Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Thrull Parasite

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
{T}, Pay 2 life: Remove a counter from target nonland permanent.

Tithe Drinker

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Test of Endurance

At the beginning of your upkeep, if you have 50 or more life, you win the game.

Orzhov Basilica

Orzhov Basilica enters tapped.
When Orzhov Basilica enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Solemn Offering

Destroy target artifact or enchantment. You gain 4 life.

Gonti's Machinations

Whenever you lose life for the first time each turn, you get {E}. (You get an energy counter. Damage causes loss of life.)
Pay {E}{E}, Sacrifice Gonti's Machinations: Each opponent loses 3 life. You gain life equal to the life lost this way.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Light of Promise

Enchant creature
Enchanted creature has "Whenever you gain life, put that many +1/+1 counters on this creature."

City's Blessing

Sejiri Glacier

Sejiri Glacier enters tapped.
{T}: Add {W}.

Sejiri Shelter

Target creature you control gains protection from the color of your choice until end of turn.

Sejiri Shelter // Sejiri Glacier

Leyline of Sanctity

If Leyline of Sanctity is in your opening hand, you may begin the game with it on the battlefield.
You have hexproof. (You can't be the target of spells or abilities your opponents control.)

Temple of the False God

{T}: Add {C}{C}. Activate only if you control five or more lands.

Doubling Cube

{3}, {T}: Double the amount of each type of unspent mana you have.

Basilica Guards

Defender
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Tomb of the Dusk Rose

(Transforms from Profane Procession.)
{T}: Add one mana of any color.
{2}{W}{B}, {T}: Put a creature card exiled with this permanent onto the battlefield under your control.

Profane Procession

{3}{W}{B}: Exile target creature. Then if there are three or more cards exiled with Profane Procession, transform it.

Profane Procession // Tomb of the Dusk Rose

Pontiff of Blight

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Other creatures you control have extort. (If a creature has multiple instances of extort, each triggers separately.)

Maze of Ith

{T}: Untap target attacking creature. Prevent all combat damage that would be dealt to and dealt by that creature this turn.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform Chalice of Life.

Chalice of Life // Chalice of Death

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Soldier

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Scholar of Athreos

{2}{B}: Each opponent loses 1 life. You gain life equal to the life lost this way.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Syndic of Tithes

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Divine Offering

Destroy target artifact. You gain life equal to its mana value.

Opal Palace

{T}: Add {C}.
{1}, {T}: Add one mana of any color in your commander's color identity. If you spend this mana to cast your commander, it enters with a number of additional +1/+1 counters on it equal to the number of times it's been cast from the command zone this game.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Radiant Fountain

When Radiant Fountain enters, you gain 2 life.
{T}: Add {C}.

Plains

Norn's Annex

({W/P} can be paid with either {W} or 2 life.)
Creatures can't attack you or planeswalkers you control unless their controller pays {W/P} for each of those creatures.

Kabira Crossroads

Kabira Crossroads enters tapped.
When Kabira Crossroads enters, you gain 2 life.
{T}: Add {W}.

Angel of Vitality

Flying
If you would gain life, you gain that much life plus 1 instead.
This creature gets +2/+2 as long as you have 25 or more life.

Ob Nixilis of the Black Oath

+2: Each opponent loses 1 life. You gain life equal to the life lost this way.
−2: Create a 5/5 black Demon creature token with flying. You lose 2 life.
−8: You get an emblem with "{1}{B}, Sacrifice a creature: You gain X life and draw X cards, where X is the sacrificed creature's power."
Ob Nixilis of the Black Oath can be your commander.

Palace Siege

As Palace Siege enters, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Sorin, Solemn Visitor

+1: Until your next turn, creatures you control get +1/+0 and gain lifelink.
−2: Create a 2/2 black Vampire creature token with flying.
−6: You get an emblem with "At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice."

Orzhov Locket

{T}: Add {W} or {B}.
{W/B}{W/B}{W/B}{W/B}, {T}, Sacrifice Orzhov Locket: Draw two cards.

Loreseeker's Stone

{3}, {T}: Draw three cards. This ability costs {1} more to activate for each card in your hand.

Mana Crypt

At the beginning of your upkeep, flip a coin. If you lose the flip, Mana Crypt deals 3 damage to you.
{T}: Add {C}{C}.

Suture Priest

Whenever another creature you control enters, you may gain 1 life.
Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Ob Nixilis of the Black Oath Emblem

{1}{B}, Sacrifice a creature: You gain X life and draw X cards, where X is the sacrificed creature's power.

Basilica Screecher

Flying
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Kingpin's Pet

Treasure

{T}, Sacrifice this token: Add one mana of any color.

Staff of Nin

At the beginning of your upkeep, draw a card.
{T}: Staff of Nin deals 1 damage to any target.

Vault of Champions

Vault of Champions enters tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Aurora of Emrakul

Flying, deathtouch
Whenever Aurora of Emrakul attacks, each opponent loses 3 life.

Cryptolith Fragment

Cryptolith Fragment enters tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform Cryptolith Fragment.

Cryptolith Fragment // Aurora of Emrakul

Demon

Cradle of Vitality

Whenever you gain life, you may pay {1}{W}. If you do, put a +1/+1 counter on target creature for each 1 life you gained.

Ghostly Prison

Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Ancient Craving

You draw three cards and you lose 3 life.

Verrak, Warped Sengir

Flying, deathtouch, lifelink
Whenever you activate an ability that isn't a mana ability, if life was paid to activate it, you may pay that much life again. If you do, copy that ability. You may choose new targets for the copy.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Vampire Scrivener

Flying
Whenever you gain life during your turn, put a +1/+1 counter on Vampire Scrivener.
Whenever you lose life during your turn, put a +1/+1 counter on Vampire Scrivener.

Forsaken Sanctuary

Forsaken Sanctuary enters tapped.
{T}: Add {W} or {B}.

Terashi's Grasp

Destroy target artifact or enchantment. You gain life equal to its mana value.

Sorin, Solemn Visitor Emblem

At the beginning of each opponent's upkeep, that player sacrifices a creature.

Sunscorched Desert

When Sunscorched Desert enters, it deals 1 damage to target player or planeswalker.
{T}: Add {C}.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Survival Cache

You gain 2 life. Then if you have more life than an opponent, draw a card.
Rebound (If you cast this spell from your hand, exile it as it resolves. At the beginning of your next upkeep, you may cast this card from exile without paying its mana cost.)

Orazca Relic

Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
{T}: Add {C}.
{T}, Sacrifice Orazca Relic: You gain 3 life and draw a card. Activate only if you have the city's blessing.

Benevolent Blessing

Flash
Enchant creature
As Benevolent Blessing enters, choose a color.
Enchanted creature has protection from the chosen color. This effect doesn't remove Auras and Equipment you control that are already attached to it.

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Marble Diamond

Marble Diamond enters tapped.
{T}: Add {W}.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Vampire

Swamp

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Indulging Patrician

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your end step, if you gained 3 or more life this turn, each opponent loses 3 life.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Dawn of Hope

Whenever you gain life, you may pay {2}. If you do, draw a card.
{3}{W}: Create a 1/1 white Soldier creature token with lifelink.

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Pristine Talisman

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Hierophant's Chalice

When Hierophant's Chalice enters, target opponent loses 1 life and you gain 1 life.
{T}: Add {C}.

One Thousand Lashes

Enchant creature
Enchanted creature can't attack or block, and its activated abilities can't be activated.
At the beginning of the upkeep of enchanted creature's controller, that player loses 1 life.

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Damnable Pact

Target player draws X cards and loses X life.

Scoured Barrens

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {W} or {B}.

Orzhov Cluestone

{T}: Add {W} or {B}.
{W}{B}, {T}, Sacrifice Orzhov Cluestone: Draw a card.

Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Sorin, Vengeful Bloodlord

During your turn, creatures and planeswalkers you control have lifelink.
+2: Sorin, Vengeful Bloodlord deals 1 damage to target player or planeswalker.
−X: Return target creature card with mana value X from your graveyard to the battlefield. That creature is a Vampire in addition to its other types.

Soul Warden

Whenever another creature enters, you gain 1 life.