Feed the Infection

You draw three cards and you lose 3 life.
Corrupted — Each opponent who has three or more poison counters loses 3 life.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Don't Have

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Crawlspace

No more than two creatures can attack you each combat.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Tivash, Gloom Summoner

Lifelink
At the beginning of your end step, if you gained life this turn, you may pay X life, where X is the amount of life you gained this turn. If you do, create an X/X black Demon creature token with flying.

Phyrexian Reclamation

{1}{B}, Pay 2 life: Return target creature card from your graveyard to your hand.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Phyrexian Obliterator

Trample
Whenever a source deals damage to Phyrexian Obliterator, that source's controller sacrifices that many permanents of their choice.

Hero's Downfall

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Elder Brain

Menace
Whenever Elder Brain attacks a player, exile all cards from that player's hand, then they draw that many cards. You may play lands and cast spells from among the exiled cards for as long as they remain exiled. If you cast a spell this way, you may spend mana as though it were mana of any color to cast it.

Fell Stinger

Deathtouch
Exploit (When this creature enters, you may sacrifice a creature.)
When Fell Stinger exploits a creature, target player draws two cards and loses 2 life.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Nightmare Shepherd

Flying
Whenever another nontoken creature you control dies, you may exile it. If you do, create a token that's a copy of that creature, except it's 1/1 and it's a Nightmare in addition to its other types.

Greed

Blessing of Leeches

Flash
Enchant creature
At the beginning of your upkeep, you lose 1 life.
{0}: Regenerate enchanted creature.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

hard

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Silent Arbiter

No more than one creature can attack each combat.
No more than one creature can block each combat.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Massacre Wurm

When this creature enters, creatures your opponents control get -2/-2 until end of turn.
Whenever a creature an opponent controls dies, that player loses 2 life.

Stinging Study

You draw X cards and you lose X life, where X is the mana value of a commander you own on the battlefield or in the command zone.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

No Mercy

Whenever a creature deals damage to you, destroy it.

Bloodbond Vampire

Whenever you gain life, put a +1/+1 counter on Bloodbond Vampire.

Mikokoro, Center of the Sea

{T}: Add {C}.
{2}, {T}: Each player draws a card.

Thought Vessel

Howling Mine

At the beginning of each player's draw step, if Howling Mine is untapped, that player draws an additional card.

Coveted Jewel

When Coveted Jewel enters, draw three cards.
{T}: Add three mana of any one color.
Whenever one or more creatures an opponent controls attack you and aren't blocked, that player draws three cards and gains control of Coveted Jewel. Untap it.

Expedition Map

{2}, {T}, Sacrifice this artifact: Search your library for a land card, reveal it, put it into your hand, then shuffle.

Plague of Vermin

Starting with you, each player may pay any amount of life. Repeat this process until no one pays life. Each player creates a 1/1 black Rat creature token for each 1 life they paid this way.

Ancient Craving

You draw three cards and you lose 3 life.

Minion's Return

Flash
Enchant creature
When enchanted creature dies, return that card to the battlefield under your control.

Treacherous Blessing

When Treacherous Blessing enters, draw three cards.
Whenever you cast a spell, you lose 1 life.
When Treacherous Blessing becomes the target of a spell or ability, sacrifice it.

Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Sol Ring

Infectious Inquiry

You draw two cards and you lose 2 life. Each opponent gets a poison counter.

Dark Ritual

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Magus of the Coffers

{2}, {T}: Add {B} for each Swamp you control.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Infernal Grasp

Destroy target creature. You lose 2 life.

Dauthi Voidwalker

Shadow (This creature can block or be blocked by only creatures with shadow.)
If a card would be put into an opponent's graveyard from anywhere, instead exile it with a void counter on it.
{T}, Sacrifice Dauthi Voidwalker: Choose an exiled card an opponent owns with a void counter on it. You may play it this turn without paying its mana cost.

Temple Bell

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Cabal Coffers

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Supernatural Stamina

Until end of turn, target creature gets +2/+0 and gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Ambition's Cost

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Helm of the Host

At the beginning of combat on your turn, create a token that's a copy of equipped creature, except the token isn't legendary. That token gains haste.
Equip {5}

Swamp

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Strands of Undeath

Enchant creature
When Strands of Undeath enters, target player discards two cards.
{B}: Regenerate enchanted creature.

Fake Your Own Death

Until end of turn, target creature gets +2/+0 and gains "When this creature dies, return it to the battlefield tapped under its owner's control and you create a Treasure token." (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Go for the Throat

Ward of Bones

Each opponent who controls more creatures than you can't cast creature spells. The same is true for artifacts and enchantments.
Each opponent who controls more lands than you can't play lands.

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Nirkana Revenant

Whenever you tap a Swamp for mana, add an additional {B}.
{B}: Nirkana Revenant gets +1/+1 until end of turn.

Font of Mythos

At the beginning of each player's draw step, that player draws two additional cards.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Damnable Pact

Target player draws X cards and loses X life.

Night's Whisper

Sensei's Divining Top

{1}: Look at the top three cards of your library, then put them back in any order.
{T}: Draw a card, then put Sensei's Divining Top on top of its owner's library.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Evolved Sleeper

{B}: Evolved Sleeper becomes a Human Cleric with base power and toughness 2/2.
{1}{B}: If Evolved Sleeper is a Cleric, put a deathtouch counter on it and it becomes a Phyrexian Human Cleric with base power and toughness 3/3.
{1}{B}{B}: If Evolved Sleeper is a Phyrexian, put a +1/+1 counter on it, then you draw a card and you lose 1 life.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)