Agent of the Fates

Deathtouch
Heroic — Whenever you cast a spell that targets Agent of the Fates, each opponent sacrifices a creature of their choice.

Syndic of Tithes

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Basilica Screecher

Flying
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Favored Hoplite

Heroic — Whenever you cast a spell that targets Favored Hoplite, put a +1/+1 counter on Favored Hoplite and prevent all damage that would be dealt to it this turn.

Bitter Revelation

Look at the top four cards of your library. Put two of them into your hand and the rest into your graveyard. You lose 2 life.

Vizkopa Confessor

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
When Vizkopa Confessor enters, pay any amount of life. Target opponent reveals that many cards from their hand. You choose one of them and exile it.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Ultimate Price

Doom Blade

Orzhov Guildgate

This land enters tapped.
{T}: Add {W} or {B}.

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Tormented Hero

Tormented Hero enters tapped.
Heroic — Whenever you cast a spell that targets Tormented Hero, each opponent loses 1 life. You gain life equal to the life lost this way.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Swamp

Orzhov Charm

Choose one —
• Return target creature you control and all Auras you control attached to it to their owner's hand.
• Destroy target creature and you lose life equal to its toughness.
• Return target creature card with mana value 1 or less from your graveyard to the battlefield.

Hunted Witness

When Hunted Witness dies, create a 1/1 white Soldier creature token with lifelink.

Ulcerate

Target creature gets -3/-3 until end of turn. You lose 3 life.

Erase

Dutiful Thrull

Deathbringer Liege

Other white creatures you control get +1/+1.
Other black creatures you control get +1/+1.
Whenever you cast a white spell, you may tap target creature.
Whenever you cast a black spell, you may destroy target creature if it's tapped.

Treasury Thrull

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever Treasury Thrull attacks, you may return target artifact, creature, or enchantment card from your graveyard to your hand.

Gods Willing

Target creature you control gains protection from the color of your choice until end of turn. (It can't be blocked, targeted, dealt damage, enchanted, or equipped by anything of that color.)
Scry 1.

Plains

Sign in Blood

Target player draws two cards and loses 2 life.

Ordeal of Heliod

Enchant creature
Whenever enchanted creature attacks, put a +1/+1 counter on it. Then if it has three or more +1/+1 counters on it, sacrifice Ordeal of Heliod.
When you sacrifice Ordeal of Heliod, you gain 10 life.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Riot Control

You gain 1 life for each creature your opponents control. Prevent all damage that would be dealt to you this turn.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Castigate

Target opponent reveals their hand. You choose a nonland card from it and exile that card.

Blood Scrivener

If you would draw a card while you have no cards in hand, instead you draw two cards and you lose 1 life.