Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Ajani's Pridemate

Whenever you gain life, put a +1/+1 counter on this creature.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Ajani, Strength of the Pride

+1: You gain life equal to the number of creatures you control plus the number of planeswalkers you control.
−2: Create a 2/2 white Cat Soldier creature token named Ajani's Pridemate with "Whenever you gain life, put a +1/+1 counter on Ajani's Pridemate."
0: If you have at least 15 life more than your starting life total, exile Ajani, Strength of the Pride and each artifact and creature your opponents control.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Vindicate

Archivist of Oghma

Flash
Whenever an opponent searches their library, you gain 1 life and draw a card.

Giver of Runes

{T}: Another target creature you control gains protection from colorless or from the color of your choice until end of turn.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Utter End

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Archangel of Thune

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Whenever you gain life, put a +1/+1 counter on each creature you control.

Kabira Crossroads

Kabira Crossroads enters tapped.
When Kabira Crossroads enters, you gain 2 life.
{T}: Add {W}.

Mother of Runes

{T}: Target creature you control gains protection from the color of your choice until end of turn.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Elas il-Kor, Sadistic Pilgrim

Deathtouch
Whenever another creature you control enters, you gain 1 life.
Whenever another creature you control dies, each opponent loses 1 life.

Fracture

Destroy target artifact, enchantment, or planeswalker.

Crested Sunmare

Other Horses you control have indestructible.
At the beginning of each end step, if you gained life this turn, create a 5/5 white Horse creature token.

Dawn of Hope

Whenever you gain life, you may pay {2}. If you do, draw a card.
{3}{W}: Create a 1/1 white Soldier creature token with lifelink.

Luminous Phantom

Flying
Whenever another creature you control leaves the battlefield, you gain 1 life.
If Luminous Phantom would be put into a graveyard from anywhere, exile it instead.

Lunarch Veteran

Whenever another creature you control enters, you gain 1 life.
Disturb {1}{W} (You may cast this card from your graveyard transformed for its disturb cost.)

Lunarch Veteran // Luminous Phantom

Thought Vessel

Despark

Exile target permanent with mana value 4 or greater.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Mortify

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Sorin, Grim Nemesis

+1: Reveal the top card of your library and put that card into your hand. Each opponent loses life equal to its mana value.
−X: Sorin, Grim Nemesis deals X damage to target creature or planeswalker and you gain X life.
−9: Create a number of 1/1 black Vampire Knight creature tokens with lifelink equal to the highest life total among all players.

Karlov of the Ghost Council

Whenever you gain life, put two +1/+1 counters on Karlov of the Ghost Council.
{W}{B}, Remove six +1/+1 counters from Karlov of the Ghost Council: Exile target creature.

Speaker of the Heavens

Vigilance, lifelink (Attacking doesn't cause this creature to tap. Damage dealt by this creature also causes you to gain that much life.)
{T}: Create a 4/4 white Angel creature token with flying. Activate only if you have at least 7 life more than your starting life total and only as a sorcery.

Nyx-Fleece Ram

At the beginning of your upkeep, you gain 1 life.

Radiant Fountain

When Radiant Fountain enters, you gain 2 life.
{T}: Add {C}.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Wall of Reverence

Defender, flying
At the beginning of your end step, you may gain life equal to the power of target creature you control.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is Esper Sentinel's power.

Creeping Bloodsucker

At the beginning of your upkeep, Creeping Bloodsucker deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Soul's Attendant

Whenever another creature enters, you may gain 1 life.

Spectrum Sentinel

Protection from multicolored (This creature can't be blocked, targeted, dealt damage, enchanted, or equipped by anything multicolored.)
Whenever a nonbasic land an opponent controls enters, you gain 1 life.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.