Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Go for the Throat

Tenacious Underdog

Blitz—{2}{B}{B}, Pay 2 life. (If you cast this spell for its blitz cost, it gains haste and "When this creature dies, draw a card." Sacrifice it at the beginning of the next end step.)
You may cast Tenacious Underdog from your graveyard using its blitz ability.

Tymaret, Chosen from Death

Tymaret's toughness is equal to your devotion to black. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
{1}{B}: Exile up to two target cards from graveyards. You gain 1 life for each creature card exiled this way.

Diregraf Ghoul

Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Graf Reaver

Exploit (When this creature enters, you may sacrifice a creature.)
When Graf Reaver exploits a creature, destroy target planeswalker.
At the beginning of your upkeep, Graf Reaver deals 1 damage to you.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Swamp

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Phyrexian Obliterator

Trample
Whenever a source deals damage to Phyrexian Obliterator, that source's controller sacrifices that many permanents of their choice.

Archfiend of the Dross

Flying
Archfiend of the Dross enters with four oil counters on it.
At the beginning of your upkeep, remove an oil counter from Archfiend of the Dross. Then if it has no oil counters on it, you lose the game.
Whenever a creature an opponent controls dies, its controller loses 2 life.

Gutterbones

Gutterbones enters tapped.
{1}{B}: Return Gutterbones from your graveyard to your hand. Activate only during your turn and only if an opponent lost life this turn.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Shakedown Heavy

Menace
Whenever Shakedown Heavy attacks, defending player may have you draw a card. If they do, untap Shakedown Heavy and remove it from combat.

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Misery's Shadow

If a creature an opponent controls would die, exile it instead.
{1}: Misery's Shadow gets +1/+1 until end of turn.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)