonkhet

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Amonkhet enters the battlefield, each player mills three cards, then each opponent discards a card and you draw a card. (To mill three cards, a player puts the top three cards of their library into their graveyard.)

Invasion of Amonkhet // Lazotep Convert

Mountain

Etali, Primal Sickness

Trample, indestructible
Whenever Etali, Primal Sickness deals combat damage to a player, they get that many poison counters. (A player with ten or more poison counters loses the game.)

Etali, Primal Conqueror

Trample
When Etali, Primal Conqueror enters the battlefield, each player exiles cards from the top of their library until they exile a nonland card. You may cast any number of spells from among the nonland cards exiled this way without paying their mana costs.
{9}{G/P}: Transform Etali. Activate only as a sorcery.

Etali, Primal Conqueror // Etali, Primal Sickness

Marchesa, Resolute Monarch

Menace, deathtouch
Whenever Marchesa, Resolute Monarch attacks, remove all counters from up to one target permanent.
At the beginning of your upkeep, if you haven't been dealt combat damage since your last turn, you draw a card and you lose 1 life.

Invasion of Fiora

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Fiora enters the battlefield, choose one or both —
• Destroy all legendary creatures.
• Destroy all nonlegendary creatures.

Invasion of Fiora // Marchesa, Resolute Monarch

Render Inert

Remove up to five counters from target permanent.
Draw a card.

Reezug, the Bonecobbler

{T}: Target creature card in your graveyard perpetually becomes an artifact. You may cast that card this turn. (It loses all other card types.)

Palantír of Orthanc

At the beginning of your end step, put an influence counter on Palantír of Orthanc and scry 2. Then target opponent may have you draw a card. If that player doesn't, you mill X cards, where X is the number of influence counters on Palantír of Orthanc, and that player loses life equal to the total mana value of those cards.

Dismal Backwater

Dismal Backwater enters the battlefield tapped.
When Dismal Backwater enters the battlefield, you gain 1 life.
{T}: Add {U} or {B}.

Timeless Lotus

Timeless Lotus enters the battlefield tapped.
{T}: Add {W}{U}{B}{R}{G}.

Deluge of the Dead

When Deluge of the Dead enters the battlefield, create two 2/2 black Zombie creature tokens.
{2}{B}: Exile target card from a graveyard. If it was a creature card, create a 2/2 black Zombie creature token.

Invasion of Innistrad

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
Flash
When Invasion of Innistrad enters the battlefield, target creature an opponent controls gets -13/-13 until end of turn.

Invasion of Innistrad // Deluge of the Dead

Murder

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Locthwain Scorn

Target creature gets -3/-3 until end of turn. You gain 2 life.

Virtue of Persistence

At the beginning of your upkeep, put target creature card from a graveyard onto the battlefield under your control.

Virtue of Persistence // Locthwain Scorn

Atraxa, Grand Unifier

Flying, vigilance, deathtouch, lifelink
When Atraxa, Grand Unifier enters the battlefield, reveal the top ten cards of your library. For each card type, you may put a card of that type from among the revealed cards into your hand. Put the rest on the bottom of your library in a random order. (Artifact, battle, creature, enchantment, instant, land, planeswalker, and sorcery are card types.)

Liliana of the Veil

+1: Each player discards a card.
−2: Target player sacrifices a creature.
−6: Separate all permanents target player controls into two piles. That player sacrifices all permanents in the pile of their choice.

Island

Vampire Opportunist

{6}{B}: Each opponent loses 2 life and you gain 2 life.

Go for the Throat

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Swamp

Bloodfell Caves

Bloodfell Caves enters the battlefield tapped.
When Bloodfell Caves enters the battlefield, you gain 1 life.
{T}: Add {B} or {R}.

The True Scriptures

(As this Saga enters and after your draw step, add a lore counter.)
I — For each opponent, destroy up to one target creature or planeswalker that player controls.
II — Each opponent discards three cards, then mills three cards.
III — Put all creature cards from all graveyards onto the battlefield under your control. Exile The True Scriptures, then return it to the battlefield (front face up).

Sheoldred

Menace
When Sheoldred enters the battlefield, each opponent sacrifices a nontoken creature or planeswalker.
{4}{B}: Exile Sheoldred, then return it to the battlefield transformed under its owner's control. Activate only as a sorcery and only if an opponent has eight or more cards in their graveyard.

Sheoldred // The True Scriptures

The Elder Dragon War

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — The Elder Dragon War deals 2 damage to each creature and each opponent.
II — Discard any number of cards, then draw that many cards.
III — Create a 4/4 red Dragon creature token with flying.