Citywide Bust

Destroy all creatures with toughness 4 or greater.

Bend or Break

Each player separates all nontoken lands they control into two piles. For each player, one of their piles is chosen by one of their opponents of their choice. Destroy all lands in the chosen piles. Tap all lands in the other piles.

Devastation

Fight to the Death

Destroy all blocking creatures and all blocked creatures.

Strip Bare

Destroy all Auras and Equipment attached to target creature.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Tranquil Domain

Planar Cleansing

Fated Retribution

Destroy all creatures and planeswalkers. If it's your turn, scry 2.

Fade from History

Each player who controls an artifact or enchantment creates a 2/2 green Bear creature token. Then destroy all artifacts and enchantments.

Purify

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

The Phasing of Zhalfir

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I, II — Another target nonland permanent phases out. It can't phase in for as long as you control The Phasing of Zhalfir.
III — Destroy all creatures. For each creature destroyed this way, its controller creates a 2/2 black Phyrexian creature token.

Shatterstorm

Destroy all artifacts. They can't be regenerated.

Force of Despair

If it's not your turn, you may exile a black card from your hand rather than pay this spell's mana cost.
Destroy all creatures that entered this turn.

Day of Judgment

Spring Cleaning

Destroy target enchantment. Clash with an opponent. If you win, destroy all enchantments your opponents control. (Each clashing player reveals the top card of their library, then puts that card on the top or bottom. A player wins if their card had a higher mana value.)

Rampage of the Clans

Destroy all artifacts and enchantments. For each permanent destroyed this way, its controller creates a 3/3 green Centaur creature token.

Fracturing Gust

Destroy all artifacts and enchantments. You gain 2 life for each permanent destroyed this way.

Tranquil Grove

{1}{G}{G}: Destroy all other enchantments.

Total War

Whenever a player attacks with one or more creatures, destroy all untapped non-Wall creatures that player controls that didn't attack, except for creatures the player hasn't controlled continuously since the beginning of the turn.

Obliterate

This spell can't be countered.
Destroy all artifacts, creatures, and lands. They can't be regenerated.

Corrosive Ooze

Whenever Corrosive Ooze blocks or becomes blocked by an equipped creature, destroy all Equipment attached to that creature at end of combat.

Tranquility

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Bearer of the Heavens

When Bearer of the Heavens dies, destroy all permanents at the beginning of the next end step.

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Void

Choose a number. Destroy all artifacts and creatures with mana value equal to that number. Then target player reveals their hand and discards all nonland cards with mana value equal to the number.

Primeval Light

Destroy all enchantments target player controls.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Fell the Mighty

Destroy all creatures with power greater than target creature's power.

Tempest of Light

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Retaliate

Destroy all creatures that dealt damage to you this turn.

Armageddon

Back to Nature

Sunblast Angel

Flying
When Sunblast Angel enters, destroy all tapped creatures.

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Turn to Slag

Turn to Slag deals 5 damage to target creature. Destroy all Equipment attached to that creature.

Damnation

Destroy all creatures. They can't be regenerated.

Brotherhood's End

Choose one —
• Brotherhood's End deals 3 damage to each creature and each planeswalker.
• Destroy all artifacts with mana value 3 or less.

Decree of Annihilation

Exile all artifacts, creatures, and lands from the battlefield, all cards from all graveyards, and all cards from all hands.
Cycling {5}{R}{R} ({5}{R}{R}, Discard this card: Draw a card.)
When you cycle Decree of Annihilation, destroy all lands.

Planar Collapse

At the beginning of your upkeep, if there are four or more creatures on the battlefield, sacrifice Planar Collapse and destroy all creatures. They can't be regenerated.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Puppet's Verdict

Flip a coin. If you win the flip, destroy all creatures with power 2 or less. If you lose the flip, destroy all creatures with power 3 or greater.

Coercive Portal

Will of the council — At the beginning of your upkeep, starting with you, each player votes for carnage or homage. If carnage gets more votes, sacrifice Coercive Portal and destroy all nonland permanents. If homage gets more votes or the vote is tied, draw a card.

Calming Verse

Destroy all enchantments you don't control. Then if you control an untapped land, destroy all enchantments you control.

Extinguish All Hope

Impending Disaster

At the beginning of your upkeep, if there are seven or more lands on the battlefield, sacrifice Impending Disaster and destroy all lands.

Serenity

At the beginning of your upkeep, destroy all artifacts and enchantments. They can't be regenerated.

Do or Die

Separate all creatures target player controls into two piles. Destroy all creatures in the pile of that player's choice. They can't be regenerated.

Jokulhaups

Destroy all artifacts, creatures, and lands. They can't be regenerated.

Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Path of Peril

Cleave {4}{W}{B} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Destroy all creatures [with mana value 2 or less].

Celestial Kirin

Flying
Whenever you cast a Spirit or Arcane spell, destroy all permanents with that spell's mana value.

Ruination

Blood Money

Destroy all creatures. For each nontoken creature destroyed this way, you create a tapped Treasure token.

Bane of Progress

When Bane of Progress enters, destroy all artifacts and enchantments. Put a +1/+1 counter on Bane of Progress for each permanent destroyed this way.

Worldslayer

Whenever equipped creature deals combat damage to a player, destroy all permanents other than Worldslayer.
Equip {5} ({5}: Attach to target creature you control. Equip only as a sorcery.)

Wrath of God

Scourglass

{T}, Sacrifice Scourglass: Destroy all permanents except for artifacts and lands. Activate only during your upkeep.

Child of Alara

Trample
When Child of Alara dies, destroy all nonland permanents. They can't be regenerated.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Breaking Point

Any player may have Breaking Point deal 6 damage to them. If no one does, destroy all creatures. Creatures destroyed this way can't be regenerated.