Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Great Unclean One

Reverberating Summons — At the beginning of your end step, each opponent loses 2 life. Then for each opponent who has less life than you, create a 1/3 black Demon creature token named Plaguebearer of Nurgle.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Raiders' Spoils

Creatures you control get +1/+0.
Whenever a Warrior you control deals combat damage to a player, you may pay 1 life. If you do, draw a card.

Solemn Simulacrum

When this creature enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When this creature dies, you may draw a card.

Sign in Blood

Target player draws two cards and loses 2 life.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Disciple of Griselbrand

{1}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arco-Flagellant

Squad {2} (As an additional cost to cast this spell, you may pay {2} any number of times. When this creature enters, create that many tokens that are copies of it.)
Arco-Flagellant can't block.
Endurant — Pay 3 life: Arco-Flagellant gains indestructible until end of turn.

Sol Ring

Infernal Sovereign

Flying, trample
Skip your draw step.
Whenever you play a land or cast a spell, you draw a card and you lose 1 life.

Myr Convert

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
{T}, Pay 2 life: Add one mana of any color.

Vault Skirge

({B/P} can be paid with either {B} or 2 life.)
Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Canoptek Wraith

Wraith Form — Canoptek Wraith can't be blocked.
Transdimensional Scout — When Canoptek Wraith deals combat damage to a player, you may pay {3} and sacrifice it. If you do, choose a land you control. Then search your library for up to two basic land cards which have the same name as the chosen land, put them onto the battlefield tapped, then shuffle.

Massacre Wurm

When this creature enters, creatures your opponents control get -2/-2 until end of turn.
Whenever a creature an opponent controls dies, that player loses 2 life.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Will-o'-the-Wisp

Flying (This creature can't be blocked except by creatures with flying or reach.)
{B}: Regenerate Will-o'-the-Wisp. (The next time this creature would be destroyed this turn, instead tap it, remove it from combat, and heal all damage on it.)

Erebos's Intervention

Choose one —
• Target creature gets -X/-X until end of turn. You gain X life.
• Exile up to twice X target cards from graveyards.

Mindblade Render

Whenever your opponents are dealt combat damage, if any of that damage was dealt by a Warrior, you draw a card and you lose 1 life.

Vraan, Executioner Thane

Whenever one or more other creatures you control die, each opponent loses 2 life and you gain 2 life. This ability triggers only once each turn.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Sorin the Mirthless

+1: Look at the top card of your library. You may reveal that card and put it into your hand. If you do, you lose life equal to its mana value.
−2: Create a 2/3 black Vampire creature token with flying and lifelink.
−7: Sorin the Mirthless deals 13 damage to any target. You gain 13 life.

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Gifted Aetherborn

Swamp

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap Staff of Compleation.

Loxodon Warhammer

Equipped creature gets +3/+0 and has trample and lifelink.
Equip {3}

Mischievous Poltergeist

Flying
Pay 1 life: Regenerate Mischievous Poltergeist.

Noxious Gearhulk

Menace
When Noxious Gearhulk enters, you may destroy another target creature. If a creature is destroyed this way, you gain life equal to its toughness.

Mortarion, Daemon Primarch

Flying
Primarch of the Death Guard — At the beginning of your end step, you may pay {X}. If you do, create X 2/2 black Astartes Warrior creature tokens with menace. X can't be greater than the amount of life you lost this turn.

Dark Ritual

Tallyman of Nurgle

Lifelink
The Seven-fold Chant — At the beginning of your end step, if a creature died this turn, you draw a card and you lose 1 life. If seven or more creatures died this turn, instead you draw seven cards and you lose 7 life.

Thrull Parasite

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
{T}, Pay 2 life: Remove a counter from target nonland permanent.

Sanguinary Priest

Lifelink
Blood Chalice — Whenever another creature you control dies, Sanguinary Priest deals 1 damage to any target.

Fell Stinger

Deathtouch
Exploit (When this creature enters, you may sacrifice a creature.)
When Fell Stinger exploits a creature, target player draws two cards and loses 2 life.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Infernal Idol

{T}: Add {B}.
{1}{B}{B}, {T}, Sacrifice Infernal Idol: You draw two cards and you lose 2 life.

Greed

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Dread Return

Return target creature card from your graveyard to the battlefield.
Flashback—Sacrifice three creatures. (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Infernal Grasp

Destroy target creature. You lose 2 life.

Swift End

Destroy target creature or planeswalker. You lose 2 life. (Then exile this card. You may cast the creature later from exile.)

Murderous Rider

Lifelink
When Murderous Rider dies, put it on the bottom of its owner's library.

Murderous Rider // Swift End

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Eternal Thirst

Enchant creature
Enchanted creature has lifelink and "Whenever a creature an opponent controls dies, put a +1/+1 counter on this creature." (Damage dealt by a creature with lifelink also causes its controller to gain that much life.)

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Ashnod's Altar

Tavern Swindler

{T}, Pay 3 life: Flip a coin. If you win the flip, you gain 6 life.

Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Decanter of Endless Water

You have no maximum hand size.
{T}: Add one mana of any color.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Thought Vessel

Primaris Eliminator

When Primaris Eliminator enters, choose one —
• Executioner Round — Destroy target creature.
• Hyperfrag Round — Creatures target player controls get -2/-2 until end of turn.