Ulamog, the Infinite Gyre

When you cast this spell, destroy target permanent.
Indestructible
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents of their choice.)
When Ulamog, the Infinite Gyre is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.

Manalith

Kazuul, Tyrant of the Cliffs

Whenever a creature an opponent controls attacks, if you're the defending player, create a 3/3 red Ogre creature token unless that creature's controller pays {3}.

Consume the Meek

Destroy each creature with mana value 3 or less. They can't be regenerated.

Leaden Myr

Inferno Titan

{R}: Inferno Titan gets +1/+0 until end of turn.
Whenever Inferno Titan enters or attacks, it deals 3 damage divided as you choose among one, two, or three targets.

Rakdos, Lord of Riots

You can't cast Rakdos, Lord of Riots unless an opponent lost life this turn.
Flying, trample
Creature spells you cast cost {1} less to cast for each 1 life your opponents have lost this turn.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Plague Myr

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{T}: Add {C}.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Blightsteel Colossus

Trample, infect, indestructible
If Blightsteel Colossus would be put into a graveyard from anywhere, reveal Blightsteel Colossus and shuffle it into its owner's library instead.

Sword of War and Peace

Equipped creature gets +2/+2 and has protection from red and from white.
Whenever equipped creature deals combat damage to a player, Sword of War and Peace deals damage to that player equal to the number of cards in their hand and you gain 1 life for each card in your hand.
Equip {2}

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Pilgrim's Eye

Flying
When Pilgrim's Eye enters, you may search your library for a basic land card, reveal it, put it into your hand, then shuffle.

Sign in Blood

Target player draws two cards and loses 2 life.

Phyrexian Rager

When Phyrexian Rager enters, you draw a card and you lose 1 life.

Mountain

Vampire Hexmage

First strike
Sacrifice Vampire Hexmage: Remove all counters from target permanent.

Fling

As an additional cost to cast this spell, sacrifice a creature.
Fling deals damage equal to the sacrificed creature's power to any target.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Trailblazer's Boots

Equipped creature has nonbasic landwalk. (It can't be blocked as long as defending player controls a nonbasic land.)
Equip {2}

Pestilence Demon

Flying
{B}: Pestilence Demon deals 1 damage to each creature and each player.

Chain Reaction

Chain Reaction deals X damage to each creature, where X is the number of creatures on the battlefield.

Ob Nixilis, the Fallen

Landfall — Whenever a land you control enters, you may have target player lose 3 life. If you do, put three +1/+1 counters on Ob Nixilis, the Fallen.

Butcher of Malakir

Flying
Whenever Butcher of Malakir or another creature you control dies, each opponent sacrifices a creature of their choice.

Dreamstone Hedron

{T}: Add {C}{C}{C}.
{3}, {T}, Sacrifice Dreamstone Hedron: Draw three cards.

Massacre Wurm

When Massacre Wurm enters, creatures your opponents control get -2/-2 until end of turn.
Whenever a creature an opponent controls dies, that player loses 2 life.

Leyline of Punishment

If Leyline of Punishment is in your opening hand, you may begin the game with it on the battlefield.
Players can't gain life.
Damage can't be prevented.

Life's Finale

Destroy all creatures, then search target opponent's library for up to three creature cards and put them into their graveyard. Then that player shuffles.

Iron Myr

Pulse Tracker

Whenever Pulse Tracker attacks, each opponent loses 1 life.

Swamp

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Blistergrub

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
When Blistergrub dies, each opponent loses 2 life.

Palladium Myr

Solemn Simulacrum

When Solemn Simulacrum enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When Solemn Simulacrum dies, you may draw a card.

Go for the Throat

Kozilek, Butcher of Truth

When you cast this spell, draw four cards.
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents of their choice.)
When Kozilek, Butcher of Truth is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.