Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Tree of Redemption

Defender
{T}: Exchange your life total with Tree of Redemption's toughness.

Ethereal Haze

Prevent all damage that would be dealt by creatures this turn.

Greater Auramancy

Other enchantments you control have shroud. (A permanent with shroud can't be the target of spells or abilities.)
Enchanted creatures you control have shroud.

Swerve

Change the target of target spell with a single target.

Exquisite Archangel

Flying
If you would lose the game, instead exile Exquisite Archangel and your life total becomes equal to your starting life total.

Confusion in the Ranks

Whenever an artifact, creature, or enchantment enters, its controller chooses target permanent another player controls that shares a card type with it. Exchange control of those permanents.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Pristine Talisman

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Orbs of Warding

You have hexproof. (You can't be the target of spells or abilities your opponents control.)
If a creature would deal damage to you, prevent 1 of that damage.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Plague Reaver

At the beginning of your end step, sacrifice each other creature you control.
Discard two cards, Sacrifice Plague Reaver: Choose target opponent. Return Plague Reaver to the battlefield under that player's control at the beginning of their next upkeep.

Eternity Vessel

Eternity Vessel enters with X charge counters on it, where X is your life total.
Landfall — Whenever a land you control enters, you may have your life total become the number of charge counters on Eternity Vessel.

Angelic Enforcer

Flying
You have hexproof.
Angelic Enforcer's power and toughness are each equal to your life total.
Whenever Angelic Enforcer attacks, double your life total.

Enduring Angel

Flying, double strike
You have hexproof.
If your life total would be reduced to 0 or less, instead transform Enduring Angel and your life total becomes 3. Then if Enduring Angel didn't transform this way, you lose the game.

Enduring Angel // Angelic Enforcer

Skirge Familiar

Final Fortune

Take an extra turn after this one. At the beginning of that turn's end step, you lose the game.

Lich's Mirror

If you would lose the game, instead shuffle your hand, your graveyard, and all permanents you own into your library, then draw seven cards and your life total becomes 20.

Demonic Pact

At the beginning of your upkeep, choose one that hasn't been chosen —
• This enchantment deals 4 damage to any target and you gain 4 life.
• Target opponent discards two cards.
• Draw two cards.
• You lose the game.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Hallow

Prevent all damage target spell would deal this turn. You gain life equal to the damage prevented this way.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Force Bubble

If damage would be dealt to you, put that many depletion counters on Force Bubble instead.
When there are four or more depletion counters on Force Bubble, sacrifice it.
At the beginning of each end step, remove all depletion counters from Force Bubble.

Circle of Protection: White

{1}: The next time a white source of your choice would deal damage to you this turn, prevent that damage.

Kalemne's Captain

Vigilance
{5}{W}{W}: Monstrosity 3. (If this creature isn't monstrous, put three +1/+1 counters on it and it becomes monstrous.)
When Kalemne's Captain becomes monstrous, exile all artifacts and enchantments.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Harmless Offering

Target opponent gains control of target permanent you control.

Yukora, the Prisoner

When Yukora, the Prisoner leaves the battlefield, sacrifice all non-Ogre creatures you control.

Energy Field

Prevent all damage that would be dealt to you by sources you don't control.
When a card is put into your graveyard from anywhere, sacrifice Energy Field.

Circle of Protection: Green

{1}: The next time a green source of your choice would deal damage to you this turn, prevent that damage.

Teysa, Orzhov Scion

Sacrifice three white creatures: Exile target creature.
Whenever another black creature you control dies, create a 1/1 white Spirit creature token with flying.

Sunset Revelry

If an opponent has more life than you, you gain 4 life.
If an opponent controls more creatures than you, create two 1/1 white Human creature tokens.
If an opponent has more cards in hand than you, draw a card.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

The Eternal Wanderer

No more than one creature can attack The Eternal Wanderer each combat.
+1: Exile up to one target artifact or creature. Return that card to the battlefield under its owner's control at the beginning of that player's next end step.
0: Create a 2/2 white Samurai creature token with double strike.
−4: For each player, choose a creature that player controls. Each player sacrifices all creatures they control not chosen this way.

Kokusho, the Evening Star

Flying
When Kokusho, the Evening Star dies, each opponent loses 5 life. You gain life equal to the life lost this way.

Circle of Protection: Blue

{1}: The next time a blue source of your choice would deal damage to you this turn, prevent that damage.

Circle of Protection: Artifacts

{2}: The next time an artifact source of your choice would deal damage to you this turn, prevent that damage.

Dromar's Charm

Choose one —
• You gain 5 life.
• Counter target spell.
• Target creature gets -2/-2 until end of turn.

Consulate Crackdown

When Consulate Crackdown enters, exile all artifacts your opponents control until Consulate Crackdown leaves the battlefield.

Transcendence

You don't lose the game for having 0 or less life.
When you have 20 or more life, you lose the game.
Whenever you lose life, you gain 2 life for each 1 life you lost. (Damage dealt to you causes you to lose life.)

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Solitary Confinement

At the beginning of your upkeep, sacrifice Solitary Confinement unless you discard a card.
Skip your draw step.
You have shroud. (You can't be the target of spells or abilities.)
Prevent all damage that would be dealt to you.

Gideon of the Trials

+1: Until your next turn, prevent all damage target permanent would deal.
0: Until end of turn, Gideon of the Trials becomes a 4/4 Human Soldier creature with indestructible that's still a planeswalker. Prevent all damage that would be dealt to him this turn.
0: You get an emblem with "As long as you control a Gideon planeswalker, you can't lose the game and your opponents can't win the game."

Oko, Thief of Crowns

+2: Create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")
+1: Target artifact or creature loses all abilities and becomes a green Elk creature with base power and toughness 3/3.
−5: Exchange control of target artifact or creature you control and target creature an opponent controls with power 3 or less.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Tamiyo's Safekeeping

Target permanent you control gains hexproof and indestructible until end of turn. You gain 2 life. (A permanent with hexproof and indestructible can't be the target of spells or abilities your opponents control. Damage and effects that say "destroy" don't destroy it.)

Donate

Target player gains control of target permanent you control.

Shabraz, the Skyshark

Partner with Brallin, Skyshark Rider
Flying
Whenever you draw a card, put a +1/+1 counter on Shabraz, the Skyshark and you gain 1 life.
{W/U}: Target Human gains flying until end of turn.

Angel of Suffering

Flying
If damage would be dealt to you, prevent that damage and mill twice that many cards.

Delaying Shield

If damage would be dealt to you, put that many delay counters on Delaying Shield instead.
At the beginning of your upkeep, remove all delay counters from Delaying Shield. For each delay counter removed this way, you lose 1 life unless you pay {1}{W}.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Vigilant Martyr

Sacrifice Vigilant Martyr: Regenerate target creature.
{W}{W}, {T}, Sacrifice Vigilant Martyr: Counter target spell that targets an enchantment.

Surge of Salvation

You and permanents you control gain hexproof until end of turn. Prevent all damage that black and/or red sources would deal to creatures you control this turn.

Doomsday

Search your library and graveyard for five cards and exile the rest. Put the chosen cards on top of your library in any order. You lose half your life, rounded up.

Pay No Heed

Prevent all damage a source of your choice would deal this turn.

Reroute

Change the target of target activated ability with a single target. (Mana abilities can't be targeted.)
Draw a card.

Raised by Giants

Commander creatures you own have base power and toughness 10/10 and are Giants in addition to their other types.

Queza, Augur of Agonies

Whenever you draw a card, target opponent loses 1 life and you gain 1 life.

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Furnace Dragon

Affinity for artifacts (This spell costs {1} less to cast for each artifact you control.)
Flying
When Furnace Dragon enters, if you cast it from your hand, exile all artifacts.

Decree of Annihilation

Exile all artifacts, creatures, and lands from the battlefield, all cards from all graveyards, and all cards from all hands.
Cycling {5}{R}{R} ({5}{R}{R}, Discard this card: Draw a card.)
When you cycle Decree of Annihilation, destroy all lands.

Lich

As Lich enters, you lose life equal to your life total.
You don't lose the game for having 0 or less life.
If you would gain life, draw that many cards instead.
Whenever you're dealt damage, sacrifice that many nontoken permanents. If you can't, you lose the game.
When Lich is put into a graveyard from the battlefield, you lose the game.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Shadow of Mortality

If your life total is less than your starting life total, this spell costs {X} less to cast, where X is the difference.

Nefarious Lich

If damage would be dealt to you, exile that many cards from your graveyard instead. If you can't, you lose the game.
If you would gain life, draw that many cards instead.
When Nefarious Lich leaves the battlefield, you lose the game.

Ertai, Wizard Adept

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Children of Korlis

Sacrifice Children of Korlis: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

All Is Dust

Each player sacrifices all permanents they control that are one or more colors.

Invincible Hymn

Count the number of cards in your library. Your life total becomes that number.

Ormendahl, Profane Prince

Westvale Abbey

{T}: Add {C}.
{5}, {T}, Pay 1 life: Create a 1/1 white and black Human Cleric creature token.
{5}, {T}, Sacrifice five creatures: Transform Westvale Abbey, then untap it.

Westvale Abbey // Ormendahl, Profane Prince

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Circle of Protection: Red

{1}: The next time a red source of your choice would deal damage to you this turn, prevent that damage.

Circle of Protection: Black

{1}: The next time a black source of your choice would deal damage to you this turn, prevent that damage.

Immortal Coil

{T}, Exile two cards from your graveyard: Draw a card.
If damage would be dealt to you, prevent that damage. Exile a card from your graveyard for each 1 damage prevented this way.
When there are no cards in your graveyard, you lose the game.