Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Dark Intimations

Each opponent sacrifices a creature or planeswalker, then discards a card. You return a creature or planeswalker card from your graveyard to your hand, then draw a card.
When you cast a Bolas planeswalker spell, exile Dark Intimations from your graveyard. That planeswalker enters the battlefield with an additional loyalty counter on it.

Nicol Bolas, the Arisen

+2: Draw two cards.
−3: Nicol Bolas, the Arisen deals 10 damage to target creature or planeswalker.
−4: Put target creature or planeswalker card from a graveyard onto the battlefield under your control.
−12: Exile all but the bottom card of target player's library.

Nicol Bolas, the Ravager

Flying
When Nicol Bolas, the Ravager enters the battlefield, each opponent discards a card.
{4}{U}{B}{R}: Exile Nicol Bolas, the Ravager, then return him to the battlefield transformed under his owner's control. Activate only as a sorcery.

Nicol Bolas, the Ravager // Nicol Bolas, the Arisen

Kroxa, Titan of Death's Hunger

When Kroxa enters the battlefield, sacrifice it unless it escaped.
Whenever Kroxa enters the battlefield or attacks, each opponent discards a card, then each opponent who didn't discard a nonland card this way loses 3 life.
Escape—{B}{B}{R}{R}, Exile five other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)

Burglar Rat

When Burglar Rat enters the battlefield, each opponent discards a card.

Skull Rend

Skull Rend deals 2 damage to each opponent. Those players each discard two cards at random.

Elder Mastery

Enchant creature
Enchanted creature gets +3/+3 and has flying.
Whenever enchanted creature deals damage to a player, that player discards two cards.

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Tinybones, Trinket Thief

At the beginning of each end step, if an opponent discarded a card this turn, you draw a card and you lose 1 life.
{4}{B}{B}: Each opponent with no cards in hand loses 10 life.

Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Cult Guildmage

{3}{B}, {T}: Target player discards a card. Activate only as a sorcery.
{R}, {T}: Cult Guildmage deals 1 damage to target opponent or planeswalker.

Cao Cao, Lord of Wei

{T}: Target opponent discards two cards. Activate only during your turn, before attackers are declared.

Words of Waste

{1}: The next time you would draw a card this turn, each opponent discards a card instead.

Guul Draz Specter

Flying
Guul Draz Specter gets +3/+3 as long as an opponent has no cards in hand.
Whenever Guul Draz Specter deals combat damage to a player, that player discards a card.

Scythe Specter

Flying
Whenever Scythe Specter deals combat damage to a player, each opponent discards a card. Each player who discarded a card with the highest mana value among cards discarded this way loses life equal to that mana value.

Stabwhisker the Odious

At the beginning of each opponent's upkeep, that player loses 1 life for each card fewer than three in their hand.

Nezumi Shortfang

{1}{B}, {T}: Target opponent discards a card. Then if that player has no cards in hand, flip Nezumi Shortfang.

Nezumi Shortfang // Stabwhisker the Odious

Rankle's Prank

Choose one or more —
• Each player discards two cards.
• Each player loses 4 life.
• Each player sacrifices two creatures.

Hopeless Nightmare

When Hopeless Nightmare enters the battlefield, each opponent discards a card and loses 2 life.
When Hopeless Nightmare is put into a graveyard from the battlefield, scry 2.
{2}{B}: Sacrifice Hopeless Nightmare.

Dusk Mangler

As an additional cost to cast this spell, sacrifice a creature, discard a card, or pay 4 life.
When Dusk Mangler enters the battlefield, each opponent sacrifices a creature, discards a card, and loses 4 life.

The Raven Man

At the beginning of each end step, if a player discarded a card this turn, create a 1/1 black Bird creature token with flying and "This creature can't block."
{3}{B}, {T}: Each opponent discards a card. Activate only as a sorcery.

Oblivion

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Target opponent discards two cards.

Consign

Return target nonland permanent to its owner's hand.

Consign // Oblivion

Dispersal

Each opponent returns a nonland permanent they control with the highest mana value among permanents they control to its owner's hand, then discards a card.

Discovery

Surveil 2, then draw a card. (To surveil 2, look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Discovery // Dispersal

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Skullslither Worm

When Skullslither Worm enters the battlefield, each opponent discards a card. For each opponent who can't, put two +1/+1 counters on Skullslither Worm.

Dream Salvage

Draw cards equal to the number of cards target opponent discarded this turn.

The True Scriptures

(As this Saga enters and after your draw step, add a lore counter.)
I — For each opponent, destroy up to one target creature or planeswalker that player controls.
II — Each opponent discards three cards, then mills three cards.
III — Put all creature cards from all graveyards onto the battlefield under your control. Exile The True Scriptures, then return it to the battlefield (front face up).

Sheoldred

Menace
When Sheoldred enters the battlefield, each opponent sacrifices a nontoken creature or planeswalker.
{4}{B}: Exile Sheoldred, then return it to the battlefield transformed under its owner's control. Activate only as a sorcery and only if an opponent has eight or more cards in their graveyard.

Sheoldred // The True Scriptures

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Cruel Ultimatum

Target opponent sacrifices a creature, discards three cards, then loses 5 life. You return a creature card from your graveyard to your hand, draw three cards, then gain 5 life.

Court of Ambition

When Court of Ambition enters the battlefield, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Pain Magnification

Whenever an opponent is dealt 3 or more damage by a single source, that player discards a card.

Sedraxis Specter

Flying
Whenever Sedraxis Specter deals combat damage to a player, that player discards a card.
Unearth {1}{B} ({1}{B}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Cunning Advisor

{T}: Target opponent discards a card. Activate only during your turn, before attackers are declared.

Tasigur's Cruelty

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)
Each opponent discards two cards.

Elderfang Disciple

When Elderfang Disciple enters the battlefield, each opponent discards a card.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Nezumi Informant

When Nezumi Informant enters the battlefield, each opponent discards a card.

Virus Beetle

When Virus Beetle enters the battlefield, each opponent discards a card.

Davriel, Rogue Shadowmage

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, Davriel, Rogue Shadowmage deals 2 damage to them.
−1: Target player discards a card.

Brainbite

Target opponent reveals their hand. You choose a card from it. That player discards that card.
Draw a card.

Prickle Faeries

Flying
At the beginning of each opponent's upkeep, if that player has two or fewer cards in hand, Prickle Faeries deals 2 damage to them.

Invasion of Eldraine

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Eldraine enters the battlefield, target opponent discards two cards.

Invasion of Eldraine // Prickle Faeries

Mindculling

You draw two cards and target opponent discards two cards.

Siren of the Silent Song

Flying
Inspired — Whenever Siren of the Silent Song becomes untapped, each opponent discards a card, then each opponent mills a card.

Lazotep Convert

You may have Lazotep Convert enter the battlefield as a copy of any creature card in a graveyard, except it's a 4/4 black Zombie in addition to its other colors and types.

Invasion of Amonkhet

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Amonkhet enters the battlefield, each player mills three cards, then each opponent discards a card and you draw a card. (To mill three cards, a player puts the top three cards of their library into their graveyard.)

Invasion of Amonkhet // Lazotep Convert

Fell Specter

Flying
When Fell Specter enters the battlefield, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Phyrexian Espionage

Kicker {1}{B} (You may pay an additional {1}{B} as you cast this spell.)
Draw two cards. If this spell was kicked, each opponent discards a card.