Serum Visions

Consider

Surveil 1. (Look at the top card of your library. You may put it into your graveyard.)
Draw a card.

High Tide

Until end of turn, whenever a player taps an Island for mana, that player adds an additional {U}.

Gravebreaker Lamia

Lifelink
When Gravebreaker Lamia enters, search your library for a card, put it into your graveyard, then shuffle.
Spells you cast from your graveyard cost {1} less to cast.

Scion of Halaster

Commander creatures you own have "The first time you would draw a card each turn, instead look at the top two cards of your library. Put one of them into your graveyard and the other back on top of your library. Then draw a card."

Secrets of the Dead

Whenever you cast a spell from your graveyard, draw a card.

Preordain

Scry 2, then draw a card. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Talrand, Sky Summoner

Whenever you cast an instant or sorcery spell, create a 2/2 blue Drake creature token with flying.

Vraska's Fall

Each opponent sacrifices a creature or planeswalker of their choice and gets a poison counter.

Otherworldly Gaze

Surveil 3. (Look at the top three cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)
Flashback {1}{U} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Counterspell

Thought Scour

Target player mills two cards.
Draw a card.

Solve the Equation

Search your library for an instant or sorcery card, reveal it, put it into your hand, then shuffle.

Arcane Denial

Counter target spell. Its controller may draw up to two cards at the beginning of the next turn's upkeep.
You draw a card at the beginning of the next turn's upkeep.

You Find the Villains' Lair

Choose one —
• Foil Their Scheme — Counter target spell.
• Learn Their Secrets — Draw two cards, then discard two cards.

Negate

Vohar, Vodalian Desecrator

{T}: Draw a card, then discard a card. If you discarded an instant or sorcery card this way, each opponent loses 1 life and you gain 1 life.
{2}, Sacrifice Vohar, Vodalian Desecrator: You may cast target instant or sorcery card from your graveyard this turn. If that spell would be put into your graveyard, exile it instead. Activate only as a sorcery.

Ponder

Look at the top three cards of your library, then put them back in any order. You may shuffle.
Draw a card.

Doom Blade

Frantic Search

Draw two cards, then discard two cards. Untap up to three lands.

Mercurial Spelldancer

Mercurial Spelldancer can't be blocked.
Whenever you cast a noncreature spell, put an oil counter on Mercurial Spelldancer.
Whenever Mercurial Spelldancer deals combat damage to a player, you may remove two oil counters from it. If you do, when you next cast an instant or sorcery spell this turn, copy that spell. You may choose new targets for the copy.

Wavebreak Hippocamp

Whenever you cast your first spell during each opponent's turn, draw a card.

Cabal Ritual

Add {B}{B}{B}.
Threshold — Add {B}{B}{B}{B}{B} instead if seven or more cards are in your graveyard.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Notion Thief

Flash
If an opponent would draw a card except the first one they draw in each of their draw steps, instead that player skips that draw and you draw a card.

Doomsday

Search your library and graveyard for five cards and exile the rest. Put the chosen cards on top of your library in any order. You lose half your life, rounded up.

Leyline of Anticipation

If Leyline of Anticipation is in your opening hand, you may begin the game with it on the battlefield.
You may cast spells as though they had flash.

Infectious Inquiry

You draw two cards and you lose 2 life. Each opponent gets a poison counter.

Gitaxian Probe

({U/P} can be paid with either {U} or 2 life.)
Look at target player's hand.
Draw a card.

Gale, Waterdeep Prodigy

Whenever you cast an instant or sorcery spell from your hand, you may cast up to one target card of the other type from your graveyard. If a spell cast from your graveyard this way would be put into your graveyard, exile it instead.
Choose a Background (You can have a Background as a second commander.)