Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Scourglass

{T}, Sacrifice Scourglass: Destroy all permanents except for artifacts and lands. Activate only during your upkeep.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Planar Collapse

At the beginning of your upkeep, if there are four or more creatures on the battlefield, sacrifice Planar Collapse and destroy all creatures. They can't be regenerated.

Hazoret the Fervent

Indestructible, haste
Hazoret the Fervent can't attack or block unless you have one or fewer cards in hand.
{2}{R}, Discard a card: Hazoret deals 2 damage to each opponent.

Damnation

Destroy all creatures. They can't be regenerated.

Blot Out the Sky

Create X tapped 2/1 white and black Inkling creature tokens with flying. If X is 6 or more, destroy all noncreature, nonland permanents.

Day of Judgment

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Tajic, Blade of the Legion

Indestructible
Battalion — Whenever Tajic, Blade of the Legion and at least two other creatures attack, Tajic gets +5/+5 until end of turn.

Deathbringer Regent

Flying
When Deathbringer Regent enters, if you cast it from your hand and there are five or more other creatures on the battlefield, destroy all other creatures.

Planar Cleansing

Sublime Exhalation

Undaunted (This spell costs {1} less to cast for each opponent.)
Destroy all creatures.

Martial Coup

Create X 1/1 white Soldier creature tokens. If X is 5 or more, destroy all other creatures.

Ulamog, the Infinite Gyre

When you cast this spell, destroy target permanent.
Indestructible
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents of their choice.)
When Ulamog, the Infinite Gyre is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Structural Assault

Destroy all artifacts, then Structural Assault deals damage to each creature equal to the number of artifacts that were put into graveyards from the battlefield this turn.

Ruinous Ultimatum

Destroy all nonland permanents your opponents control.

Seraph of the Suns

Flying
Indestructible (Damage and effects that say "destroy" don't destroy this creature. If its toughness is 0 or less, it's still put into its owner's graveyard.)

Boompile

{T}: Flip a coin. If you win the flip, destroy all nonland permanents.

Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Worldslayer

Whenever equipped creature deals combat damage to a player, destroy all permanents other than Worldslayer.
Equip {5} ({5}: Attach to target creature you control. Equip only as a sorcery.)

Ritual of Soot

Destroy all creatures with mana value 3 or less.

Marchesa, Resolute Monarch

Menace, deathtouch
Whenever Marchesa, Resolute Monarch attacks, remove all counters from up to one target permanent.
At the beginning of your upkeep, if you haven't been dealt combat damage since your last turn, you draw a card and you lose 1 life.

Invasion of Fiora

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Fiora enters, choose one or both —
• Destroy all legendary creatures.
• Destroy all nonlegendary creatures.

Invasion of Fiora // Marchesa, Resolute Monarch

Karn's Sylex

Karn's Sylex enters tapped.
Players can't pay life to cast spells or to activate abilities that aren't mana abilities.
{X}, {T}, Exile Karn's Sylex: Destroy each nonland permanent with mana value X or less. Activate only as a sorcery.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Ondu Skyruins

Ondu Skyruins enters tapped.
{T}: Add {W}.

Ondu Inversion

Ondu Inversion // Ondu Skyruins

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Exterminatus

Nonland permanents your opponents control lose indestructible until end of turn.
Destroy all nonland permanents.

Zetalpa, Primal Dawn

Flying, double strike, vigilance, trample, indestructible

White Sun's Twilight

You gain X life. Create X 1/1 colorless Phyrexian Mite artifact creature tokens with toxic 1 and "This creature can't block." If X is 5 or more, destroy all other creatures. (Players dealt combat damage by a creature with toxic 1 also get a poison counter.)

Magus of the Disk

Magus of the Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Expel the Interlopers

Choose a number between 0 and 10. Destroy all creatures with power greater than or equal to the chosen number.

Cleanfall

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Athreos, Shroud-Veiled

Indestructible
As long as your devotion to white and black is less than seven, Athreos isn't a creature.
At the beginning of your end step, put a coin counter on another target creature.
Whenever a creature with a coin counter on it dies or is put into exile, return that card to the battlefield under your control.

Zurgo Helmsmasher

Haste
Zurgo Helmsmasher attacks each combat if able.
During your turn, Zurgo Helmsmasher has indestructible.
Whenever a creature dealt damage by Zurgo Helmsmasher this turn dies, put a +1/+1 counter on Zurgo Helmsmasher.

Tegwyll's Scouring

You may cast Tegwyll's Scouring as though it had flash by tapping three untapped creatures you control with flying in addition to paying its other costs.
Destroy all creatures. Create three 1/1 black Faerie Rogue creature tokens with flying.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Wrath of God

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Bontu the Glorified

Menace, indestructible
Bontu the Glorified can't attack or block unless a creature died under your control this turn.
{1}{B}, Sacrifice another creature: Scry 1. Each opponent loses 1 life and you gain 1 life.

Cast Off

Destroy all non-Giant creatures. (Then exile this card. You may cast the creature later from exile.)

Realm-Cloaked Giant

Realm-Cloaked Giant // Cast Off

Ulamog, the Ceaseless Hunger

When you cast this spell, exile two target permanents.
Indestructible
Whenever Ulamog, the Ceaseless Hunger attacks, defending player exiles the top twenty cards of their library.

Purify

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Mogis, God of Slaughter

Indestructible
As long as your devotion to black and red is less than seven, Mogis isn't a creature.
At the beginning of each opponent's upkeep, Mogis deals 2 damage to that player unless they sacrifice a creature of their choice.

Shatter the Sky

Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.

Blood on the Snow

Choose one —
• Destroy all creatures.
• Destroy all planeswalkers.
Then return a creature or planeswalker card with mana value X or less from your graveyard to the battlefield, where X is the amount of {S} spent to cast this spell. ({S} is mana from a snow source.)