Altar of the Pantheon

Your devotion to each color and each combination of colors is increased by one.
{T}: Add one mana of any color. If you control a God, a Demigod, or a legendary enchantment, you gain 1 life.

Daxos, Blessed by the Sun

Daxos's toughness is equal to your devotion to white. (Each {W} in the mana costs of permanents you control counts toward your devotion to white.)
Whenever another creature you control enters or dies, you gain 1 life.

Xander's Pact

Casualty 2 (As you cast this spell, you may sacrifice a creature with power 2 or greater. When you do, copy this spell.)
Each opponent exiles the top card of their library. You may cast spells from among those cards this turn. If you cast a spell this way, pay life equal to that spell's mana value rather than pay its mana cost.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Righteous Cause

Whenever a creature attacks, you gain 1 life.

Ruthless Knave

{2}{B}, Sacrifice a creature: Create two Treasure tokens. (They're artifacts with "{T}, Sacrifice this artifact: Add one mana of any color.")
Sacrifice three Treasures: Draw a card.

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform Chalice of Life.

Chalice of Life // Chalice of Death

Veinwitch Coven

Menace
Whenever you gain life, you may pay {B}. If you do, return target creature card from your graveyard to your hand.

Vampire Nighthawk

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Teysa, Envoy of Ghosts

Vigilance, protection from creatures
Whenever a creature deals combat damage to you, destroy that creature. Create a 1/1 white and black Spirit creature token with flying.

Lorcan, Warlock Collector

Flying
Whenever a creature card is put into an opponent's graveyard from anywhere, you may pay life equal to its mana value. If you do, put it onto the battlefield under your control. It's a Warlock in addition to its other types.
If a Warlock you control would die, exile it instead.

Profane Command

Choose two —
• Target player loses X life.
• Return target creature card with mana value X or less from your graveyard to the battlefield.
• Target creature gets -X/-X until end of turn.
• Up to X target creatures gain fear until end of turn. (They can't be blocked except by artifact creatures and/or black creatures.)

Evra, Halcyon Witness

Lifelink
{4}: Exchange your life total with Evra, Halcyon Witness's power.

Ajani's Mantra

At the beginning of your upkeep, you may gain 1 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Grim Haruspex

Morph {B} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)
Whenever another nontoken creature you control dies, draw a card.

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Marshland Bloodcaster

Flying
{1}{B}, {T}: Rather than pay the mana cost of the next spell you cast this turn, you may pay life equal to that spell's mana value.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Wayward Disciple

Whenever Wayward Disciple or another creature you control dies, target opponent loses 1 life and you gain 1 life.

Pious Evangel

Whenever Pious Evangel or another creature you control enters, you gain 1 life.
{2}, {T}, Sacrifice another permanent: Transform Pious Evangel.

Pious Evangel // Wayward Disciple

Barrowin of Clan Undurr

When Barrowin of Clan Undurr enters, venture into the dungeon. (Enter the first room or advance to the next room.)
Whenever Barrowin of Clan Undurr attacks, return up to one creature card with mana value 3 or less from your graveyard to the battlefield if you've completed a dungeon.

Evolving Wilds

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Loyal Sentry

When Loyal Sentry blocks a creature, destroy that creature and Loyal Sentry.

Basilica Screecher

Flying
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Ambition's Cost

You draw three cards and you lose 3 life.

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Celestine, the Living Saint

Flying, lifelink
Healing Tears — At the beginning of your end step, return target creature card with mana value X or less from your graveyard to the battlefield, where X is the amount of life you gained this turn.

Hierophant's Chalice

When Hierophant's Chalice enters, target opponent loses 1 life and you gain 1 life.
{T}: Add {C}.

Sunlit Marsh

({T}: Add {W} or {B}.)
Sunlit Marsh enters tapped.

Leeching Lurker

Lifelink
Nightbound (If a player casts at least two spells during their own turn, it becomes day next turn.)

Curse of Leeches

Enchant player
As this permanent transforms into Curse of Leeches, attach it to a player.
At the beginning of enchanted player's upkeep, they lose 1 life and you gain 1 life.
Daybound (If a player casts no spells during their own turn, it becomes night next turn.)

Curse of Leeches // Leeching Lurker

Edgar Markov's Coffin

At the beginning of your upkeep, create a 1/1 white and black Vampire creature token with lifelink and put a bloodline counter on Edgar Markov's Coffin. Then if there are three or more bloodline counters on it, remove those counters and transform it.

Edgar, Charmed Groom

Other Vampires you control get +1/+1.
When Edgar, Charmed Groom dies, return it to the battlefield transformed under its owner's control.

Edgar, Charmed Groom // Edgar Markov's Coffin

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Sunscorch Regent and you gain 1 life.

Campaign of Vengeance

Whenever a creature you control attacks, defending player loses 1 life and you gain 1 life.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Mask of Griselbrand

Equipped creature has flying and lifelink.
Whenever equipped creature dies, you may pay X life, where X is its power. If you do, draw X cards.
Equip {3}

Elenda and Azor

Flying, ward {2}
Whenever Elenda and Azor attacks, you may pay {X}{W}{U}{B}. If you do, draw X cards.
At the beginning of each end step, you may pay 4 life. If you do, create a number of 1/1 black Vampire Knight creature tokens with lifelink equal to the number of cards you've drawn this turn.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Swamp

Resolute Archangel

Flying
When Resolute Archangel enters, if your life total is less than your starting life total, it becomes equal to your starting life total.

Tenured Inkcaster

When Tenured Inkcaster enters, put a +1/+1 counter on target creature.
Whenever a creature you control with a +1/+1 counter on it attacks, each opponent loses 1 life and you gain 1 life.

Infernal Grasp

Destroy target creature. You lose 2 life.

Zhentarim Bandit

Whenever Zhentarim Bandit attacks, you may pay 1 life. If you do, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Scholar of Athreos

{2}{B}: Each opponent loses 1 life. You gain life equal to the life lost this way.

Grasping Thrull

Flying
When Grasping Thrull enters, it deals 2 damage to each opponent and you gain 2 life.

Thieving Amalgam

At the beginning of each opponent's upkeep, you manifest the top card of that player's library. (Put it onto the battlefield face down as a 2/2 creature. Turn it face up any time for its mana cost if it's a creature card.)
Whenever a creature you control but don't own dies, its owner loses 2 life and you gain 2 life.

Syndic of Tithes

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Kami of the Honored Dead

Flying
Whenever Kami of the Honored Dead is dealt damage, you gain that much life.
Soulshift 6 (When this creature dies, you may return target Spirit card with mana value 6 or less from your graveyard to your hand.)

Palace Siege

As Palace Siege enters, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Markov Purifier

Lifelink
At the beginning of your end step, if you gained life this turn, you may pay {2}. If you do, draw a card.

Bloodtracker

Flying
{B}, Pay 2 life: Put a +1/+1 counter on Bloodtracker.
When Bloodtracker leaves the battlefield, draw a card for each +1/+1 counter on it.

Quietus Spike

Equipped creature has deathtouch.
Whenever equipped creature deals combat damage to a player, that player loses half their life, rounded up.
Equip {3}

Paladin of Prahv

Whenever Paladin of Prahv deals damage, you gain that much life.
Forecast — {1}{W}, Reveal Paladin of Prahv from your hand: Whenever target creature deals damage this turn, you gain that much life. (Activate only during your upkeep and only once each turn.)

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Sanctum Seeker

Whenever a Vampire you control attacks, each opponent loses 1 life and you gain 1 life.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Lampad of Death's Vigil

{1}, Sacrifice a creature: Each opponent loses 1 life and you gain 1 life.

Daxos the Returned

Whenever you cast an enchantment spell, you get an experience counter.
{1}{W}{B}: Create a white and black Spirit enchantment creature token. It has "This creature's power and toughness are each equal to the number of experience counters you have."

Night Market Lookout

Whenever Night Market Lookout becomes tapped, each opponent loses 1 life and you gain 1 life.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Plague of Vermin

Starting with you, each player may pay any amount of life. Repeat this process until no one pays life. Each player creates a 1/1 black Rat creature token for each 1 life they paid this way.

Dutiful Thrull

Consuming Vapors

Target player sacrifices a creature of their choice. You gain life equal to that creature's toughness.
Rebound (If you cast this spell from your hand, exile it as it resolves. At the beginning of your next upkeep, you may cast this card from exile without paying its mana cost.)

Bontu the Glorified

Menace, indestructible
Bontu the Glorified can't attack or block unless a creature died under your control this turn.
{1}{B}, Sacrifice another creature: Scry 1. Each opponent loses 1 life and you gain 1 life.

Callous Bloodmage

When Callous Bloodmage enters, choose one —
• Create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."
• You draw a card and you lose 1 life.
• Exile target player's graveyard.

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Firja, Judge of Valor

Flying, lifelink
Whenever you cast your second spell each turn, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.

Ash Barrens

{T}: Add {C}.
Basic landcycling {1} ({1}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Fleshtaker

Whenever you sacrifice another creature, you gain 1 life and scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{1}, Sacrifice another creature: Fleshtaker gets +2/+2 until end of turn.

Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Fell the Mighty

Destroy all creatures with power greater than target creature's power.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Tymna the Weaver

Lifelink
At the beginning of each of your postcombat main phases, you may pay X life, where X is the number of opponents that were dealt combat damage this turn. If you do, draw X cards.
Partner (You can have two commanders if both have partner.)

Ancestor's Chosen

First strike (This creature deals combat damage before creatures without first strike.)
When Ancestor's Chosen enters, you gain 1 life for each card in your graveyard.

Orzhov Guildgate

This land enters tapped.
{T}: Add {W} or {B}.

Reveillark

Flying
When Reveillark leaves the battlefield, return up to two target creature cards with power 2 or less from your graveyard to the battlefield.
Evoke {5}{W} (You may cast this spell for its evoke cost. If you do, it's sacrificed when it enters.)

Greven, Predator Captain

Menace
Greven, Predator Captain gets +X/+0, where X is the amount of life you've lost this turn.
Whenever Greven attacks, you may sacrifice another creature. If you do, you draw cards equal to that creature's power and you lose life equal to that creature's toughness.

Lone Missionary

When Lone Missionary enters, you gain 4 life.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Blind Hunter

Flying
Haunt (When this creature dies, exile it haunting target creature.)
When Blind Hunter enters or the creature it haunts dies, target player loses 2 life and you gain 2 life.

Vault of the Archangel

{T}: Add {C}.
{2}{W}{B}, {T}: Creatures you control gain deathtouch and lifelink until end of turn.

Shadows of the Past

Whenever a creature dies, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{4}{B}: Each opponent loses 2 life and you gain 2 life. Activate only if there are four or more creature cards in your graveyard.

Breena, the Demagogue

Flying
Whenever a player attacks one of your opponents, if that opponent has more life than another of your opponents, that attacking player draws a card and you put two +1/+1 counters on a creature you control.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Phyrexian Purge

This spell costs 3 life more to cast for each target.
Destroy any number of target creatures.

Death Cultist

Sacrifice Death Cultist: Target player loses 1 life and you gain 1 life.

Corpse Knight

Whenever another creature you control enters, each opponent loses 1 life.

Soul Bleed

Enchant creature
At the beginning of the upkeep of enchanted creature's controller, that player loses 1 life.