Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Plague Spitter

At the beginning of your upkeep, Plague Spitter deals 1 damage to each creature and each player.
When Plague Spitter dies, it deals 1 damage to each creature and each player.

Vial of Poison

{1}, Sacrifice Vial of Poison: Target creature gains deathtouch until end of turn. (Any amount of damage it deals to a creature is enough to destroy it.)

Contagion Engine

When Contagion Engine enters the battlefield, put a -1/-1 counter on each creature target player controls.
{4}, {T}: Proliferate twice. (Choose any number of permanents and/or players, then give each another counter of each kind already there. Then do it again.)

Plague Belcher

Menace
When Plague Belcher enters the battlefield, put two -1/-1 counters on target creature you control.
Whenever another Zombie you control dies, each opponent loses 1 life.

Plaguebearer

{X}{X}{B}: Destroy target nonblack creature with mana value X.

Phage the Untouchable

When Phage the Untouchable enters the battlefield, if you didn't cast it from your hand, you lose the game.
Whenever Phage deals combat damage to a creature, destroy that creature. It can't be regenerated.
Whenever Phage deals combat damage to a player, that player loses the game.

Infest

All creatures get -2/-2 until end of turn.

Contagion Clasp

When Contagion Clasp enters the battlefield, put a -1/-1 counter on target creature.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Infested Roothold

Defender (This creature can't attack.)
Protection from artifacts
Whenever an opponent casts an artifact spell, you may create a 1/1 green Insect creature token.

Engineered Plague

As Engineered Plague enters the battlefield, choose a creature type.
All creatures of the chosen type get -1/-1.

Crown of Doom

Whenever a creature attacks you or a planeswalker you control, it gets +2/+0 until end of turn.
{2}: Target player other than Crown of Doom's owner gains control of it. Activate only during your turn.

Traveling Plague

Enchant creature
At the beginning of each upkeep, put a plague counter on Traveling Plague.
Enchanted creature gets -1/-1 for each plague counter on Traveling Plague.
When enchanted creature leaves the battlefield, that creature's controller returns Traveling Plague from its owner's graveyard to the battlefield.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature, then sacrifices a land.

Oko, Thief of Crowns

+2: Create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")
+1: Target artifact or creature loses all abilities and becomes a green Elk creature with base power and toughness 3/3.
−5: Exchange control of target artifact or creature you control and target creature an opponent controls with power 3 or less.

Necrotic Plague

Enchant creature
Enchanted creature has "At the beginning of your upkeep, sacrifice this creature."
When enchanted creature dies, its controller chooses target creature one of their opponents controls. Return Necrotic Plague from its owner's graveyard to the battlefield attached to that creature.

Infected Vermin

{2}{B}: Infected Vermin deals 1 damage to each creature and each player.
Threshold — {3}{B}: Infected Vermin deals 3 damage to each creature and each player. Activate only if seven or more cards are in your graveyard.

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control, then sacrifices a third of the lands they control. Round up each time.

Plague Witch

{B}, {T}, Discard a card: Target creature gets -1/-1 until end of turn.

Contagion

You may pay 1 life and exile a black card from your hand rather than pay this spell's mana cost.
Distribute two -2/-1 counters among one or two target creatures.

Spreading Plague

Whenever a creature enters the battlefield, destroy all other creatures that share a color with it. They can't be regenerated.

Undercity Plague

Target player loses 1 life, discards a card, then sacrifices a permanent.
Cipher (Then you may exile this spell card encoded on a creature you control. Whenever that creature deals combat damage to a player, its controller may cast a copy of the encoded card without paying its mana cost.)

Trigon of Infestation

Trigon of Infestation enters the battlefield with three charge counters on it.
{G}{G}, {T}: Put a charge counter on Trigon of Infestation.
{2}, {T}, Remove a charge counter from Trigon of Infestation: Create a 1/1 green Phyrexian Insect creature token with infect.

Instill Infection

Put a -1/-1 counter on target creature.
Draw a card.

Crown of Suspicion

Enchant creature
Enchanted creature gets +2/-1.
Sacrifice Crown of Suspicion: Enchanted creature and other creatures that share a creature type with it get +2/-1 until end of turn.

Virulent Plague

The Mimeoplasm

As The Mimeoplasm enters the battlefield, you may exile two creature cards from graveyards. If you do, it enters the battlefield as a copy of one of those cards with a number of additional +1/+1 counters on it equal to the power of the other card.

Plaguecrafter

When Plaguecrafter enters the battlefield, each player sacrifices a creature or planeswalker. Each player who can't discards a card.

Fungal Infection

Target creature gets -1/-1 until end of turn. Create a 1/1 green Saproling creature token.

Phyrexian Plaguelord

{T}, Sacrifice Phyrexian Plaguelord: Target creature gets -4/-4 until end of turn.
Sacrifice a creature: Target creature gets -1/-1 until end of turn.

Oblivion Crown

Flash (You may cast this spell any time you could cast an instant.)
Enchant creature
Enchanted creature has "Discard a card: This creature gets +1/+1 until end of turn."

Hired Poisoner

Hapatra, Vizier of Poisons

Whenever Hapatra, Vizier of Poisons deals combat damage to a player, you may put a -1/-1 counter on target creature.
Whenever you put one or more -1/-1 counters on a creature, create a 1/1 green Snake creature token with deathtouch.

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Mindstorm Crown

At the beginning of your upkeep, draw a card if you had no cards in hand at the beginning of this turn. If you had a card in hand, Mindstorm Crown deals 1 damage to you.

Spread the Sickness

Destroy target creature, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Illness in the Ranks

Swallowing Plague

Swallowing Plague deals X damage to target creature and you gain X life.

Crown of Empires

{3}, {T}: Tap target creature. Gain control of that creature instead if you control artifacts named Scepter of Empires and Throne of Empires.

Infectious Host

When Infectious Host dies, target player loses 2 life.

Plague Engineer

Deathtouch
As Plague Engineer enters the battlefield, choose a creature type.
Creatures of the chosen type your opponents control get -1/-1.

Plague Boiler

At the beginning of your upkeep, put a plague counter on Plague Boiler.
{1}{B}{G}: Put a plague counter on Plague Boiler or remove a plague counter from it.
When Plague Boiler has three or more plague counters on it, sacrifice it. If you do, destroy all nonland permanents.

Pharika, God of Affliction

Indestructible
As long as your devotion to black and green is less than seven, Pharika isn't a creature.
{B}{G}: Exile target creature card from a graveyard. Its owner creates a 1/1 black and green Snake enchantment creature token with deathtouch.

Plague Myr

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{T}: Add {C}.