Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Plunge into Darkness

Choose one —
• Sacrifice any number of creatures. You gain 3 life for each creature sacrificed this way.
• Pay any amount of life, then look at that many cards from the top of your library. Put one of those cards into your hand and exile the rest.
Entwine {B} (Choose both if you pay the entwine cost.)

Mana Tithe

Counter target spell unless its controller pays {1}.

Worship

If you control a creature, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Weathered Wayfarer

{W}, {T}: Search your library for a land card, reveal it, put it into your hand, then shuffle. Activate only if an opponent controls more lands than you.

Rhox Faithmender

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
If you would gain life, you gain twice that much life instead.

Hex Parasite

{X}{B/P}: Remove up to X counters from target permanent. For each counter removed this way, Hex Parasite gets +1/+0 until end of turn. ({B/P} can be paid with either {B} or 2 life.)

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Wishclaw Talisman

Wishclaw Talisman enters with three wish counters on it.
{1}, {T}, Remove a wish counter from Wishclaw Talisman: Search your library for a card, put it into your hand, then shuffle. An opponent gains control of Wishclaw Talisman. Activate only during your turn.

The Book of Exalted Deeds

At the beginning of your end step, if you gained 3 or more life this turn, create a 3/3 white Angel creature token with flying.
{W}{W}{W}, {T}, Exile The Book of Exalted Deeds: Put an enlightened counter on target Angel. It gains "You can't lose the game and your opponents can't win the game." Activate only as a sorcery.

Approach of the Second Sun

If this spell was cast from your hand and you've cast another spell named Approach of the Second Sun this game, you win the game. Otherwise, put Approach of the Second Sun into its owner's library seventh from the top and you gain 7 life.

Phyrexian Processor

As Phyrexian Processor enters, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as Phyrexian Processor entered.

Resolute Archangel

Flying
When Resolute Archangel enters, if your life total is less than your starting life total, it becomes equal to your starting life total.

Angel of Grace

Flash
Flying
When Angel of Grace enters, until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.
{4}{W}{W}, Exile Angel of Grace from your graveyard: Your life total becomes 10.

Snuff Out

If you control a Swamp, you may pay 4 life rather than pay this spell's mana cost.
Destroy target nonblack creature. It can't be regenerated.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Dark Ritual

Netherborn Phalanx

When Netherborn Phalanx enters, each opponent loses 1 life for each creature they control.
Transmute {1}{B}{B} ({1}{B}{B}, Discard this card: Search your library for a card with the same mana value as this card, reveal it, put it into your hand, then then shuffle. Transmute only as a sorcery.)

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Open the Vaults

Return all artifact and enchantment cards from all graveyards to the battlefield under their owners' control. (Auras with nothing to enchant remain in graveyards.)

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Greed

Tainted Sigil

{T}, Sacrifice Tainted Sigil: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Myrel, Shield of Argive

During your turn, your opponents can't cast spells or activate abilities of artifacts, creatures, or enchantments.
Whenever Myrel, Shield of Argive attacks, create X 1/1 colorless Soldier artifact creature tokens, where X is the number of Soldiers you control.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Selenia, Dark Angel

Flying
Pay 2 life: Return Selenia, Dark Angel to its owner's hand.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is Esper Sentinel's power.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Doom Whisperer

Flying, trample
Pay 2 life: Surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Infernal Grasp

Destroy target creature. You lose 2 life.

Cloudsteel Kirin

Flying
Equipped creature has flying and "You can't lose the game and your opponents can't win the game."
Reconfigure {5} ({5}: Attach to target creature you control; or unattach from a creature. Reconfigure only as a sorcery. While attached, this isn't a creature.)

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Eternity Vessel

Eternity Vessel enters with X charge counters on it, where X is your life total.
Landfall — Whenever a land you control enters, you may have your life total become the number of charge counters on Eternity Vessel.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Tragic Arrogance

For each player, you choose from among the permanents that player controls an artifact, a creature, an enchantment, and a planeswalker. Then each player sacrifices all other nonland permanents they control.

Exquisite Archangel

Flying
If you would lose the game, instead exile Exquisite Archangel and your life total becomes equal to your starting life total.

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Vanishing Verse

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Dark Tutelage

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Solemnity

Players can't get counters.
Counters can't be put on artifacts, creatures, enchantments, or lands.

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Intervention Pact

The next time a source of your choice would deal damage to you this turn, prevent that damage. You gain life equal to the damage prevented this way.
At the beginning of your next upkeep, pay {1}{W}{W}. If you don't, you lose the game.

Angelic Enforcer

Flying
You have hexproof.
Angelic Enforcer's power and toughness are each equal to your life total.
Whenever Angelic Enforcer attacks, double your life total.

Enduring Angel

Flying, double strike
You have hexproof.
If your life total would be reduced to 0 or less, instead transform Enduring Angel and your life total becomes 3. Then if Enduring Angel didn't transform this way, you lose the game.

Enduring Angel // Angelic Enforcer

Evra, Halcyon Witness

Lifelink
{4}: Exchange your life total with Evra, Halcyon Witness's power.

Rebuff the Wicked

Counter target spell that targets a permanent you control.

Surge of Salvation

You and permanents you control gain hexproof until end of turn. Prevent all damage that black and/or red sources would deal to creatures you control this turn.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Grand Abolisher

During your turn, your opponents can't cast spells or activate abilities of artifacts, creatures, or enchantments.

Felidar Sovereign

Vigilance, lifelink
At the beginning of your upkeep, if you have 40 or more life, you win the game.

Dark Confidant

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Excise the Imperfect

Exile target nonland permanent. Its controller incubates X, where X is its mana value. (They create an Incubator token with X +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Angel of Destiny

Flying, double strike
Whenever a creature you control deals combat damage to a player, you and that player each gain that much life.
At the beginning of your end step, if you have at least 15 life more than your starting life total, each player Angel of Destiny attacked this turn loses the game.

Idyllic Tutor

Search your library for an enchantment card, reveal it, put it into your hand, then shuffle.

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Soul Echo

Soul Echo enters with X echo counters on it.
You don't lose the game for having 0 or less life.
At the beginning of your upkeep, sacrifice Soul Echo if there are no echo counters on it. Otherwise, target opponent may choose that for each 1 damage that would be dealt to you until your next upkeep, you remove an echo counter from Soul Echo instead.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Children of Korlis

Sacrifice Children of Korlis: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

Plague Drone

Flying
Rot Fly — If an opponent would gain life, that player loses that much life instead.

Fracture

Destroy target artifact, enchantment, or planeswalker.

Solemn Simulacrum

When Solemn Simulacrum enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When Solemn Simulacrum dies, you may draw a card.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Sign in Blood

Target player draws two cards and loses 2 life.