Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Treacherous Blessing

When this enchantment enters, draw three cards.
Whenever you cast a spell, you lose 1 life.
When this enchantment becomes the target of a spell or ability, sacrifice it.

Blackblade Reforged

Equipped creature gets +1/+1 for each land you control.
Equip legendary creature {3}
Equip {7}

Vorpal Sword

Equipped creature gets +2/+0 and has deathtouch.
{5}{B}{B}{B}: Until end of turn, this Equipment gains "Whenever equipped creature deals combat damage to a player, that player loses the game."
Equip {B}{B}

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Infernal Grasp

Destroy target creature. You lose 2 life.

Curtains' Call

Undaunted (This spell costs {1} less to cast for each opponent.)
Destroy two target creatures.

Cavalier of Night

Lifelink
When this creature enters, you may sacrifice another creature. When you do, destroy target creature an opponent controls.
When this creature dies, return target creature card with mana value 3 or less from your graveyard to the battlefield.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on this creature.

Brainstealer Dragon

Flying
At the beginning of your end step, exile the top card of each opponent's library. You may play those cards for as long as they remain exiled. If you cast a spell this way, you may spend mana as though it were mana of any color to cast it.
Whenever a nonland permanent an opponent owns enters the battlefield under your control, they lose life equal to its mana value.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Blood Artist

Whenever this creature or another creature dies, target player loses 1 life and you gain 1 life.

Phyrexian Etchings

Cumulative upkeep {B} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
At the beginning of your end step, draw a card for each age counter on this enchantment.
When this enchantment is put into a graveyard from the battlefield, you lose 2 life for each age counter on it.

Wall of Limbs

Defender (This creature can't attack.)
Whenever you gain life, put a +1/+1 counter on this creature.
{5}{B}{B}, Sacrifice this creature: Target player loses X life, where X is this creature's power.

Staff of Nin

At the beginning of your upkeep, draw a card.
{T}: This artifact deals 1 damage to any target.

Navigation Orb

{2}, {T}, Sacrifice this artifact: Search your library for up to two basic land cards and/or Gate cards, reveal those cards, put one onto the battlefield tapped and the other into your hand, then shuffle.

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When this creature dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Shriekmaw

Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
When this creature enters, destroy target nonartifact, nonblack creature.
Evoke {1}{B} (You may cast this spell for its evoke cost. If you do, it's sacrificed when it enters.)

Keening Stone

{5}, {T}: Target player mills X cards, where X is the number of cards in that player's graveyard.

Trespasser's Curse

Enchant player
Whenever a creature enchanted player controls enters, that player loses 1 life and you gain 1 life.

Invoke Despair

Target opponent sacrifices a creature of their choice. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Endless Atlas

{2}, {T}: Draw a card. Activate only if you control three or more lands with the same name.

Pendant of Prosperity

This artifact enters under the control of an opponent of your choice.
{2}, {T}: Draw a card, then you may put a land card from your hand onto the battlefield. This artifact's owner draws a card, then that player may put a land card from their hand onto the battlefield.

Sanctum of Stone Fangs

At the beginning of your first main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Creeping Bloodsucker

At the beginning of your upkeep, this creature deals 1 damage to each opponent. You gain life equal to the damage dealt this way.