Sign in Blood

Target player draws two cards and loses 2 life.

Phyrexian Colossus

Phyrexian Colossus doesn't untap during your untap step.
Pay 8 life: Untap Phyrexian Colossus.
Phyrexian Colossus can't be blocked except by three or more creatures.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Bitterblossom

At the beginning of your upkeep, you lose 1 life and create a 1/1 black Faerie Rogue creature token with flying.

Malakir Soothsayer

Cohort — {T}, Tap an untapped Ally you control: You draw a card and you lose 1 life.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Mortify

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Neva, Stalked by Nightmares

Menace
When Neva, Stalked by Nightmares enters, return target creature or enchantment card from your graveyard to your hand.
Whenever an enchantment you control is put into a graveyard from the battlefield, put a +1/+1 counter on Neva, then scry 1.

Annex Sentry

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
When Annex Sentry enters, exile target artifact or creature an opponent controls with mana value 3 or less until Annex Sentry leaves the battlefield.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Grand Abolisher

During your turn, your opponents can't cast spells or activate abilities of artifacts, creatures, or enchantments.

Reassembling Skeleton

{1}{B}: Return this card from your graveyard to the battlefield tapped.

Dark Ritual

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Mavren Fein, Dusk Apostle

Whenever one or more nontoken Vampires you control attack, create a 1/1 white Vampire creature token with lifelink.

Suture Priest

Whenever another creature you control enters, you may gain 1 life.
Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Erebos's Intervention

Choose one —
• Target creature gets -X/-X until end of turn. You gain X life.
• Exile up to twice X target cards from graveyards.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Vona, Butcher of Magan

Vigilance, lifelink
{T}, Pay 7 life: Destroy target nonland permanent. Activate only during your turn.

Vindicate

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Pestilence Demon

Flying
{B}: Pestilence Demon deals 1 damage to each creature and each player.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Disenchant

Midnight Reaper

Whenever a nontoken creature you control dies, this creature deals 1 damage to you and you draw a card.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Damnation

Destroy all creatures. They can't be regenerated.

Take It Back

Return target spell to its owner's hand. (Then exile this card. You may cast the creature later from exile.)

Spellscorn Coven

Flying
When Spellscorn Coven enters, each opponent discards a card.

Spellscorn Coven // Take It Back

Bontu the Glorified

Menace, indestructible
Bontu the Glorified can't attack or block unless a creature died under your control this turn.
{1}{B}, Sacrifice another creature: Scry 1. Each opponent loses 1 life and you gain 1 life.

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Nekusar, the Mindrazer

At the beginning of each player's draw step, that player draws an additional card.
Whenever an opponent draws a card, Nekusar, the Mindrazer deals 1 damage to that player.

Butcher Ghoul

Undying (When this creature dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Vampiric Rites

{1}{B}, Sacrifice a creature: You gain 1 life and draw a card.

Drivnod, Carnage Dominus

If a creature dying causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.
{B/P}{B/P}, Exile three creature cards from your graveyard: Put an indestructible counter on Drivnod, Carnage Dominus. ({B/P} can be paid with either {B} or 2 life.)

Phyrexian Reclamation

{1}{B}, Pay 2 life: Return target creature card from your graveyard to your hand.

Faith's Reward

Return to the battlefield all permanent cards in your graveyard that were put there from the battlefield this turn.

Shadowheart, Dark Justiciar

{1}{B}, {T}, Sacrifice another creature: Draw X cards, where X is that creature's power.
Choose a Background (You can have a Background as a second commander.)

Plumb the Forbidden

As an additional cost to cast this spell, you may sacrifice one or more creatures. When you do, copy this spell for each creature sacrificed this way.
You draw a card and you lose 1 life.

Toxic Abomination

When Toxic Abomination enters, you lose 2 life.

Werefox Bodyguard

Flash
When Werefox Bodyguard enters, exile up to one other target non-Fox creature until Werefox Bodyguard leaves the battlefield.
{1}{W}, Sacrifice Werefox Bodyguard: You gain 2 life.

Myrkul, Lord of Bones

As long as your life total is less than or equal to half your starting life total, Myrkul, Lord of Bones has indestructible.
Whenever another nontoken creature you control dies, you may exile it. If you do, create a token that's a copy of that card, except it's an enchantment and loses all other card types.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters, each player loses a third of their life, rounded up.

Bishop's Soldier

Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Greater Auramancy

Other enchantments you control have shroud. (A permanent with shroud can't be the target of spells or abilities.)
Enchanted creatures you control have shroud.

Inkshield

Prevent all combat damage that would be dealt to you this turn. For each 1 damage prevented this way, create a 2/1 white and black Inkling creature token with flying.

Leyline of Sanctity

If Leyline of Sanctity is in your opening hand, you may begin the game with it on the battlefield.
You have hexproof. (You can't be the target of spells or abilities your opponents control.)

Syr Gwyn, Hero of Ashvale

Vigilance, menace
Whenever an equipped creature you control attacks, you draw a card and you lose 1 life.
Equipment you control have equip Knight {0}.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Leechridden Swamp

({T}: Add {B}.)
Leechridden Swamp enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Wasteland Scorpion

Deathtouch
Cycling {2} ({2}, Discard this card: Draw a card.)

Night's Whisper

Skirsdag High Priest

Morbid — {T}, Tap two untapped creatures you control: Create a 5/5 black Demon creature token with flying. Activate only if a creature died this turn.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Carnival of Souls

Whenever a creature enters, you lose 1 life and add {B}.

Agatha's Soul Cauldron

You may spend mana as though it were mana of any color to activate abilities of creatures you control.
Creatures you control with +1/+1 counters on them have all activated abilities of all creature cards exiled with Agatha's Soul Cauldron.
{T}: Exile target card from a graveyard. When a creature card is exiled this way, put a +1/+1 counter on target creature you control.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Vigilant Martyr

Sacrifice Vigilant Martyr: Regenerate target creature.
{W}{W}, {T}, Sacrifice Vigilant Martyr: Counter target spell that targets an enchantment.

Stingblade Assassin

Flash
Flying
When Stingblade Assassin enters, destroy target creature an opponent controls that was dealt damage this turn.

Immortal Servitude

Return each creature card with mana value X from your graveyard to the battlefield.

Nether Void

Whenever a player casts a spell, counter it unless that player pays {3}.

Kuro, Pitlord

At the beginning of your upkeep, sacrifice Kuro, Pitlord unless you pay {B}{B}{B}{B}.
Pay 1 life: Target creature gets -1/-1 until end of turn.

Erebos, Bleak-Hearted

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature.
Whenever another creature you control dies, you may pay 2 life. If you do, draw a card.
{1}{B}, Sacrifice another creature: Target creature gets -2/-1 until end of turn.

Dire Fleet Hoarder

When Dire Fleet Hoarder dies, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Malakir Cullblade

Whenever a creature an opponent controls dies, put a +1/+1 counter on Malakir Cullblade.

Dark Prophecy

Whenever a creature you control dies, you draw a card and you lose 1 life.

Winds of Abandon

Exile target creature you don't control. For each creature exiled this way, its controller searches their library for a basic land card. Those players put those cards onto the battlefield tapped, then shuffle.
Overload {4}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

First-Sphere Gargantua

When First-Sphere Gargantua enters, you draw a card and you lose 1 life.
Unearth {2}{B} ({2}{B}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Discerning Financier

At the beginning of your upkeep, if an opponent controls more lands than you, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")
{2}{W}: Choose another player. That player gains control of target Treasure you control. You draw a card.

Selenia, Dark Angel

Flying
Pay 2 life: Return Selenia, Dark Angel to its owner's hand.

Dire Fleet Poisoner

Flash
Deathtouch
When Dire Fleet Poisoner enters, target attacking Pirate you control gets +1/+1 and gains deathtouch until end of turn.

Altar's Reap

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

Corrupted Roots

Enchant Forest or Plains
Whenever enchanted land becomes tapped, its controller loses 2 life.

War Room

{T}: Add {C}.
{3}, {T}, Pay life equal to the number of colors in your commanders' color identity: Draw a card.

Clattering Augur

Clattering Augur can't block.
When Clattering Augur enters, you draw a card and you lose 1 life.
{2}{B}{B}: Return Clattering Augur from your graveyard to your hand.

Bone Splinters

As an additional cost to cast this spell, sacrifice a creature.
Destroy target creature.

Ravenous Harpy

Flying
{1}, Sacrifice another creature: Put a +1/+1 counter on Ravenous Harpy.

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Despark

Exile target permanent with mana value 4 or greater.

Reliquary Tower

Infernal Grasp

Destroy target creature. You lose 2 life.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Korlash, Heir to Blackblade

Korlash, Heir to Blackblade's power and toughness are each equal to the number of Swamps you control.
{1}{B}: Regenerate Korlash.
Grandeur — Discard another card named Korlash, Heir to Blackblade: Search your library for up to two Swamp cards, put them onto the battlefield tapped, then shuffle.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Corrupted Harvester

{B}, Sacrifice a creature: Regenerate Corrupted Harvester.

Castle Ardenvale

Castle Ardenvale enters tapped unless you control a Plains.
{T}: Add {W}.
{2}{W}{W}, {T}: Create a 1/1 white Human creature token.

Oubliette

When Oubliette enters, target creature phases out until Oubliette leaves the battlefield. Tap that creature as it phases in this way. (Auras and Equipment phase out with it. While permanents are phased out, they're treated as though they don't exist.)

Exsanguinator Cavalry

Menace, lifelink
Whenever a Knight you control deals combat damage to a player, put a +1/+1 counter on that creature and create a Blood token. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this artifact: Draw a card.")

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Rune-Scarred Demon

Flying
When this creature enters, search your library for a card, put it into your hand, then shuffle.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.