Decree of Annihilation

Exile all artifacts, creatures, and lands from the battlefield, all cards from all graveyards, and all cards from all hands.
Cycling {5}{R}{R} ({5}{R}{R}, Discard this card: Draw a card.)
When you cycle Decree of Annihilation, destroy all lands.

Stonehoof Chieftain

Trample, indestructible
Whenever another creature you control attacks, it gains trample and indestructible until end of turn.

Avacyn, Angel of Hope

Flying, vigilance, indestructible
Other permanents you control have indestructible.

Eerie Ultimatum

Return any number of permanent cards with different names from your graveyard to the battlefield.

Mountain

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Myojin of Infinite Rage

Myojin of Infinite Rage enters with a divinity counter on it if you cast it from your hand.
Myojin of Infinite Rage has indestructible as long as it has a divinity counter on it.
Remove a divinity counter from Myojin of Infinite Rage: Destroy all lands.

Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Raffine's Tower

({T}: Add {W}, {U}, or {B}.)
Raffine's Tower enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Jetmir's Garden

({T}: Add {R}, {G}, or {W}.)
Jetmir's Garden enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Exterminatus

Nonland permanents your opponents control lose indestructible until end of turn.
Destroy all nonland permanents.

Island

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Multani's Decree

Destroy all enchantments. You gain 2 life for each enchantment destroyed this way.

Ziatora's Proving Ground

({T}: Add {B}, {R}, or {G}.)
Ziatora's Proving Ground enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Bearer of the Heavens

When Bearer of the Heavens dies, destroy all permanents at the beginning of the next end step.

Drossforge Bridge

Drossforge Bridge enters tapped.
Indestructible
{T}: Add {B} or {R}.

Conduit of Worlds

You may play lands from your graveyard.
{T}: Choose target nonland permanent card in your graveyard. If you haven't cast a spell this turn, you may cast that card. If you do, you can't cast additional spells this turn. Activate only as a sorcery.

Rise of the Dark Realms

Put all creature cards from all graveyards onto the battlefield under your control.

Serenity

At the beginning of your upkeep, destroy all artifacts and enchantments. They can't be regenerated.

Path of Ancestry

Path of Ancestry enters tapped.
{T}: Add one mana of any color in your commander's color identity. When that mana is spent to cast a creature spell that shares a creature type with your commander, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Planar Collapse

At the beginning of your upkeep, if there are four or more creatures on the battlefield, sacrifice Planar Collapse and destroy all creatures. They can't be regenerated.

Cloudshredder Sliver

Sliver creatures you control have flying and haste.

Paraselene

Destroy all enchantments. You gain 1 life for each enchantment destroyed this way.

Spara's Headquarters

({T}: Add {G}, {W}, or {U}.)
Spara's Headquarters enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Bane of Progress

When Bane of Progress enters, destroy all artifacts and enchantments. Put a +1/+1 counter on Bane of Progress for each permanent destroyed this way.

Thornglint Bridge

Thornglint Bridge enters tapped.
Indestructible
{T}: Add {G} or {W}.

Ruination

Mistvault Bridge

Mistvault Bridge enters tapped.
Indestructible
{T}: Add {U} or {B}.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Slagwoods Bridge

Slagwoods Bridge enters tapped.
Indestructible
{T}: Add {R} or {G}.

Fracturing Gust

Destroy all artifacts and enchantments. You gain 2 life for each permanent destroyed this way.

Darksteel Citadel

Rustvale Bridge

Rustvale Bridge enters tapped.
Indestructible
{T}: Add {R} or {W}.

Obliterate

This spell can't be countered.
Destroy all artifacts, creatures, and lands. They can't be regenerated.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Swamp

Back to Nature

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Armageddon

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Darksteel Ingot

Indestructible (Effects that say "destroy" don't destroy this artifact.)
{T}: Add one mana of any color.

Razortide Bridge

Razortide Bridge enters tapped.
Indestructible
{T}: Add {W} or {U}.

Forest

Clever Concealment

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Any number of target nonland permanents you control phase out. (Treat them and anything attached to them as though they don't exist until your next turn.)

Damnation

Destroy all creatures. They can't be regenerated.

Xander's Lounge

({T}: Add {U}, {B}, or {R}.)
Xander's Lounge enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Crucible of Worlds

Shatterstorm

Destroy all artifacts. They can't be regenerated.

Plains

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Goldmire Bridge

Goldmire Bridge enters tapped.
Indestructible
{T}: Add {W} or {B}.

Sliver Hivelord

Sliver creatures you control have indestructible. (Damage and effects that say "destroy" don't destroy them.)

Fall of the Thran

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Destroy all lands.
II, III — Each player returns two land cards from their graveyard to the battlefield.

Xenagos, God of Revels

Indestructible
As long as your devotion to red and green is less than seven, Xenagos isn't a creature.
At the beginning of combat on your turn, another target creature you control gains haste and gets +X/+X until end of turn, where X is that creature's power.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Hush

Destroy all enchantments.
Cycling {2} ({2}, Discard this card: Draw a card.)

Novablast Wurm

Whenever Novablast Wurm attacks, destroy all other creatures.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Wrath of God

Chromatic Orrery

You may spend mana as though it were mana of any color.
{T}: Add {C}{C}{C}{C}{C}.
{5}, {T}: Draw a card for each color among permanents you control.

White Sun's Twilight

You gain X life. Create X 1/1 colorless Phyrexian Mite artifact creature tokens with toxic 1 and "This creature can't block." If X is 5 or more, destroy all other creatures. (Players dealt combat damage by a creature with toxic 1 also get a poison counter.)

Vandalblast

Destroy target artifact you don't control.
Overload {4}{R} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Ulamog, the Infinite Gyre

When you cast this spell, destroy target permanent.
Indestructible
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents of their choice.)
When Ulamog, the Infinite Gyre is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.

Darkmoss Bridge

Darkmoss Bridge enters tapped.
Indestructible
{T}: Add {B} or {G}.

Impending Disaster

At the beginning of your upkeep, if there are seven or more lands on the battlefield, sacrifice Impending Disaster and destroy all lands.

Athreos, Shroud-Veiled

Indestructible
As long as your devotion to white and black is less than seven, Athreos isn't a creature.
At the beginning of your end step, put a coin counter on another target creature.
Whenever a creature with a coin counter on it dies or is put into exile, return that card to the battlefield under your control.

Worldslayer

Whenever equipped creature deals combat damage to a player, destroy all permanents other than Worldslayer.
Equip {5} ({5}: Attach to target creature you control. Equip only as a sorcery.)

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Karametra, God of Harvests

Indestructible
As long as your devotion to green and white is less than seven, Karametra isn't a creature.
Whenever you cast a creature spell, you may search your library for a Forest or Plains card, put it onto the battlefield tapped, then shuffle.

Tanglepool Bridge

Tanglepool Bridge enters tapped.
Indestructible
{T}: Add {G} or {U}.

Blood Money

Destroy all creatures. For each nontoken creature destroyed this way, you create a tapped Treasure token.

Chromatic Lantern

Lands you control have "{T}: Add one mana of any color."
{T}: Add one mana of any color.

Devastation

Brash Taunter

Indestructible
Whenever Brash Taunter is dealt damage, it deals that much damage to target opponent.
{2}{R}, {T}: Brash Taunter fights another target creature.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Sol Ring

Zopandrel, Hunger Dominus

Reach
At the beginning of each combat, double the power and toughness of each creature you control until end of turn.
{G/P}{G/P}, Sacrifice two other creatures: Put an indestructible counter on Zopandrel, Hunger Dominus. ({G/P} can be paid with either {G} or 2 life.)

World Shaper

Whenever World Shaper attacks, you may mill three cards.
When World Shaper dies, return all land cards from your graveyard to the battlefield tapped.

Anger

Haste
As long as Anger is in your graveyard and you control a Mountain, creatures you control have haste.

Ruinous Ultimatum

Destroy all nonland permanents your opponents control.

Jokulhaups

Destroy all artifacts, creatures, and lands. They can't be regenerated.

Taurean Mauler

Changeling (This card is every creature type.)
Whenever an opponent casts a spell, you may put a +1/+1 counter on this creature.

Toski, Bearer of Secrets

This spell can't be countered.
Indestructible
Toski, Bearer of Secrets attacks each combat if able.
Whenever a creature you control deals combat damage to a player, draw a card.

Silverbluff Bridge

Silverbluff Bridge enters tapped.
Indestructible
{T}: Add {U} or {R}.

Cascading Cataracts

Indestructible
{T}: Add {C}.
{5}, {T}: Add five mana in any combination of colors.