Fateful Absence

Destroy target creature or planeswalker. Its controller investigates. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Unmake

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Indestructibility

Enchant permanent
Enchanted permanent has indestructible. (Effects that say "destroy" don't destroy that permanent. A creature with indestructible can't be destroyed by damage.)

Cut Down

Destroy target creature with total power and toughness 5 or less.

Infernal Grasp

Destroy target creature. You lose 2 life.

Platinum Emperion

Your life total can't change. (You can't gain or lose life. You can't pay any amount of life except 0.)

Dark Ritual

Fountain Watch

Artifacts and enchantments you control have shroud. (They can't be the targets of spells or abilities.)