Ruinous Ultimatum

Destroy all nonland permanents your opponents control.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Kaalia, Zenith Seeker

Flying, vigilance
When Kaalia, Zenith Seeker enters, look at the top six cards of your library. You may reveal an Angel card, a Demon card, and/or a Dragon card from among them and put them into your hand. Put the rest on the bottom of your library in a random order.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

All Is Dust

Each player sacrifices all permanents they control that are one or more colors.

Avacyn, Angel of Hope

Flying, vigilance, indestructible
Other permanents you control have indestructible.

Kaalia of the Vast

Flying
Whenever Kaalia of the Vast attacks an opponent, you may put an Angel, Demon, or Dragon creature card from your hand onto the battlefield tapped and attacking that opponent.

Reckless Endeavor

Roll two d12 and choose one result. Reckless Endeavor deals damage equal to that result to each creature. Then create a number of Treasure tokens equal to the other result.

Ondu Skyruins

Ondu Skyruins enters tapped.
{T}: Add {W}.

Ondu Inversion

Ondu Inversion // Ondu Skyruins

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Avacyn, the Purifier

Flying
When this creature transforms into Avacyn, the Purifier, it deals 3 damage to each other creature and each opponent.

Archangel Avacyn

Flash
Flying, vigilance
When Archangel Avacyn enters, creatures you control gain indestructible until end of turn.
When a non-Angel creature you control dies, transform Archangel Avacyn at the beginning of the next upkeep.

Archangel Avacyn // Avacyn, the Purifier

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Hour of Reckoning

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Destroy all nontoken creatures.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Day of Judgment

Wrath of God

Destroy all creatures. They can't be regenerated.

Chain Reaction

Chain Reaction deals X damage to each creature, where X is the number of creatures on the battlefield.