Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Mind Rot

Hopeless Nightmare

When Hopeless Nightmare enters the battlefield, each opponent discards a card and loses 2 life.
When Hopeless Nightmare is put into a graveyard from the battlefield, scry 2.
{2}{B}: Sacrifice Hopeless Nightmare.

Go Blank

Target player discards two cards. Then exile that player's graveyard.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Elderfang Disciple

When Elderfang Disciple enters the battlefield, each opponent discards a card.

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Nezumi Informant

When Nezumi Informant enters the battlefield, each opponent discards a card.

Despise

Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.

Demogorgon's Clutches

Target opponent discards two cards, mills two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Hymn to Tourach

Target player discards two cards at random.

Divest

Target player reveals their hand. You choose an artifact or creature card from it. That player discards that card.

Davriel, Rogue Shadowmage

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, Davriel, Rogue Shadowmage deals 2 damage to them.
−1: Target player discards a card.

Dread Fugue

Cleave {2}{B} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Target player reveals their hand. You choose a nonland card from it [with mana value 2 or less]. That player discards that card.

Blackmail

Target player reveals three cards from their hand and you choose one of them. That player discards that card.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature, then sacrifices a land.

Liliana's Specter

Flying
When Liliana's Specter enters the battlefield, each opponent discards a card.

Gix, Yawgmoth Praetor

Whenever a creature deals combat damage to one of your opponents, its controller may pay 1 life. If they do, they draw a card.
{4}{B}{B}{B}, Discard X cards: Exile the top X cards of target opponent's library. You may play lands and cast spells from among cards exiled this way without paying their mana costs.

Inquisition of Kozilek

Target player reveals their hand. You choose a nonland card from it with mana value 3 or less. That player discards that card.

Mind Rake

Target player discards two cards.
Overload {1}{B} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters the battlefield, if it was kicked, target opponent discards two cards at random.

Hypnotic Specter

Flying
Whenever Hypnotic Specter deals damage to an opponent, that player discards a card at random.