Go for the Throat

Ulamog, the Infinite Gyre

When you cast this spell, destroy target permanent.
Indestructible
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents of their choice.)
When Ulamog is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.

Death Cloud

Each player loses X life, discards X cards, sacrifices X creatures of their choice, then sacrifices X lands of their choice.

Torment of Scarabs

Enchant player
At the beginning of enchanted player's upkeep, that player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.

Nether Spirit

At the beginning of your upkeep, if this card is the only creature card in your graveyard, you may return this card to the battlefield.

Doom Blade

Phyrexian Totem

{T}: Add {B}.
{2}{B}: This artifact becomes a 5/5 black Phyrexian Horror artifact creature with trample until end of turn.
Whenever this permanent is dealt damage, if it's a creature, sacrifice that many permanents.

Hatred

As an additional cost to cast this spell, pay X life.
Target creature gets +X/+0 until end of turn.

Lake of the Dead

If this land would enter, sacrifice a Swamp instead. If you do, put this land onto the battlefield. If you don't, put it into its owner's graveyard.
{T}: Add {B}.
{T}, Sacrifice a Swamp: Add {B}{B}{B}{B}.

Contamination

At the beginning of your upkeep, sacrifice this enchantment unless you sacrifice a creature.
If a land is tapped for mana, it produces {B} instead of any other type and amount.

Smokestack

At the beginning of your upkeep, you may put a soot counter on this artifact.
At the beginning of each player's upkeep, that player sacrifices a permanent of their choice for each soot counter on this artifact.

Sudden Spoiling

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Until end of turn, creatures target player controls lose all abilities and have base power and toughness 0/2.

Dash Hopes

When you cast this spell, any player may pay 5 life. If a player does, counter Dash Hopes.
Counter target spell.

Choking Sands

Destroy target non-Swamp land. If that land was nonbasic, Choking Sands deals 2 damage to the land's controller.

Pain's Reward

Each player may bid life. You start the bidding with a bid of any number. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and draws four cards.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Innocent Blood

Each player sacrifices a creature of their choice.

Lethal Vapors

Whenever a creature enters, destroy it.
{0}: Destroy this enchantment. You skip your next turn. Any player may activate this ability.

Desolation

At the beginning of each end step, each player who tapped a land for mana this turn sacrifices a land of their choice. This enchantment deals 2 damage to each player who sacrificed a Plains this way.

Tragic Slip

Target creature gets -1/-1 until end of turn.
Morbid — That creature gets -13/-13 until end of turn instead if a creature died this turn.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Psychotic Episode

Target player reveals their hand and the top card of their library. You choose a card revealed this way. That player puts the chosen card on the bottom of their library.
Madness {1}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Pithing Needle

As this artifact enters, choose a card name.
Activated abilities of sources with the chosen name can't be activated unless they're mana abilities.

Braids, Cabal Minion

At the beginning of each player's upkeep, that player sacrifices an artifact, creature, or land of their choice.

Bubbling Muck

Until end of turn, whenever a player taps a Swamp for mana, that player adds an additional {B}.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Strip Mine

{T}: Add {C}.
{T}, Sacrifice this land: Destroy target land.

Praetor's Grasp

Search target opponent's library for a card and exile it face down. Then that player shuffles. You may play that card for as long as it remains exiled.

Sign in Blood

Target player draws two cards and loses 2 life.

Temporal Extortion

When you cast this spell, any player may pay half their life, rounded up. If a player does, counter Temporal Extortion.
Take an extra turn after this one.

Rankle's Prank

Choose one or more —
• Each player discards two cards.
• Each player loses 4 life.
• Each player sacrifices two creatures of their choice.

Diabolic Intent

As an additional cost to cast this spell, sacrifice a creature.
Search your library for a card, put that card into your hand, then shuffle.

Megrim

Whenever an opponent discards a card, this enchantment deals 2 damage to that player.

Spreading Plague

Whenever a creature enters, destroy all other creatures that share a color with it. They can't be regenerated.

Befoul

Destroy target land or nonblack creature. It can't be regenerated.

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Shrouded Lore

Target opponent chooses a card in your graveyard. You may pay {B}. If you do, repeat this process except that opponent can't choose a card already chosen for Shrouded Lore. Then put the last chosen card into your hand.

Darkness

Prevent all combat damage that would be dealt this turn.

Tyrant's Choice

Will of the council — Starting with you, each player votes for death or torture. If death gets more votes, each opponent sacrifices a creature of their choice. If torture gets more votes or the vote is tied, each opponent loses 4 life.

Rancid Earth

Destroy target land.
Threshold — If seven or more cards are in your graveyard, instead destroy that land and Rancid Earth deals 1 damage to each creature and each player.

Library of Leng

You have no maximum hand size.
If an effect causes you to discard a card, discard it, but you may put it on top of your library instead of into your graveyard.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Tomb of Urami

{T}: Add {B}. Tomb of Urami deals 1 damage to you if you don't control an Ogre.
{2}{B}{B}, {T}, Sacrifice all lands you control: Create Urami, a legendary 5/5 black Demon Spirit creature token with flying.

Sadistic Sacrament

Kicker {7} (You may pay an additional {7} as you cast this spell.)
Search target player's library for up to three cards, exile them, then that player shuffles. If this spell was kicked, instead search that player's library for up to fifteen cards, exile them, then that player shuffles.

Inquisition of Kozilek

Target player reveals their hand. You choose a nonland card from it with mana value 3 or less. That player discards that card.

Hymn to Tourach

Target player discards two cards at random.

Genju of the Fens

Enchant Swamp
{2}: Until end of turn, enchanted Swamp becomes a 2/2 black Spirit creature with "{B}: This creature gets +1/+1 until end of turn." It's still a land.
When enchanted Swamp is put into a graveyard, you may return this card from your graveyard to your hand.

Fatal Push

Destroy target creature if it has mana value 2 or less.
Revolt — Destroy that creature if it has mana value 4 or less instead if a permanent left the battlefield under your control this turn.

Raven's Crime

Target player discards a card.
Retrace (You may cast this card from your graveyard by discarding a land card in addition to paying its other costs.)

Kaervek's Spite

As an additional cost to cast this spell, sacrifice all permanents you control and discard your hand.
Target player loses 5 life.

Victim of Night

Destroy target non-Vampire, non-Werewolf, non-Zombie creature.

Oppression

Whenever a player casts a spell, that player discards a card.

Culling Scales

At the beginning of your upkeep, destroy target nonland permanent with the lowest mana value. (If two or more permanents are tied for lowest, target any one of them.)

Bitter Ordeal

Search target player's library for a card and exile it. Then that player shuffles.
Gravestorm (When you cast this spell, copy it for each permanent put into a graveyard this turn. You may choose new targets for the copies.)

Liliana of the Veil

+1: Each player discards a card.
−2: Target player sacrifices a creature.
−6: Separate all permanents target player controls into two piles. That player sacrifices all permanents in the pile of their choice.

Chain of Smog

Target player discards two cards. That player may copy this spell and may choose a new target for that copy.

Swamp

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control of their choice, then sacrifices a third of the lands they control of their choice. Round up each time.

Ensnaring Bridge

Creatures with power greater than the number of cards in your hand can't attack.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Tainted Aether

Whenever a creature enters, its controller sacrifices a creature or land of their choice.

Seizures

Enchant creature
Whenever enchanted creature becomes tapped, this Aura deals 3 damage to that creature's controller unless that player pays {3}.

Blight

Enchant land
When enchanted land becomes tapped, destroy it.

Cabal Ritual

Add {B}{B}{B}.
Threshold — Add {B}{B}{B}{B}{B} instead if seven or more cards are in your graveyard.

Lurking Jackals

When an opponent has 10 or less life, if this permanent is an enchantment, it becomes a 3/2 Jackal creature.

Mind Swords

If you control a Swamp, you may sacrifice a creature rather than pay this spell's mana cost.
Each player exiles two cards from their hand.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on this enchantment.
At the beginning of each opponent's upkeep, if that player has no cards in hand and this enchantment has two or more quest counters on it, you may have that player lose 5 life.

Nameless Inversion

Changeling (This card is every creature type.)
Target creature gets +3/-3 and loses all creature types until end of turn.

Infest

All creatures get -2/-2 until end of turn.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

Season of the Witch

At the beginning of your upkeep, sacrifice this enchantment unless you pay 2 life.
At the beginning of the end step, destroy all untapped creatures that didn't attack this turn, except for creatures that couldn't attack.

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Shrivel

All creatures get -1/-1 until end of turn.

Sinkhole

Gate to Phyrexia

Sacrifice a creature: Destroy target artifact. Activate only during your upkeep and only once each turn.

Phyrexian Obliterator

Trample
Whenever a source deals damage to this creature, that source's controller sacrifices that many permanents of their choice.

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Demonic Consultation

Choose a card name. Exile the top six cards of your library, then reveal cards from the top of your library until you reveal a card with the chosen name. Put that card into your hand and exile all other cards revealed this way.

Ashes to Ashes

Exile two target nonartifact creatures. Ashes to Ashes deals 5 damage to you.

Extract the Truth

Choose one —
• Target opponent reveals their hand. You may choose a creature, enchantment, or planeswalker card from it. That player discards that card.
• Target opponent sacrifices an enchantment of their choice.