Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Infectious Inquiry

You draw two cards and you lose 2 life. Each opponent gets a poison counter.

Veinwitch Coven

Menace
Whenever you gain life, you may pay {B}. If you do, return target creature card from your graveyard to your hand.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: This artifact deals 50 damage to any target.

Damnable Pact

Target player draws X cards and loses X life.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Creeping Bloodsucker

At the beginning of your upkeep, this creature deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Price of Knowledge

Players have no maximum hand size.
At the beginning of each opponent's upkeep, this enchantment deals damage to that player equal to the number of cards in that player's hand.

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Howling Mine

At the beginning of each player's draw step, if this artifact is untapped, that player draws an additional card.

Sign in Blood

Target player draws two cards and loses 2 life.

Temporal Extortion

When you cast this spell, any player may pay half their life, rounded up. If a player does, counter Temporal Extortion.
Take an extra turn after this one.

Baleful Mastery

You may pay {1}{B} rather than pay this spell's mana cost.
If the {1}{B} cost was paid, an opponent draws a card.
Exile target creature or planeswalker.

Fate Unraveler

Whenever an opponent draws a card, this creature deals 1 damage to that player.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Painful Lesson

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Night's Whisper

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Gruesome Realization

Choose one —
• You draw two cards and you lose 2 life.
• Creatures your opponents control get -1/-1 until end of turn.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Horn of Greed

Whenever a player plays a land, that player draws a card.

Venser's Journal

You have no maximum hand size.
At the beginning of your upkeep, you gain 1 life for each card in your hand.

Mikokoro, Center of the Sea

{T}: Add {C}.
{2}, {T}: Each player draws a card.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Sol Ring

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle this card, all creatures get -2/-2 until end of turn.

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When this creature dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Font of Mythos

At the beginning of each player's draw step, that player draws two additional cards.

Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Temple Bell

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Otherworld Atlas

{T}: Put a charge counter on this artifact.
{T}: Each player draws a card for each charge counter on this artifact.

Blood Pact

Sickening Dreams

As an additional cost to cast this spell, discard X cards.
Sickening Dreams deals X damage to each creature and each player.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• This creature deals 2 damage to any target and you gain 2 life.

Underworld Dreams

Whenever an opponent draws a card, this enchantment deals 1 damage to that player.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Foreboding Fruit

Target player draws two cards and loses 2 life.
Adamant — If at least three black mana was spent to cast this spell, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Reliquary Tower

Iron Maiden

At the beginning of each opponent's upkeep, this artifact deals X damage to that player, where X is the number of cards in their hand minus 4.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on this creature.

Dark Ritual

Howling Golem

Whenever this creature attacks or blocks, each player draws a card.

Succumb to Temptation

Hero's Downfall

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.